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p-S387-RFWD2 [nucleoplasm]
Stable Identifier
R-HSA-349450
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phospho-COP1(Ser 387)
Locations in the PathwayBrowser for interactor UniProt:Q16531 DDB1
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
Dissociation of the COP1-p53 complex (Homo sapiens)
p-S387-RFWD2 [nucleoplasm] (Homo sapiens)
Phosphorylation of COP1 at Ser-387 by ATM (Homo sapiens)
p-S387-RFWD2 [nucleoplasm] (Homo sapiens)
Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)
p-S387-RFWD2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NHY2 RFWD2
Gene Names
RFWD2, COP1, RNF200
Chain
chain:1-731
Reference Genes
BioGPS Gene:64326 RFWD2
CTD Gene:64326 RFWD2
dbSNP Gene:64326 RFWD2
ENSEMBL:ENSG00000143207 RFWD2
ENSEMBL_homo_sapiens_GENE:ENSG00000143207.21 RFWD2
HGNC:17440 RFWD2
KEGG Gene (Homo sapiens):64326 RFWD2
Monarch:64326 RFWD2
NCBI Gene:64326 RFWD2
OMIM:608067 RFWD2
UCSC:Q8NHY2 RFWD2
Reference Transcript
RefSeq:NM_001001740.3 RFWD2
RefSeq:NM_022457.6 RFWD2
RefSeq:NM_001286644.1 RFWD2
Other Identifiers
11718171_a_at
11758554_s_at
1552617_PM_a_at
1552617_a_at
16696657
234950_PM_s_at
234950_s_at
2445149
2445150
2445151
2445167
2445169
2445171
2445177
2445178
2445181
2445182
2445183
2445194
2445195
2445205
2445210
2445211
2445212
2445215
2445222
2445224
2445226
2445227
2445230
2445233
2445234
2445242
3777798
48053_at
64326
71520_i_at
71521_r_at
7922504
A_23_P92292
A_33_P3209356
GE55736
GE687043
GE82692
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0010212
GO:0016567
GO:0016607
GO:0016740
GO:0030163
GO:0031464
GO:0032436
GO:0036211
GO:0043161
GO:0043226
GO:0043229
GO:0046872
GO:0061630
GO:0140096
HMNXSV003009284
HMNXSV003045421
Hs.105737.1.S1_3p_a_at
Hs2.105737.1.S1_3p_s_at
ILMN_1661002
ILMN_2294644
ILMN_2408001
PH_hs_0024921
TC01003551.hg
Participates
as an input of
Translocation of COP1 from the nucleus to the cytoplasm (Homo sapiens)
as an output of
Phosphorylation of COP1 at Ser-387 by ATM (Homo sapiens)
Dissociation of the COP1-p53 complex (Homo sapiens)
as a component of
p-S387-RFWD2:p-S15-TP53 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RFWD2 [nucleoplasm]
p-S387-RFWD2 [cytosol]
Inferred To
phospho-COP1 [nucleoplasm]
(Bos taurus)
phospho-COP1 [nucleoplasm]
(Canis familiaris)
phospho-COP1 [nucleoplasm]
(Sus scrofa)
phospho-cop1 [nucleoplasm]
(Danio rerio)
phospho-cop1 [nucleoplasm]
(Xenopus tropicalis)
phospho-Cop1 [nucleoplasm]
(Mus musculus)
phospho-Cop1 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S387-RFWD2 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-S387-RFWD2 [nucleoplasm]
(Gallus gallus)
phospho-par-2 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 387
Coordinate
387
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_071902.2
,
NP_001273573.1
,
NP_001001740.1
GeneCards
Q8NHY2
HPA
ENSG00000143207-COP1
Ensembl
ENST00000308769
,
ENSG00000143207
,
ENSP00000310943
,
ENST00000367669
,
ENSP00000433517
,
ENST00000474194
,
ENSP00000356641
PRO
Q8NHY2
Pharos - Targets
Q8NHY2
PDB
5IGQ
,
5HQG
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.725
6
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.718
6
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.717
5
UniProt:P05412 JUN
4
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
0.708
5
UniProt:Q92519 TRIB2
0.623
4
UniProt:P41161 ETV5
0.604
4
UniProt:P15036 ETS2
2
p-T72-ETS2 [nucleoplasm]
(R-HSA-3132735)
ETS2 [nucleoplasm]
(R-HSA-1629811)
0.564
2
UniProt:P50549 ETV1
0.564
4
UniProt:Q96RU7 TRIB3
3
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.527
2
UniProt:Q96RU8 TRIB1
1
TRIB1 [cytosol]
(R-HSA-9621338)
0.527
3
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.527
2
UniProt:Q8N2I9 STK40
0.527
4
UniProt:P18850 ATF6
7
ATF6 [endoplasmic reticulum membrane]
(R-HSA-381222)
ATF6 [Golgi membrane]
(R-HSA-381000)
ATF6(1-419) [Golgi membrane]
(R-HSA-420815)
ATF6(1-380) [cytosol]
(R-HSA-381075)
ATF6(380-419) [Golgi membrane]
(R-HSA-420817)
ATF6(420-670) [Golgi membrane]
(R-HSA-420814)
ATF6(1-380) [nucleoplasm]
(R-HSA-381211)
0.527
2
UniProt:P15408 FOSL2
0.527
3
UniProt:Q7L5N1 COPS6
2
COPS6 [nucleoplasm]
(R-HSA-5697026)
COPS6 [cytosol]
(R-HSA-416961)
0.525
3
UniProt:P14921-1 ETS1
0.524
3
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