Caspase-mediated cleavage of vimentin at TNLD (429)

Stable Identifier
R-HSA-350318
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Caspase-mediated cleavage of vimentin at TNLD (429)
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Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This clevage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Caspase-6 recognizes and cleaves C terminal side of Asp-429.

Literature References
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-6 [cytosol]
Physical Entity
active caspase-6 [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
Orthologous Events
Caspase-mediated cleavage of vimentin at TNLD (429) (Bos taurus)
Caspase-mediated cleavage of vimentin at TNLD (429) (Canis familiaris)
Caspase-mediated cleavage of vimentin at TNLD (429) (Danio rerio)
Caspase-mediated cleavage of vimentin at TNLD (429) (Gallus gallus)
Caspase-mediated cleavage of vimentin at TNLD (429) (Mus musculus)
Caspase-mediated cleavage of vimentin at TNLD (429) (Rattus norvegicus)
Caspase-mediated cleavage of vimentin at TNLD (429) (Sus scrofa)
Caspase-mediated cleavage of vimentin at TNLD (429) (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2008-05-18)