Reactome | CASP6(24-179) [cytosol]

CASP6(24-179) [cytosol]

Stable Identifier

R-HSA-350313

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CASP6, Caspase-6 subunit p18

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P55212 CASP6

Gene Names

CASP6, MCH2

Chain

propeptide:1-23, chain:24-179, propeptide:180-193, chain:194-293

Reference Genes

BioGPS Gene:839 CASP6

COSMIC (genes):CASP6 CASP6

CTD Gene:839 CASP6

dbSNP Gene:839 CASP6

ENSEMBL:ENSG00000138794.10 CASP6

HGNC:1507 CASP6

KEGG Gene (Homo sapiens):839 CASP6

Monarch:839 CASP6

NCBI Gene:839 CASP6

OMIM:601532 CASP6

UCSC:P55212 CASP6

Reference Transcript

Other Identifiers

11736215_x_at

16978959

209790_3p_s_at

209790_PM_s_at

209790_s_at

211464_3p_x_at

211464_PM_x_at

211464_x_at

2781694

2781695

2781696

2781697

2781701

2781702

2781703

2781704

2781705

2781709

2781710

35662_at

8102311

839

A_23_P500799

GE59001

GO:0002218

GO:0002376

GO:0003824

GO:0004175

GO:0004197

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0006915

GO:0008233

GO:0008234

GO:0012501

GO:0016540

GO:0016787

GO:0023052

GO:0030154

GO:0030855

GO:0042802

GO:0043065

GO:0043226

GO:0048856

GO:0051604

GO:0060545

GO:0070269

GO:0072332

GO:0072734

GO:0097153

GO:0097194

GO:0097200

GO:0097284

GO:0098542

GO:0140096

HMNXSV003001156

ILMN_1659350

ILMN_1694877

ILMN_2367113

PH_hs_0000401

TC04001464.hg

U20536_s_at

g12653078_3p_a_at

g12653078_3p_x_at

g882255_3p_a_at

g882255_3p_x_at

Participates

as a component of

CASP6(24-179):CASP6(194-293) [cytosol] (Homo sapiens)

Other forms of this molecule

CASP6(194-293) [nucleoplasm]

CASP6(24-179) [nucleoplasm]

CASP6(194-293) [cytosol]

CASP6 (1-293) [cytosol]

Inferred To

Casp6 [cytosol] (Mus musculus)

Casp6 [cytosol] (Rattus norvegicus)

Strica [cytosol] (Drosophila melanogaster)

CASP6 [cytosol] (Bos taurus)

CASP6 [cytosol] (Sus scrofa)

Dcp-1 [cytosol] (Drosophila melanogaster)

Drice [cytosol] (Drosophila melanogaster)

casp6 [cytosol] (Xenopus tropicalis)

CASP6(24-179) [cytosol] (Canis familiaris)

CASP6(24-179) [cytosol] (Danio rerio)

CASP6(24-179) [cytosol] (Gallus gallus)

Damm [cytosol] (Drosophila melanogaster)

Decay [cytosol] (Drosophila melanogaster)

Homologues of CASP6(24-179) [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_116787.1, NP_001217.2

Guide to Pharmacology - Targets

1622

OpenTargets

ENSG00000138794

GeneCards

P55212

ZINC - Substances

CASP6_HUMAN

HPA

ENSG00000138794-CASP6

ZINC target

P55212

Ensembl

ENST00000265164, ENST00000352981, ENSP00000285333, ENSP00000265164, ENSG00000138794

PRO

P55212

Pharos - Targets

P55212

ZINC - Predictions - Purchasable

CASP6_HUMAN

PDB

3QNW, 4EJF, 3V6M, 4IYR, 4NBL, 4FXO, 6DEV, 4HVA, 4N7J, 3P4U, 3V6L, 6DEU, 4NBK, 3OD5, 3P45, 3S8E, 3S70, 3K7E, 2WDP, 3NKF, 4N5D, 4NBN, 3NR2, 4N7M, 4N6G

