Antizyme inhibitor binds to OAZ and stablizes ODC complex

Stable Identifier
R-HSA-350600
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Antizyme inhibitor blocks the effects of antizyme on ODC. It has substantial similarity to ODC itself but has no ODC activity. It binds to antizyme more tightly than ODC displacing ODC from the antizyme-ODC complex. Recent studies have shown that antizyme inhibitor is able to disrupt the interaction between all forms of mammalian antizyme and ODC (Murakami et al., 1996, Nilsson et al., 2000, Mangold and Leberer, 2005).

Literature References
PubMed ID Title Journal Year
9349715 Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor

Koguchi, K, Kobayashi, S, Hayashi, T, Matsufuji, S, Murakami, Y, Hayashi, S

Biochim Biophys Acta 1997
17900240 Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase

Kanerva, K, Mäkitie, LT, Pelander, A, Heiskala, M, Andersson, LC

Biochem J 2008
15491992 Degradation of antizyme inhibitor, an ornithine decarboxylase homologous protein, is ubiquitin-dependent and is inhibited by antizyme

Bercovich, Z, Kahana, C

J Biol Chem 2004
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