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spherical HDL and SR-BI receptor form a complex at the cell surface
Stable Identifier
R-HSA-349637
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
HDL clearance (Homo sapiens)
spherical HDL and SR-BI receptor form a complex at the cell surface (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
An extracellular spherical HDL particle binds to the plasma membrance-associated SR-BI receptor with high affinity (Murao et al. 1997). In the body SR-BI receptors are abundant on the surfaces of steroidogenic cells in the adrenal glands and gonads, and on hepatocytes. SR-BI thus appears to play a central role in cholesterol uptake for steroid hormone synthesis and for bile acid synthesis and cholesterol excretion (Rigotti et al. 2003; Silver and Tall 2001).
Literature References
PubMed ID
Title
Journal
Year
9211901
Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes
Terpstra, V
,
Green, SR
,
Murao, K
,
Kondratenko, N
,
Steinberg, D
,
Quehenberger, O
J Biol Chem
1997
Participants
Input
SCARB1-2 [plasma membrane]
(Homo sapiens)
spherical HDL [extracellular region]
(Homo sapiens)
Output
spherical HDL:SR-BI complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
HDL clearance (Homo sapiens)
Orthologous Events
spherical HDL and SR-BI receptor form a complex at the cell surface (Bos taurus)
spherical HDL and SR-BI receptor form a complex at the cell surface (Canis familiaris)
spherical HDL and SR-BI receptor form a complex at the cell surface (Gallus gallus)
spherical HDL and SR-BI receptor form a complex at the cell surface (Mus musculus)
spherical HDL and SR-BI receptor form a complex at the cell surface (Rattus norvegicus)
spherical HDL and SR-BI receptor form a complex at the cell surface (Sus scrofa)
Authored
D'Eustachio, P (2008-05-12)
Reviewed
Jassal, B (2008-06-13)
Created
D'Eustachio, P (2008-05-12)
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