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p-S346,S367,S403-MDM4 [nucleoplasm]
Stable Identifier
R-HSA-349441
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
MDM2 ubiquitinates phosphorylated MDM4 (Homo sapiens)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
Phosphorylation of MDM4 by CHEK2 (Homo sapiens)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
MDM2 ubiquitinates phosphorylated MDM4 (Homo sapiens)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
Phosphorylation of MDM4 by CHEK2 (Homo sapiens)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
USP7 deubiquitinates MDM2 (Homo sapiens)
p-S166,S188-MDM2:(p-S166,S188-MDM2,p-S346,S367,S403-MDM4) [nucleoplasm] (Homo sapiens)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP2 deubiquitinates MDM2,MDM4 (Homo sapiens)
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
16163388
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
Lane, WS
,
Chen, L
,
Pan, Y
,
Chen, J
,
Gilkes, DM
EMBO J
2005
External Reference Information
External Reference
UniProt:O15151 MDM4
Gene Names
MDM4, MDMX
Chain
chain:1-490
Reference Genes
BioGPS Gene:4194 MDM4
COSMIC (genes):MDM4 MDM4
CTD Gene:4194 MDM4
dbSNP Gene:4194 MDM4
ENSEMBL:ENSG00000198625 MDM4
ENSEMBL_homo_sapiens_GENE:ENSG00000198625.14 MDM4
HGNC:6974 MDM4
KEGG Gene (Homo sapiens):4194 MDM4
Monarch:4194 MDM4
NCBI Gene:4194 MDM4
OMIM:602704 MDM4
UCSC:O15151 MDM4
Reference Transcript
RefSeq:NM_001204171.1 MDM4
RefSeq:NM_001278516.1 MDM4
RefSeq:NM_002393.4 MDM4
RefSeq:NM_001278519.1 MDM4
RefSeq:NM_001278518.1 MDM4
RefSeq:NM_001204172.1 MDM4
RefSeq:NM_001278517.1 MDM4
Other Identifiers
11721912_at
11721913_x_at
11721914_a_at
11721915_a_at
11721916_at
16676314
1935_at
205655_PM_at
205655_at
225740_PM_x_at
225740_x_at
225742_PM_at
225742_at
235162_PM_at
235162_at
236814_PM_at
236814_at
2376038
2376039
2376040
2376041
2376042
2376044
2376045
2376046
2376054
2376055
2376061
2376062
2376063
2376064
2376065
2376066
2376067
2376068
2376069
2376070
2376071
2376072
2376073
2376074
2376094
2376095
2376096
2376097
4194
44569_at
7909011
83495_at
90290_at
91831_s_at
AF007111_at
A_14_P108985
A_14_P124092
A_19_P00320719
A_19_P00320721
A_19_P00329800
A_23_P103503
A_24_P778649
A_33_P3389376
GE81150
GE88836
GO:0000122
GO:0003170
GO:0003181
GO:0003203
GO:0003281
GO:0003283
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0006351
GO:0006355
GO:0008270
GO:0008285
GO:0012501
GO:0016567
GO:0016740
GO:0017053
GO:0019899
GO:0023052
GO:0030163
GO:0030330
GO:0036211
GO:0042177
GO:0043066
GO:0043226
GO:0045892
GO:0046872
GO:0048856
GO:0050821
GO:0051726
GO:0065003
GO:0065008
GO:0071456
GO:0140096
HMNXSV003003592
HMNXSV003055900
Hs.126257.0.A1_3p_at
Hs.154395.0.A1_3p_at
Hs.31433.0.A1_3p_at
Hs.31433.0.A2_3p_at
ILMN_1746020
PH_hs_0025232
TC01004964.hg
g4505138_3p_at
Participates
as a component of
p-S166,S188-MDM2:p-S346,S367,S403-MDM4 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PolyUb-MDM4 [nucleoplasm]
p-S403-MDM4 [nucleoplasm]
PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
MDM4 [nucleoplasm]
Inferred To
phospho-mdm4 [nucleoplasm]
(Danio rerio)
phospho-MDM4 [nucleoplasm]
(Canis familiaris)
phospho-Mdm4 [nucleoplasm]
(Mus musculus)
phospho-Mdm4 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 342
Coordinate
342
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 367
Coordinate
367
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 403
Coordinate
403
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001265448.1
,
NP_001191101.1
,
NP_002384.2
,
NP_001265447.1
,
NP_001265446.1
,
NP_001191100.1
,
NP_001265445.1
OpenTargets
ENSG00000198625
GeneCards
O15151
HPA
ENSG00000198625-MDM4
ZINC - Substances
MDM4_HUMAN
ZINC target
O15151
Ensembl
ENSP00000356150
,
ENSG00000198625
,
ENSP00000396840
,
ENST00000454264
,
ENST00000367183
,
ENSP00000356151
,
ENST00000367182
PRO
O15151
Pharos - Targets
O15151
ZINC - Predictions - Purchasable
MDM4_HUMAN
Orphanet
25627
PDB
6Q9W
,
6YR7
,
2VYR
,
2N06
,
7MLA
,
6Q9Y
,
3LBJ
,
2VJE
,
3FDO
,
6Q9S
,
3JZO
,
8HDG
,
7C44
,
6YR5
,
7C3Y
,
6Q9U
,
2CR8
,
5MNJ
,
2VJF
,
3JZQ
,
7C3Q
,
3FE7
,
7EL4
,
3DAB
,
3JZP
,
6Q9Q
,
2MWY
,
5UML
,
3MQR
,
2N14
,
7KJN
,
8IA5
,
2N0W
,
3FEA
,
5VK1
,
3U15
,
4RXZ
,
2N0U
,
3EQY
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.966
22
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.938
15
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.758
5
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.758
5
UniProt:O95971 CD160
1
CD160 [plasma membrane]
(R-HSA-198014)
0.718
6
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.711
15
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.611
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.589
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.556
3
UniProt:P68871 HBB
8
CO-H+-HBB [cytosol]
(R-HSA-1237013)
HBB [ficolin-1-rich granule lumen]
(R-HSA-6801015)
HBB [tertiary granule lumen]
(R-HSA-6800191)
HBB [endocytic vesicle lumen]
(R-HSA-2230936)
HBB [extracellular region]
(R-HSA-2168872)
HBB [late endosome lumen]
(R-HSA-9631108)
HBB [cytosol]
(R-HSA-1008196)
HBB [lysosomal lumen]
(R-HSA-9625193)
0.527
3
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.527
2
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.524
4
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.499
4
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