Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MTA1 [nucleoplasm]
Stable Identifier
R-HSA-3465550
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Metastasis-associated protein MTA1, MTA1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q13422 IKZF1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)
MTA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13330 MTA1
Gene Names
MTA1
Chain
chain:1-715
Reference Genes
BioGPS Gene:9112 MTA1
COSMIC (genes):MTA1 MTA1
CTD Gene:9112 MTA1
dbSNP Gene:9112 MTA1
ENSEMBL:ENSG00000182979 MTA1
ENSEMBL_homo_sapiens_GENE:ENSG00000182979.18 MTA1
HGNC:7410 MTA1
KEGG Gene (Homo sapiens):9112 MTA1
Monarch:9112 MTA1
NCBI Gene:9112 MTA1
OMIM:603526 MTA1
UCSC:Q13330 MTA1
Reference Transcript
RefSeq:NM_001203258.1 MTA1
RefSeq:NM_004689.3 MTA1
Other Identifiers
11727668_a_at
11746358_a_at
11757774_x_at
1642_at
1643_g_at
16789681
202247_PM_s_at
202247_s_at
211783_PM_s_at
211783_s_at
3554748
3554749
3554760
3554767
3554776
3554778
3554780
3554781
3554785
3554787
3554788
3554790
3554792
3554794
3554795
3554796
3554797
3554799
3554800
3554802
3554805
3554806
3554810
3554812
3554813
3554815
3554816
3554817
38633_at
7977373
9112
A_14_P123899
A_23_P9513
A_24_P241370
A_33_P3359306
GE59104
GO:0000122
GO:0000978
GO:0003677
GO:0003682
GO:0003713
GO:0003714
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0006281
GO:0006302
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0007165
GO:0010212
GO:0016581
GO:0023052
GO:0030154
GO:0030163
GO:0032922
GO:0036211
GO:0042659
GO:0042826
GO:0043153
GO:0043161
GO:0043226
GO:0043231
GO:0043565
GO:0045475
GO:0045814
GO:0045892
GO:0045893
GO:0046872
GO:0048511
GO:0061629
GO:0140110
GO:1902499
GO:2000736
HMNXSV003027770
Hs.101448.0.S1_3p_s_at
ILMN_1671911
PH_hs_0005642
TC14000836.hg
U35113_at
g13544097_3p_s_at
Participates
as an input of
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)
as a member of
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
polySUMO2,3-K509-MTA1 [nucleoplasm]
Inferred To
MTA1-like [nucleoplasm]
(Drosophila melanogaster)
lin-40 [nucleoplasm]
(Caenorhabditis elegans)
MTA1 [nucleoplasm]
(Bos taurus)
MTA1 [nucleoplasm]
(Canis familiaris)
MTA1 [nucleoplasm]
(Gallus gallus)
MTA1 [nucleoplasm]
(Sus scrofa)
mybS [nucleoplasm]
(Dictyostelium discoideum)
Mta1 [nucleoplasm]
(Mus musculus)
Mta1 [nucleoplasm]
(Rattus norvegicus)
mta1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004680.2
,
NP_001190187.1
OpenTargets
ENSG00000182979
GeneCards
Q13330
HPA
ENSG00000182979-MTA1
Ensembl
ENSP00000384180
,
ENSP00000393438
,
ENST00000438610
,
ENST00000331320
,
ENST00000405646
,
ENSP00000333633
,
ENSG00000182979
PRO
Q13330
Pharos - Targets
Q13330
PDB
4BKX
,
7AO8
,
6G16
,
5FXY
,
7AO9
,
7AOA
,
4PC0
,
5ICN
,
6ZRD
,
6ZRC
,
4PBY
,
4PBZ
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.929
16
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.904
14
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.886
7
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.725
6
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.666
4
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.666
4
UniProt:Q13422 IKZF1
0.666
5
UniProt:O14519 CDKA1
0.643
4
UniProt:O60315 ZEB2
1
ZEB2 [nucleoplasm]
(R-HSA-3108222)
0.612
12
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.597
3
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.59
4
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.577
9
UniProt:P43364-2 MAGEA11
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.556
6
UniProt:Q6FGM0 Q6FGM0
0.556
3
UniProt:Q58EX7 PLEKHG4
1
PLEKHG4 [cytosol]
(R-HSA-9679579)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
1
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
0.556
3
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.556
3
UniProt:O00505 KPNA3
2
KPNA3 [nucleoplasm]
(R-HSA-1176061)
KPNA3 [cytosol]
(R-HSA-1176070)
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P19784 CSNK2A2
2
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
CSNK2A2 [cytosol]
(R-HSA-201721)
0.527
2
UniProt:Q86YP4 GATAD2A
1
GATAD2A [nucleoplasm]
(R-HSA-3702077)
0.527
3
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.527
4
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.527
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.527
4
UniProt:Q9NSY1 BMP2K
0.488
2
UniProt:Q9BRD0 BUD13
1
BUD13 [nucleoplasm]
(R-HSA-9769522)
0.483
2
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.483
2
UniProt:A2A935 Prdm16
2
Prdm16 [nucleoplasm]
(R-MMU-9854760)
Prdm16 [cytosol]
(R-MMU-5634812)
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text