Phosphorylation of MDM4 by ATM

Stable Identifier
R-HSA-349455
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Human MDM4 (MDMX) is phosphorylated on serine residue S403 by ATM. This site is important for MDM2-mediated ubiquitination of MDM4 after induction of double strand DNA breaks (Pereg et al. 2005, Chen et al. 2005).

Literature References
PubMed ID Title Journal Year
15788536 Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

Pereg, Y, Shkedy, D, de Graaf, P, Meulmeester, E, Edelson-Averbukh, M, Salek, M, Biton, S, Teunisse, AF, Lehmann, WD, Jochemsen, AG, Shiloh, Y

Proc Natl Acad Sci U S A 2005
16163388 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

Chen, L, Gilkes, DM, Pan, Y, Lane, WS, Chen, J

EMBO J 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created