Reactome | TIMP1 [extracellular region]

TIMP1 [extracellular region]

Stable Identifier

R-HSA-349743

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Metalloproteinase inhibitor 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01033 TIMP1

Gene Names

TIMP1, CLGI, TIMP

Chain

signal peptide:1-23, chain:24-207

Reference Genes

BioGPS Gene:7076 TIMP1

COSMIC (genes):TIMP1 TIMP1

CTD Gene:7076 TIMP1

dbSNP Gene:7076 TIMP1

ENSEMBL:ENSG00000102265 TIMP1

HGNC:11820 TIMP1

KEGG Gene (Homo sapiens):7076 TIMP1

Monarch:7076 TIMP1

NCBI Gene:7076 TIMP1

OMIM:305370 TIMP1

Reference Transcript

RefSeq:NM_003254.2 TIMP1

Other Identifiers

11715359_a_at

11715360_x_at

1693_s_at

17103185

201666_at

3976342

3976345

3976346

3976349

3976350

3976352

3976356

3976357

3976358

3976359

7076

8167185

A_23_P62115

GE80207

GO:0000003

GO:0001775

GO:0002020

GO:0002248

GO:0002576

GO:0003674

GO:0004857

GO:0005125

GO:0005515

GO:0005575

GO:0005576

GO:0005581

GO:0005604

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0006464

GO:0006810

GO:0006950

GO:0007165

GO:0007568

GO:0008083

GO:0008150

GO:0008191

GO:0008219

GO:0008270

GO:0008283

GO:0008284

GO:0009056

GO:0009725

GO:0010033

GO:0010466

GO:0010951

GO:0016192

GO:0019221

GO:0019899

GO:0022617

GO:0030198

GO:0030234

GO:0030414

GO:0031012

GO:0031093

GO:0031410

GO:0032991

GO:0034097

GO:0040011

GO:0042060

GO:0043066

GO:0043086

GO:0043167

GO:0043226

GO:0043434

GO:0043687

GO:0044267

GO:0046872

GO:0048856

GO:0048870

GO:0051045

GO:0051216

GO:0070062

GO:0071492

GO:1901164

GO:1905049

GO:2001044

ILMN_1711566

PH_hs_0026117

g4507508_3p_s_at

Participant Of

hasMember

hasComponent

proMMP9:TIMP1 [extracellular region]

input

proMMP9 binds TIMP1

Other forms of this molecule

TIMP1 [platelet alpha granule lumen]

p-TIMP1 [endoplasmic reticulum lumen]

TIMP1 [endoplasmic reticulum lumen]

Inferred To

Homologues of TIMP1 [extracellular region] (Caenorhabditis elegans)

TIMP1 [extracellular region] (Bos taurus)

TIMP1 [extracellular region] (Canis familiaris)

TIMP1 [extracellular region] (Sus scrofa)

TIMP1 [extracellular region] (Xenopus tropicalis)

Timp [extracellular region] (Drosophila melanogaster)

timp-1 [extracellular region] (Caenorhabditis elegans)

Timp1 [extracellular region] (Mus musculus)

Timp1 [extracellular region] (Rattus norvegicus)

tag-225 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003245.1

Target Pathogen

5b354852be737e166372e95d

OpenTargets

ENSG00000102265

HPA

ENSG00000102265-TIMP1

GeneCards

P01033

Ensembl

ENSG00000102265, ENSP00000218388, ENST00000218388

PRO

P01033

PDB

1LQN, 6N9D, 6MAV, 1UEA, 2J0T, 3V96, 1OO9, 1D2B, 3MA2

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08962 CD63	3	CD63 [plasma membrane] (R-HSA-114583) CD63 [platelet dense granule membrane] (R-HSA-51683) CD63 [azurophil granule membrane] (R-HSA-6799157)	0.691	8
UniProt:P14780 MMP9	8	MMP9(20-59) [extracellular region] (R-HSA-1604685) MMP9(20-106) [extracellular region] (R-HSA-1604713) MMP9(20-707) [extracellular region] (R-HSA-1604376) MMP9(60-106) [extracellular region] (R-HSA-1604699) MMP9(60-707) [extracellular region] (R-HSA-1604726) MMP9 [tertiary granule lumen] (R-HSA-6800181) MMP9 [ficolin-1-rich granule lumen] (R-HSA-6800973) MMP9(107-707) [extracellular region] (R-HSA-668812)	0.641	3
UniProt:P27701 CD82			0.602	11
UniProt:P20908 COL5A1	72	3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) 3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268662) GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268625) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268688) 3x4Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268658) GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268878) 3x4Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268750) 3x4Hyp-3Hyp-GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268920) GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268923) 3x4Hyp-5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268827) 3x4Hyp-COL5A1(?-1838) [extracellular region] (R-HSA-2268810) 3x4Hyp-3Hyp-COL5A1(?-1838) [extracellular region] (R-HSA-2268730) 3x4Hyp-3Hyp-5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268789) 5Hyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268902) 3x4Hyp-GalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268806) COL5A1(?-1838) [extracellular region] (R-HSA-2268801) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-1838) [extracellular region] (R-HSA-2268736) Collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470075) COL5A1(?-?) [extracellular region] (R-HSA-2470043) 3,4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470136) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470169) 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470174) 4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470078) Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470044) 3,4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470204) 3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470172) 3x4Hyp-COL5A1(?-?) [extracellular region] (R-HSA-2470236) 3x4Hyp-5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470108) GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470205) 4-Hyp 5-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470065) 5-hydroxylysyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470230) 3x4Hyp-GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470036) 5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470123) GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470088) 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470153) 3x4Hyp-GlcGalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470190) 3x4Hyp-3Hyp-5Hyl-COL5A1(?-?) [extracellular region] (R-HSA-2470095) Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127312) 4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127314) 4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127346) 3,4-Hyp 5-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127396) 3,4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127412) 3,4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127365) 4-hydroxyprolyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127429) 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127397) 4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127350) Collagen alpha-1(V) chain [extracellular region] (R-HSA-375058) 5-hydroxylysyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127433) 3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (R-HSA-2127371) 3x4Hyp-3Hyp-GalHyl-COL5A1(?-?) [extracellular region] (R-HSA-2470116) 4-Hyp Glu-Gal-Hyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470112) 4-hydroxyprolyl collagen alpha-1(V) chain C-term fragment [extracellular region] (R-HSA-2470144) 3x4Hyp-3Hyp-COL5A1(?-?) [extracellular region] (R-HSA-2470050)	0.508	2

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