Reactome | Caspase mediated cleavage of vimentin at IDVD (259)

Caspase mediated cleavage of vimentin at IDVD (259)

Stable Identifier

R-HSA-350319

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Caspase mediated cleavage of vimentin at IDVD (259)

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Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This clevage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Asp259 is recognized and cleaved by caspase-6 (Byun et al., 2001).

Literature References

PubMed ID	Title	Journal	Year
11423904	Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis Byun, Y, Chen, F, Chang, R, Trivedi, M, Green, KJ, Cryns, VL	Cell Death Differ	2001