LGMN degrades GC

Stable Identifier
R-HSA-350158
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
lysosomal lumen
ReviewStatus
5/5
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LGMN degrades GC
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Mammalian legumain (LGMN, asparagine-specific endoprotease) is a subfamily of cysteine proteases with no homology to other known proteases and is found in a wide range of organisms from parasites to plants and animals. LGMN requires acidic conditions for its degradative activity. Cubilin (CUBN), once released from the complex, cycles back to the cell surface. Free 25-hydroxyvitamin D (calcidiol, 25(OH)D) becomes available for further processing (Nykjaer et al. 1999).
Literature References
PubMed ID Title Journal Year
10052453 An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

Melsen, F, Christensen, EI, Jacobsen, C, Vorum, H, Nykjaer, A, Willnow, TE, Herz, J, Walther, D, Dragun, D

Cell 1999
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Input
Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of LGMN [lysosomal lumen]

Physical Entity
LGMN [lysosomal lumen] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
LGMN degrades GC (Bos taurus)
LGMN degrades GC (Rattus norvegicus)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-05-14)
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