Reactome: A Curated Pathway Database

Phosphorylation of MDM4 by ATM

Stable Identifier
R-HSA-349455
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Human MDM4 (MDMX) is phosphorylated on serine residue S403 by ATM. This site is important for MDM2-mediated ubiquitination of MDM4 after induction of double strand DNA breaks (Pereg et al. 2005, Chen et al. 2005).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm] p-S1981,Ac-K3016-ATM [nucleoplasm] protein serine/threonine kinase activity (0004674)
Orthologous Events