Reactome | ACTN2 [extracellular region]

ACTN2 [extracellular region]

Stable Identifier

R-HSA-349725

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Alpha-actinin 2

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [extracellular region] (Homo sapiens)
        
        Alpha actinins [extracellular region] (Homo sapiens)
        
        ACTN2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35609 ACTN2

Gene Names

ACTN2

Chain

chain:1-894

Reference Genes

BioGPS Gene:88 ACTN2

COSMIC (genes):ACTN2 ACTN2

CTD Gene:88 ACTN2

dbSNP Gene:88 ACTN2

ENSEMBL:ENSG00000077522 ACTN2

HGNC:164 ACTN2

KEGG Gene (Homo sapiens):88 ACTN2

Monarch:88 ACTN2

NCBI Gene:88 ACTN2

OMIM:102573 ACTN2

UCSC:P35609 ACTN2

Reference Transcript

Other Identifiers

0004760059

11734001_at

11734002_a_at

11734003_at

11749692_a_at

11751575_a_at

11758470_s_at

16679064

203861_s_at

203862_s_at

203863_at

203864_s_at

2386944

2386945

2386955

2386956

2386957

2386960

2386963

2386965

2386967

2386972

2386973

2386977

2386979

2386982

2386984

2386985

2386987

2386989

2386991

2386992

2386993

2386994

2386996

2386999

2387000

2387001

2387002

2387003

2387004

2387005

38448_at

61882_at

7910727

A_23_P115021

A_33_P3212167

GE61094

GO:0000165

GO:0002576

GO:0003674

GO:0003779

GO:0005178

GO:0005198

GO:0005509

GO:0005515

GO:0005546

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0006464

GO:0006810

GO:0006936

GO:0007010

GO:0007155

GO:0007165

GO:0008092

GO:0008150

GO:0008219

GO:0008289

GO:0008307

GO:0009058

GO:0016192

GO:0019904

GO:0022607

GO:0030017

GO:0030018

GO:0030035

GO:0030049

GO:0030154

GO:0030175

GO:0030274

GO:0030374

GO:0030864

GO:0031093

GO:0031143

GO:0031410

GO:0031432

GO:0034330

GO:0034641

GO:0042391

GO:0042802

GO:0042981

GO:0043167

GO:0043197

GO:0043226

GO:0043267

GO:0043268

GO:0044325

GO:0045214

GO:0045893

GO:0046872

GO:0048041

GO:0048646

GO:0048856

GO:0051015

GO:0051373

GO:0051695

GO:0055013

GO:0055085

GO:0070062

GO:0070080

GO:0072659

GO:0086097

GO:0098839

GO:0098978

GO:0099092

GO:1901017

GO:1901018

GO:2000009

GO:2000310

GO:2001137

GO:2001259

HMNXSV003055491

Hs.83672.0.S1_3p_a_at

Hs.83672.0.S2_3p_a_at

Hs.83672.0.S4_3p_at

ILMN_1654422

M86406_at

PH_hs_0004772

TC01001955.hg

g4501892_3p_a_at

Participates

as a member of

Alpha actinins [extracellular region] (Homo sapiens)

Other forms of this molecule

ACTN2 [cytosol]

ACTN2 [platelet alpha granule lumen]

Inferred To

abpA [extracellular region] (Dictyostelium discoideum)

ain1 [extracellular region] (Schizosaccharomyces pombe)

ACTN2 [extracellular region] (Canis familiaris)

ACTN2 [extracellular region] (Dictyostelium discoideum)

ACTN2 [extracellular region] (Sus scrofa)

Actn [extracellular region] (Drosophila melanogaster)

Homologues of ACTN2 [extracellular region] (Dictyostelium discoideum)

actn2b [extracellular region] (Danio rerio)

atn-1 [extracellular region] (Caenorhabditis elegans)

Actn2 [extracellular region] (Mus musculus)

Actn2 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001265273.1, NP_001094.1, NP_001265272.1

OpenTargets

ENSG00000077522

HPA

ENSG00000077522-ACTN2

GeneCards

P35609

Ensembl

ENST00000366578, ENSG00000077522, ENSP00000355537, ENST00000542672, ENSP00000443495

PRO

P35609

Orphanet

17283

PDB

5A38, 5A36, 4D1E, 5A4B, 6SWT, 5A37, 1H8B, 1QUU, 1HCI

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23497 SP100	3	SUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) SP100 [nucleoplasm] (R-HSA-1031705)	0.666	6
UniProt:P03950 ANG	2	ANG [extracellular region] (R-HSA-5692435) ANG [cytosol] (R-HSA-9708345)	0.633	4
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.556	3
UniProt:P78560 CRADD	1	CRADD [cytosol] (R-HSA-5657970)	0.556	3
UniProt:O75604 USP2	2	USP2 [nucleoplasm] (R-HSA-5689946) USP2 [cytosol] (R-HSA-5212661)	0.556	3
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [cytosol] (R-HSA-446885) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [cytosol] (R-HSA-354096) ACTN1 [extracellular region] (R-HSA-349722)	0.556	3
UniProt:P23771 GATA3	2	PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009) GATA3 [nucleoplasm] (R-HSA-996768)	0.556	3
UniProt:P29373 CRABP2	2	SUMO-K102-CRABP2 [nucleoplasm] (R-HSA-5334813) SUMO-K102-CRABP2 [cytosol] (R-HSA-5334798)	0.556	3
UniProt:P26842 CD27	1	CD27 [plasma membrane] (R-HSA-5666994)	0.556	3
UniProt:Q92934 BAD	4	BAD [cytosol] (R-HSA-50662) p-S99-BAD [cytosol] (R-HSA-198335) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S128-BAD [cytosol] (R-HSA-217297)	0.556	3
UniProt:P47897 QARS1	2	QARS [mitochondrial matrix] (R-HSA-379592) QARS [cytosol] (R-HSA-379615)	0.556	3
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.556	3
UniProt:O75923 DYSF	1	DYSF [cytoplasmic vesicle membrane] (R-HSA-5263626)	0.454	2
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.454	2

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