Antizyme OAZ binds to Ornithine decarboxylase

Stable Identifier
R-HSA-350567
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Antizyme is a non-competitive inhibitor of ODC that is synthesized in response to an increase in polyamine concentration. Tight binding of the antizyme to the ODC monomer forming a heterodimer prevents enzymatic activity. The region of antizyme interacting with ODC is contained in a section involving residues 106–212 in the COOH-terminal half of the antizyme molecule. The induction of antizyme thus leads to a loss of active ODC protein (Pegg, 2006 and references cited in that review).

Literature References
PubMed ID Title Journal Year
12359729 Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase

Chen, H, MacDonald, A, Coffino, P

J Biol Chem 2002
9132164 Molcecular cloning of human antizyme cDNA

Yang, D, Takii, T, Hayashi, H, Itoh, S, Hayashi, M, Onozaki, K

Biochem Mol Biol Int 1996
12660156 Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

Zhang, M, Pickart, CM, Coffino, P

EMBO J 2003
7811704 Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme

Tewari, DS, Qian, Y, Thornton, RD, Pieringer, J, Taub, R, Mochan, E, Tewari, M

Biochim Biophys Acta 1994
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