Interactors (216)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55212 CASP6	5	CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.865	8
UniProt:P42574 CASP3	5	CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.571	2
UniProt:Q5JUW0-3 KRBOX4			0.556	3
UniProt:P62701 RPS4X	2	RPS4X [nucleoplasm] (R-HSA-6798713) RPS4X [cytosol] (R-HSA-72375)	0.556	3
UniProt:O60479 DLX3			0.556	3
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.556	3
UniProt:P20807-4 CAPN3			0.556	3
UniProt:Q92782-2 Q927822			0.556	3
UniProt:Q86V28 Q86V28			0.556	3
UniProt:Q6PJW8-3 Q6PJW83			0.556	3
UniProt:Q96C03-3 MIEF2			0.556	3
UniProt:Q8N6M8-2 Q8N6M82			0.556	3
UniProt:P61962 DCAF7	2	Unfolded DCAF7 [cytosol] (R-HSA-6813821) DCAF7 [nucleoplasm] (R-HSA-8863312)	0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q9NTN9-3 SEMA4G			0.556	3
UniProt:A2RUH7 MBPHL			0.556	3
UniProt:Q8IZU1 FAM9A			0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q96BR5 COA7			0.556	3
UniProt:Q6DHV7-2 Q6DHV72			0.556	3
UniProt:Q9Y614 ACL7B			0.556	3
UniProt:Q49A26-4 GLYR1			0.556	3
UniProt:P0DPB6 RPAC2			0.556	3
UniProt:Q9H0W9-3 C11ORF54			0.556	3
UniProt:Q9NNX6-10 CD209			0.556	3
UniProt:Q5R372-9 RABGAP1L			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:Q8N1A6 CD033			0.556	3
UniProt:P54619 PRKAG1	2	PRKAG1 [nucleoplasm] (R-HSA-2151202) PRKAG1 [cytosol] (R-HSA-380946)	0.556	3
UniProt:P0C870 JMJD7			0.556	3
UniProt:Q49AJ0-4 Q49AJ04			0.556	3
UniProt:Q8NDH3-5 NPEPL1			0.556	3
UniProt:Q9UGL9 CRCT1			0.556	3
UniProt:Q6NXG1-3 Q6NXG13			0.556	3
UniProt:Q53FD0-2 ZC2HC1C			0.556	3
UniProt:Q5JTY5 CBWD3			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P48739 PITPNB	2	PITPNB [endoplasmic reticulum membrane] (R-HSA-1524106) PITPNB [Golgi membrane] (R-HSA-1524113)	0.556	3
UniProt:Q9NRZ9-6 HELLS			0.556	3
UniProt:Q8WW27 APOBEC4	1	APOBEC4 [nucleoplasm] (R-HSA-8875000)	0.556	3
UniProt:P47804-3 P478043			0.556	3
UniProt:Q8N365 CIART			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:O60927 PP1RB			0.556	3
UniProt:Q8TBB5-2 Q8TBB52			0.556	3
UniProt:Q8IWT0-2 ZBTB8OS			0.556	3
IntAct:EBI-25834490 CCSB			0.556	3
UniProt:Q9UJ70-2 NAGK			0.556	3
UniProt:Q9BRK5 CAB45			0.556	3
UniProt:P0DP58-2 LYNX1			0.556	3
UniProt:Q9NSI6-4 BRWD1			0.556	3
UniProt:Q53TN4 CYBRD1	1	CYBRD1 [plasma membrane] (R-HSA-917788)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
IntAct:EBI-25835814 CCSB			0.556	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.556	3
UniProt:Q96LX8 ZNF597	1	ZNF597 [nucleoplasm] (R-HSA-2127591)	0.556	3
IntAct:EBI-25836220 CCSB			0.556	3
UniProt:Q5W111-2 SPRYD7			0.556	3
UniProt:Q16609 LPAL2			0.556	3
UniProt:Q9H8K7 PAAT			0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q494V2-2 CFAP100			0.556	3
UniProt:Q9NX94 WBP1L			0.556	3
UniProt:Q9UIK5-2 Q9UIK52			0.556	3
UniProt:P26998 CRBB3			0.556	3
UniProt:O43548 TGM5	1	TGM5 [plasma membrane] (R-HSA-6814176)	0.556	3
UniProt:Q8WUD1-2 Q8WUD12			0.556	3
UniProt:Q9BZQ2 SHP1L			0.556	3
UniProt:Q66K80 RUAS1			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q13347 EIF3I	1	EIF3I [cytosol] (R-HSA-72536)	0.556	3
UniProt:Q9H7X0 NAA60			0.556	3
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.556	3
UniProt:Q9NU02 ANKE1			0.556	3
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.556	3
IntAct:EBI-25835277 CCSB			0.556	3
UniProt:Q3SXR2 CC036			0.556	3
UniProt:Q8NCQ7-2 Q8NCQ72			0.556	3
UniProt:A0A384MDV8 A0A384MDV8			0.556	3
UniProt:Q53NU3 Q53NU3			0.556	3
UniProt:Q96A09 TET5B			0.556	3
