Phosphorylation of MDM4 by CHEK2

Stable Identifier
R-HSA-349426
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 at serine residues S342 and S367 in vivo. CHEK2-mediated phosphorylation stimulates MDM4 ubiquitination by MDM2 and subsequent degradation (Chen et al. 2005).

Literature References
PubMed ID Title Journal Year
16163388 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

Chen, L, Gilkes, DM, Pan, Y, Lane, WS, Chen, J

EMBO J 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed