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TIMP1 [extracellular region]
Stable Identifier
R-HSA-349743
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Metalloproteinase inhibitor 1
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
proMMP9 binds TIMP1 (Homo sapiens)
TIMP1 [extracellular region] (Homo sapiens)
proMMP9:TIMP1 [extracellular region] (Homo sapiens)
TIMP1 [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
TIMP1 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 positively regulates extracellular inflammatory mediators (Homo sapiens)
TNFRSF1A(41-201),TIMP1 [extracellular region] (Homo sapiens)
TIMP1 [extracellular region] (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
TIMP1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01033 TIMP1
Gene Names
TIMP1, CLGI, TIMP
Chain
signal peptide:1-23, chain:24-207
Reference Genes
BioGPS Gene:7076 TIMP1
COSMIC (genes):TIMP1 TIMP1
CTD Gene:7076 TIMP1
dbSNP Gene:7076 TIMP1
ENSEMBL:ENSG00000102265 TIMP1
HGNC:11820 TIMP1
KEGG Gene (Homo sapiens):7076 TIMP1
Monarch:7076 TIMP1
NCBI Gene:7076 TIMP1
OMIM:305370 TIMP1
Reference Transcript
RefSeq:NM_003254.2 TIMP1
Other Identifiers
11715359_a_at
11715360_x_at
1693_s_at
17103185
201666_at
3976342
3976345
3976346
3976349
3976350
3976352
3976356
3976357
3976358
3976359
7076
8167185
A_23_P62115
GE80207
GO:0000003
GO:0001775
GO:0002020
GO:0002248
GO:0002576
GO:0003674
GO:0004857
GO:0005125
GO:0005515
GO:0005575
GO:0005576
GO:0005581
GO:0005604
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0006464
GO:0006810
GO:0006950
GO:0007165
GO:0007568
GO:0008083
GO:0008150
GO:0008191
GO:0008219
GO:0008270
GO:0008283
GO:0008284
GO:0009056
GO:0009725
GO:0010033
GO:0010466
GO:0010951
GO:0016192
GO:0019221
GO:0019899
GO:0022617
GO:0030198
GO:0030234
GO:0030414
GO:0031012
GO:0031093
GO:0031410
GO:0032991
GO:0034097
GO:0040011
GO:0042060
GO:0043066
GO:0043086
GO:0043167
GO:0043226
GO:0043434
GO:0043687
GO:0044267
GO:0046872
GO:0048856
GO:0048870
GO:0051045
GO:0051216
GO:0070062
GO:0071492
GO:1901164
GO:1905049
GO:2001044
ILMN_1711566
PH_hs_0026117
g4507508_3p_s_at
Participant Of
hasMember
Platelet alpha granule contents [extracellular region]
STAT3-upregulated extracellular proteins [extracellular region]
TNFRSF1A(41-201),TIMP1 [extracellular region]
hasComponent
proMMP9:TIMP1 [extracellular region]
input
proMMP9 binds TIMP1
Other forms of this molecule
TIMP1 [platelet alpha granule lumen]
p-TIMP1 [endoplasmic reticulum lumen]
TIMP1 [endoplasmic reticulum lumen]
Inferred To
Homologues of TIMP1 [extracellular region] (Caenorhabditis elegans)
TIMP1 [extracellular region] (Bos taurus)
TIMP1 [extracellular region] (Canis familiaris)
TIMP1 [extracellular region] (Sus scrofa)
TIMP1 [extracellular region] (Xenopus tropicalis)
Timp [extracellular region] (Drosophila melanogaster)
timp-1 [extracellular region] (Caenorhabditis elegans)
Timp1 [extracellular region] (Mus musculus)
Timp1 [extracellular region] (Rattus norvegicus)
tag-225 [extracellular region] (Caenorhabditis elegans)
Cross References
RefSeq
NP_003245.1
Target Pathogen
5b354852be737e166372e95d
OpenTargets
ENSG00000102265
HPA
ENSG00000102265-TIMP1
GeneCards
P01033
Ensembl
ENSP00000218388
,
ENST00000218388
,
ENSG00000102265
PRO
P01033
PDB
6MAV
,
1UEA
,
3V96
,
6N9D
,
2J0T
,
1OO9
,
1LQN
,
1D2B
,
3MA2
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08962 CD63
3
CD63 [plasma membrane]
(R-HSA-114583)
CD63 [platelet dense granule membrane]
(R-HSA-51683)
CD63 [azurophil granule membrane]
(R-HSA-6799157)
0.691
8
UniProt:P14780 MMP9
8
MMP9(20-59) [extracellular region]
(R-HSA-1604685)
MMP9(20-106) [extracellular region]
(R-HSA-1604713)
MMP9(20-707) [extracellular region]
(R-HSA-1604376)
MMP9(60-106) [extracellular region]
(R-HSA-1604699)
MMP9(60-707) [extracellular region]
(R-HSA-1604726)
MMP9 [ficolin-1-rich granule lumen]
(R-HSA-6800973)
MMP9 [tertiary granule lumen]
(R-HSA-6800181)
MMP9(107-707) [extracellular region]
(R-HSA-668812)
0.641
3
UniProt:P27701 CD82
0.602
11
UniProt:P20908 COL5A1
72
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023664)
3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023553)
GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023513)
GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023628)
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023564)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023647)
COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022460)
3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022510)
3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022483)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022948)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022970)
5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022989)
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268653)
COL5A1(38-1838) [extracellular region]
(R-HSA-2268703)
3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268718)
3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268664)
3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region]
(R-HSA-2268667)
GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268629)
5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268644)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268663)
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268662)
GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268625)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268688)
3x4Hyp-COL5A1(38-1838) [extracellular region]
(R-HSA-2268658)
GalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268878)
3x4Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268750)
3x4Hyp-3Hyp-GalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268920)
GlcGalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268923)
3x4Hyp-5Hyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268827)
3x4Hyp-COL5A1(?-1838) [extracellular region]
(R-HSA-2268810)
3x4Hyp-3Hyp-COL5A1(?-1838) [extracellular region]
(R-HSA-2268730)
3x4Hyp-3Hyp-5Hyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268789)
5Hyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268902)
3x4Hyp-GalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268806)
COL5A1(?-1838) [extracellular region]
(R-HSA-2268801)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region]
(R-HSA-2268736)
Collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470075)
COL5A1(?-?) [extracellular region]
(R-HSA-2470043)
3,4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470136)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470169)
5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470174)
4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470078)
Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470044)
3,4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470204)
3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470172)
3x4Hyp-COL5A1(?-?) [extracellular region]
(R-HSA-2470236)
3x4Hyp-5Hyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470108)
GalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470205)
4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470065)
5-hydroxylysyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470230)
3x4Hyp-GalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470036)
5Hyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470123)
GlcGalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470088)
3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470153)
3x4Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470190)
3x4Hyp-3Hyp-5Hyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470095)
Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127312)
4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127314)
4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127346)
3,4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127396)
3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127412)
3,4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127365)
4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127429)
5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127397)
4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127350)
Collagen alpha-1(V) chain [extracellular region]
(R-HSA-375058)
5-hydroxylysyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127433)
3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region]
(R-HSA-2127371)
3x4Hyp-3Hyp-GalHyl-COL5A1(?-?) [extracellular region]
(R-HSA-2470116)
4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470112)
4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region]
(R-HSA-2470144)
3x4Hyp-3Hyp-COL5A1(?-?) [extracellular region]
(R-HSA-2470050)
0.508
2
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