Autodegradation of the E3 ubiquitin ligase COP1

Stable Identifier
R-HSA-349425
Type
Pathway
Species
Homo sapiens
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COP1 is one of several E3 ubiquitin ligases responsible for the tight regulation of p53 abundance. Following DNA damage, COP1 dissociates from p53 and is inactivated by autodegradation via a pathway involving ATM phosphorylation of COP1 on Ser(387), autoubiquitination and proteasome mediated degradation. Destruction of COP1 results in abrogation of the ubiquitination and degradation of p53 (Dornan et al., 2006).

Literature References
PubMed ID Title Journal Year
16931761 ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage

Dornan, D, Shimizu, H, Mah, A, Dudhela, T, Eby, M, O'Rourke, K, Seshagiri, S, Dixit, VM

Science 2006
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Orthologous Events
Cross References
BioModels Database
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Created