Reactome: A Curated Pathway Database

Phosphorylation of MDM4 by CHEK2

Stable Identifier
R-HSA-349426
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 at serine residues S342 and S367 in vivo. CHEK2-mediated phosphorylation stimulates MDM4 ubiquitination by MDM2 and subsequent degradation (Chen et al. 2005).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm] p-S,3T-CHEK2 [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events