UniProt:Q7Z3B4 NUP54	2	NUP54 [cytosol] (R-HSA-9634221) NUP54 [nuclear envelope] (R-HSA-157724)	0.556	3
UniProt:Q9NQ89 CL004			0.556	3
UniProt:P09525 ANXA4			0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q9UK76 JUPI1			0.556	3
UniProt:Q96JB6 LOXL4	3	LOXL4(25-?) [extracellular region] (R-HSA-2022087) LOXL4 [extracellular region] (R-HSA-2022127) LOXL4(?-756) [extracellular region] (R-HSA-2022098)	0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	3
UniProt:A0A0A0MR05 A0A0A0MR05			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
IntAct:EBI-25834975 CCSB			0.556	3
UniProt:Q96Q83-2 ALKBH3			0.556	3
UniProt:Q8N0U6 CF218			0.556	3
IntAct:EBI-25834617 CCSB			0.556	3
IntAct:EBI-25835824 RZPDO834E0719D			0.556	3
UniProt:P22307-3 P223073			0.556	3
UniProt:Q5T2L2 AKCL1			0.556	3
UniProt:Q7Z6I5 SPT12			0.556	3
UniProt:Q9BT25 HAUS8	1	HAUS8 [cytosol] (R-HSA-8855198)	0.556	3
UniProt:Q496A3 SPAS1			0.556	3
UniProt:Q96EY1-3 DNAJA3			0.556	3
UniProt:Q96Q07-2 BTBD9			0.556	3
UniProt:P01011 SERPINA3	4	SERPINA3 [platelet alpha granule lumen] (R-HSA-8848913) SERPINA3 [azurophil granule lumen] (R-HSA-6798754) SERPINA3 [extracellular region] (R-HSA-6806173) SERPINA3 [secretory granule lumen] (R-HSA-6801018)	0.556	3
UniProt:Q58EX7-2 Q58EX72			0.556	3
UniProt:B7Z3E8 B7Z3E8			0.556	3
IntAct:EBI-25836264 CCSB			0.556	3
UniProt:Q8N5J2-3 MINDY1			0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:P02458-1 COL2A1			0.556	3
UniProt:Q86WT6-2 TRIM69			0.556	3
UniProt:Q9H2C1 LHX5			0.556	3
UniProt:Q658K8 EF1DL			0.556	3
UniProt:Q9UKG9-2 Q9UKG92			0.556	3
UniProt:O60902-3 SHOX2			0.556	3
UniProt:Q99447 PCYT2	1	PCYT2 [endoplasmic reticulum membrane] (R-HSA-1498781)	0.556	3
UniProt:Q9Y3D0 CIAO2B	1	FAM96B [cytosol] (R-HSA-2161124)	0.556	3
UniProt:Q1L5Z9 LONF2			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:P49459 UBE2A	3	UBE2A [nucleoplasm] (R-HSA-8852048) Ub-C88-UBE2A [nucleoplasm] (R-HSA-8864186) UBE2A [cytosol] (R-HSA-947617)	0.556	3
UniProt:Q8N128-2 FAM177A1			0.556	3
UniProt:Q6IN84-2 MRM1			0.556	3
UniProt:Q8N5U6 RNF10			0.556	3
UniProt:Q15382 RHEB	2	RHEB [endosome membrane] (R-HSA-5656350) RHEB [lysosomal membrane] (R-HSA-165190)	0.556	3
UniProt:Q8IYG6 LRC56			0.556	3
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.556	3
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.556	3
UniProt:P27815-4 PDE4A			0.556	3
UniProt:Q9Y303-2 AMDHD2			0.556	3
UniProt:Q66PJ3-4 ARL6IP4			0.556	3
UniProt:Q8N4N3-2 KLHL36			0.556	3
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.556	3
UniProt:Q14181 POLA2	1	POLA2 [nucleoplasm] (R-HSA-68493)	0.556	3
IntAct:EBI-25835866 CCSB			0.556	3
UniProt:Q9UH77 KLHL3	1	KLHL3 [cytosol] (R-HSA-8863198)	0.556	3
UniProt:Q3KNS6-3 Q3KNS63			0.556	3
UniProt:O00423 EMAL1			0.556	3
UniProt:O00303 EIF3F	1	EIF3F [cytosol] (R-HSA-72540)	0.556	3
UniProt:Q8NA23-2 Q8NA232			0.556	3
UniProt:Q3SX64 OD3L2			0.556	3
IntAct:EBI-25836274 CCSB			0.556	3
UniProt:Q92797-2 Q927972			0.556	3
UniProt:Q13885 TUBB2A	6	TUBB2A folding intermediate [cytosol] (R-HSA-392802) TUBB2A unfolded [cytosol] (R-HSA-392776) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.556	3
UniProt:P17655 CAPN2	2	CAPN2 [cytosol] (R-HSA-8848630) CAPN2 [plasma membrane] (R-HSA-8863405)	0.556	3
UniProt:Q15742-2 Q157422			0.556	3
UniProt:Q9BPU6 DPYSL5	3	p-Y-DPYSL5 [cytosol] (R-HSA-399786) DPYSL5 [cytosol] (R-HSA-398138) p-S534-DPYSL5 [cytosol] (R-HSA-399793)	0.556	3
UniProt:Q9NR46 SHLB2			0.556	3
UniProt:Q9HAV0 GNB4	4	GNB4 [plasma membrane] (R-HSA-164326) Unfolded GNB4 [cytosol] (R-HSA-6814201) Partially folded GNB4 [cytosol] (R-HSA-8850525) GNB4 [cytosol] (R-HSA-6814417)	0.556	3
