Reactome | Agmatine + H2O <=> putrescine + urea

Agmatine + H2O <=> putrescine + urea

Stable Identifier

R-HSA-350604

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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As it hydrolyzes a guanidino group within agmatine and also contains signature amino acid residues that act as ligand binding sites for the potential Mn(++) cofactor, agmatinase is classified as a member of the arginase superfamily (Morris, 2003).

Literature References

PubMed ID	Title	Journal	Year
11914032	Cloning and characterization of human agmatinase Iyer, RK, Cederbaum, SD, Tsoa, RW, Kim, HK, Grody, WW	Mol Genet Metab	2002
11804860	Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus Cook, WJ, Burwell, TJ, Mistry, SK, Morris SM, Jr, Chambers, RM, Rudolph-Owen, L, Spaltmann, F	Am J Physiol Gastrointest Liver Physiol	2002