Caspase-mediated cleavage of vimentin at TNLD (429)

Stable Identifier
R-HSA-350318
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase-mediated cleavage of vimentin at TNLD (429)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This clevage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Caspase-6 recognizes and cleaves C terminal side of Asp-429.
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of active caspase-6 [cytosol]

Physical Entity
active caspase-6 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of vimentin at TNLD (429) (Bos taurus)
Caspase-mediated cleavage of vimentin at TNLD (429) (Canis familiaris)
Caspase-mediated cleavage of vimentin at TNLD (429) (Danio rerio)
Caspase-mediated cleavage of vimentin at TNLD (429) (Gallus gallus)
Caspase-mediated cleavage of vimentin at TNLD (429) (Mus musculus)
Caspase-mediated cleavage of vimentin at TNLD (429) (Rattus norvegicus)
Caspase-mediated cleavage of vimentin at TNLD (429) (Sus scrofa)
Caspase-mediated cleavage of vimentin at TNLD (429) (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-18)
Cite Us!