IntAct:EBI-25835770 CCSB			0.556	3
UniProt:P27338 MAOB	1	MAOB [mitochondrial outer membrane] (R-HSA-141194)	0.556	3
UniProt:P36639-4 NUDT1	1	NUDT1-4 [cytosol] (R-HSA-2395813)	0.556	3
UniProt:Q6ZNL6 FGD5	1	FGD5 [cytosol] (R-HSA-9714447)	0.556	3
UniProt:O00257-3 CBX4			0.556	3
UniProt:Q9P1Q0-4 VPS54			0.556	3
UniProt:Q6N063-2 Q6N0632			0.556	3
UniProt:Q6NXT2 H3C			0.556	3
UniProt:Q05CR2 Q05CR2			0.556	3
UniProt:A6NJ78-4 METTL15			0.556	3
IntAct:EBI-25835760 CCSB			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:P09496-2 CLTA			0.556	3
UniProt:P34949-2 P349492			0.556	3
UniProt:Q8N1A0 KT222			0.556	3
UniProt:Q969L2 MAL2			0.556	3
UniProt:Q92613 JADE3	1	PHF16 [nucleoplasm] (R-HSA-3321851)	0.556	3
UniProt:P61925 IPKA			0.556	3
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.556	3
IntAct:EBI-25835796 CCSB			0.556	3
UniProt:P36954 POLR2I	1	POLR2I [nucleoplasm] (R-HSA-63525)	0.556	3
UniProt:Q9C004 SPY4			0.556	3
UniProt:Q9HD47-3 RANGRF			0.556	3
UniProt:P54687-4 P546874			0.556	3
UniProt:Q9BUL5 PHF23			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:P54274-2 TERF1			0.556	3
UniProt:Q8NFH3 NUP43	2	NUP43 [nuclear envelope] (R-HSA-157739) NUP43 [cytosol] (R-HSA-376243)	0.556	3
UniProt:Q8NFH4 NUP37	2	NUP37 [nuclear envelope] (R-HSA-157745) NUP37 [cytosol] (R-HSA-376237)	0.556	3
UniProt:Q96EW2-2 Q96EW22			0.556	3
UniProt:Q6DKI2 LEG9C			0.556	3
UniProt:Q96JL9-2 Q96JL92			0.556	3
UniProt:Q96MA6 AK8	1	AK8 [cytosol] (R-HSA-6788788)	0.556	3
UniProt:Q99966 CITED1	1	CITED1 [nucleoplasm] (R-HSA-8864301)	0.556	3
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.556	3
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:Q13901 C1D	1	C1D [nucleoplasm] (R-HSA-6791515)	0.556	3
UniProt:Q04206 RELA	6	polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.556	3
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:Q14032 BAAT	2	BAAT [cytosol] (R-HSA-159392) BAAT [peroxisomal matrix] (R-HSA-193517)	0.556	3
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:Q8WUX9 CHMP7	2	CHMP7 [cytosol] (R-HSA-917703) CHMP7 [endosome membrane] (R-HSA-9631168)	0.556	3
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.556	3
UniProt:Q9BV20 MRI1	1	MRI1 [cytosol] (R-HSA-1237095)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:P37840 SNCA	4	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:P06276 BCHE	2	BCHE [extracellular region] (R-HSA-434469) BCHE [plasma membrane] (R-HSA-3640835)	0.556	3
UniProt:P06727 APOA4	5	APOA4(21-94) [extracellular region] (R-HSA-976882) APOA4 [early endosome] (R-HSA-2429647) APOA4 [cytosol] (R-HSA-2395773) APOA4 [endoplasmic reticulum lumen] (R-HSA-174667) APOA4 [extracellular region] (R-HSA-174701)	0.556	3
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.556	3
UniProt:Q86US8 SMG6	1	SMG6 [cytosol] (R-HSA-927851)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:Q00169 PITPNA	1	PITPNA [cytosol] (R-HSA-418391)	0.556	3
UniProt:Q9NQ88 TIGAR	1	TIGAR [cytosol] (R-HSA-5628829)	0.556	3
UniProt:P41222 PTGDS	1	PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)	0.556	3
UniProt:Q9NSA1 FGF21	2	FGF21 [cytosol] (R-HSA-6784692) FGF21 [extracellular region] (R-HSA-189909)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.556	3
UniProt:P18848 ATF4	1	ATF4 [nucleoplasm] (R-HSA-381016)	0.556	3
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.556	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3

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