Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1)

Stable Identifier
R-HSA-349603
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1)
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Thrombospondin-1 (TSP-1) secreted from platelet alpha granules on thrombin activation associates with actin cytoskeleton. This association of TSP-1 with actin cytoskeleton is mediated by the membrane receptor alphaIIbbeta3.
Literature References
PubMed ID Title Journal Year
2010551 Thrombospondin-induced adhesion of human platelets

Tuszynski, GP, Kowalska, MA

J Clin Invest 1991
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Authored
Geiger, B  (2008-05-07)
Horwitz, AR  (2008-05-07)
Reviewed
Humphries, MJ  (2008-05-07)
Yamada, KM  (2008-05-07)
Hynes, R  (2008-05-07)
Created
Garapati, P V  (2008-05-12)
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