Reactome | RFWD2 [nucleoplasm]

RFWD2 [nucleoplasm]

Stable Identifier

R-HSA-349454

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

COP1

Locations in the PathwayBrowser for interactor UniProt:Q7L5N1 COPS6

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
        
        Phosphorylation of COP1 at Ser-387 by ATM (Homo sapiens)
        
        RFWD2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NHY2 COP1

Gene Names

RFWD2, COP1, RNF200

Chain

chain:1-731

Reference Genes

BioGPS Gene:64326 RFWD2

CTD Gene:64326 RFWD2

dbSNP Gene:64326 RFWD2

ENSEMBL:ENSG00000143207 RFWD2

HGNC:17440 RFWD2

KEGG Gene (Homo sapiens):64326 RFWD2

Monarch:64326 RFWD2

NCBI Gene:64326 RFWD2

OMIM:608067 RFWD2

UCSC:Q8NHY2 RFWD2

Reference Transcript

Other Identifiers

11718171_a_at

11758554_s_at

1552617_a_at

16696657

234950_s_at

2445149

2445150

2445151

2445167

2445169

2445171

2445177

2445178

2445181

2445182

2445183

2445194

2445195

2445205

2445210

2445211

2445212

2445215

2445222

2445224

2445226

2445227

2445230

2445233

2445234

2445242

3777798

48053_at

64326

71520_i_at

71521_r_at

7922504

A_23_P92292

A_33_P3209356

GE55736

GE82692

GO:0000139

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006464

GO:0008150

GO:0009056

GO:0010212

GO:0016567

GO:0016607

GO:0016740

GO:0031464

GO:0032436

GO:0032991

GO:0043161

GO:0043167

GO:0043226

GO:0043687

GO:0046872

GO:0061630

Hs.105737.1.S1_3p_a_at

Hs2.105737.1.S1_3p_s_at

ILMN_1661002

ILMN_2294644

ILMN_2408001

PH_hs_0024921

TC01003551.hg

Participant Of

hasMember

DCAF protein [nucleoplasm]

input

Phosphorylation of COP1 at Ser-387 by ATM

Other forms of this molecule

p-S387-RFWD2 [cytosol]

p-S387-RFWD2 [nucleoplasm]

Inferred To

par-2 [nucleoplasm] (Caenorhabditis elegans)

COP1 [nucleoplasm] (Canis familiaris)

COP1 [nucleoplasm] (Sus scrofa)

RFWD2 [nucleoplasm] (Dictyostelium discoideum)

RFWD2 [nucleoplasm] (Gallus gallus)

cop1 [nucleoplasm] (Danio rerio)

cop1 [nucleoplasm] (Xenopus tropicalis)

Cop1 [nucleoplasm] (Mus musculus)

Cop1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001001740.1, NP_001273573.1, NP_071902.2

IntEnz

2.3.2.27

HPA

ENSG00000143207-COP1

GeneCards

Q8NHY2

Ensembl

ENSP00000356641, ENSP00000310943, ENST00000474194, ENSP00000433517, ENST00000308769, ENST00000367669, ENSG00000143207

PRO

Q8NHY2

PDB

5IGQ, 5HQG

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.718	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.717	5
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.623	4
UniProt:P15036 ETS2	2	ETS2 [nucleoplasm] (R-HSA-1629811) p-T72-ETS2 [nucleoplasm] (R-HSA-3132735)	0.564	2
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.527	4
UniProt:P01100 FOS	2	p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283) FOS [nucleoplasm] (R-HSA-450216)	0.527	3
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.525	3
UniProt:P14921-1 ETS1			0.524	3

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