Reactome | NQO1 interaction with ODC

NQO1 interaction with ODC

Stable Identifier

R-HSA-350578

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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A novel pathway has been described for ODC degradation during oxidative stress, which is regulated by NAD(P)H quinone oxidoreductase (NQO1). In this pathway, the 20S proteasome has been shown to degrade unfolded ODC monomers. This event does not require the COOH-terminal domain. NQO1 binds to ODC and stabilizes it. If this interaction is disrupted with dicoumarol, it sensitizes ODC monomers to degradation by the 20S proteasome independent of both antizyme and ubiquitin. The details of the role of this pathway remains to be determined, but it could be involved in the nascent ODC chain turnover.

Literature References

PubMed ID	Title	Journal	Year
16205122	Mechanisms of protein degradation: an odyssey with ODC Shaul, Y, Kahana, C, Asher, G	Cell Cycle	2005
15749015	20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1 Shaul, Y, Kahana, C, Bercovich, Z, Tsvetkov, P, Asher, G	Mol Cell	2005