Reactome | SOD1 [extracellular region]

SOD1 [extracellular region]

Stable Identifier

R-HSA-350705

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Superoxide dismutase (Cu-Zn)

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External Reference Information

External Reference

UniProt:P00441 SOD1

Gene Names

SOD1

Chain

initiator methionine:1, chain:2-154

Reference Genes

BioGPS Gene:6647 SOD1

COSMIC (genes):SOD1 SOD1

CTD Gene:6647 SOD1

dbSNP Gene:6647 SOD1

ENSEMBL:ENSG00000142168 SOD1

HGNC:11179 SOD1

KEGG Gene (Homo sapiens):6647 SOD1

Monarch:6647 SOD1

NCBI Gene:6647 SOD1

OMIM:147450 SOD1

Reference Transcript

RefSeq:NM_000454.4 SOD1

Other Identifiers

0000130315

11716935_a_at

11756351_x_at

11757619_x_at

1401

16922102

1AZV

1BA9

1DSW

1FUN

1HL4

1HL5

1KMG

1L3N

1MFM

1N18

1N19

1OEZ

1OZT

1OZU

1P1V

1PTZ

1PU0

1RK7

1SOS

1SPD

1UXL

1UXM

200642_at

2AF2

2C9S

2C9U

2C9V

2GBT

2GBU

2GBV

2LU5

2MP3

2NAM

2NNX

2R27

2V0A

2VR6

2VR7

2VR8

2WKO

2WYT

2WYZ

2WZ0

2WZ5

2WZ6

2XJK

2XJL

2ZKW

2ZKX

2ZKY

36620_at

3917873

3917874

3917882

3917888

3917890

3917892

3917893

3917894

3917895

3917896

3917897

3917911

3CQP

3CQQ

3ECU

3ECV

3ECW

3GQF

3GTV

3GZO

3GZP

3GZQ

3H2P

3H2Q

3HFF

3K91

3KH3

3KH4

3LTV

3QQD

3RE0

3T5W

4A7G

4A7Q

4A7S

4A7T

4A7U

4A7V

4B3E

4BCY

4BCZ

4BD4

4FF9

4MCM

4MCN

4NIN

4NIO

4NIP

4OH2

4SOD

4XCR

5DLI

5IIW

5J07

5J0C

5J0F

5J0G

5K02

5O3Y

5O40

5U9M

5WMJ

5WOR

5YTO

5YTU

5YUL

6647

6B79

6FFK

6FLH

6FOI

6FOL

6FON

6FP6

8068168

8670

A_14_P105406

A_23_P154840

A_24_P151464

AAB05661

AAB05662

AAB59626

AAB59627

AAC41773

AAH01034

AAL15444

AAP35322

AAR21563

AAV80422

ABL96616

ACJ13715

AK312116

AP000253

AY049787

AY450286

AY835629

BAG35052

BC001034

BT006676

CAA25915

CAA25916

CAA25917

CAA25918

CAA25919

CAA26182

CAA64520

CAB008670

CAG29351

CAG46542

CCDS33536

CH471079

CR450355

CR541742

EAX09889

EAX09890

EF151142

ENSG00000142168

ENSP00000270142

ENST00000270142

ENST00000270142.10

EntrezGene:6647

EntrezGene:SOD1

EU794661

g4507148_3p_at

GE79683

GO:0000003

GO:0000187

GO:0000302

GO:0000303

GO:0000902

GO:0001541

GO:0001819

GO:0001890

GO:0001895

GO:0001975

GO:0002262

GO:0002376

GO:0002576

GO:0003013

GO:0003674

GO:0004784

GO:0005507

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005758

GO:0005759

GO:0005764

GO:0005773

GO:0005777

GO:0005829

GO:0005886

GO:0006464

GO:0006629

GO:0006749

GO:0006790

GO:0006801

GO:0006810

GO:0006879

GO:0006950

GO:0006979

GO:0007009

GO:0007010

GO:0007165

GO:0007283

GO:0007566

GO:0007568

GO:0007569

GO:0007605

GO:0007626

GO:0008089

GO:0008090

GO:0008150

GO:0008217

GO:0008219

GO:0008270

GO:0009058

GO:0009408

GO:0009790

GO:0010033

GO:0016192

GO:0016209

GO:0016491

GO:0019226

GO:0019430

GO:0019899

GO:0030141

GO:0030154

GO:0030346

GO:0030705

GO:0031045

GO:0031410

GO:0031667

GO:0032287

GO:0032839

GO:0032930

GO:0032991

GO:0033081

GO:0034465

GO:0034599

GO:0034641

GO:0035722

GO:0035865

GO:0040007

GO:0040014

GO:0042493

GO:0042542

GO:0042554

GO:0042592

GO:0042802

GO:0042803

GO:0043005

GO:0043025

GO:0043065

GO:0043066

GO:0043085

GO:0043087

GO:0043167

GO:0043226

GO:0043524

GO:0044281

GO:0045471

GO:0045541

GO:0045859

GO:0046620

GO:0046677

GO:0046688

GO:0046716

GO:0046872

GO:0048365

GO:0048538

GO:0048678

GO:0048856

GO:0050665

GO:0050728

GO:0050766

GO:0050877

GO:0051087

GO:0051186

GO:0051881

GO:0055114

GO:0060047

GO:0060052

GO:0060087

GO:0060088

GO:0061024

GO:0070062

GO:0071276

GO:0071318

GO:0072593

GO:0097332

GO:1902177

GO:1904115

H7BYH4

HEL-S-44

HGNC:11179

HPA001401

ILMN_1662438

IPR001424

IPR018152

IPR024134

IPR036423

L44135

L44136

L44137

L44139

L44746

L46374

L46375

LRG_652

LRG_652t1

MIM:105400

MIM:147450

NM_000454

NP_000445

PF00080

PH_hs_0025933

PR00068

SOD1

SOD1-201

TC21000111.hg

UPI0000000C20

V9HWC9

X01780

X01781

X01782

X01783

X01784

X02317

X02317_at

X95228

Participant Of

hasMember

Platelet releasate cytosolic proteins [extracellular region]

Other forms of this molecule

SOD1 [mitochondrial intermembrane space]

2xHC-SOD1 [mitochondrial intermembrane space]

SOD1 [cytosol]

2xHC-SOD1 [cytosol]

Inferred To

Homologues of SOD1 [extracellular region] (Dictyostelium discoideum)

SOD1 [extracellular region] (Bos taurus)

SOD1 [extracellular region] (Caenorhabditis elegans)

SOD1 [extracellular region] (Canis familiaris)

SOD1 [extracellular region] (Danio rerio)

SOD1 [extracellular region] (Dictyostelium discoideum)

SOD1 [extracellular region] (Drosophila melanogaster)

SOD1 [extracellular region] (Mus musculus)

SOD1 [extracellular region] (Rattus norvegicus)

SOD1 [extracellular region] (Saccharomyces cerevisiae)

SOD1 [extracellular region] (Schizosaccharomyces pombe)

SOD1 [extracellular region] (Sus scrofa)

SOD1 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_000445.1

OpenTargets

ENSG00000142168

GeneCards

P00441

ZINC target

P00441

PRO

P00441

Orphanet

15536

HMDB Protein

HMDBP02053

PDB

2WZ6, 4A7T, 1AZV, 1KMG, 5J0C, 3HFF, 5WMJ, 4A7V, 6FON, 1HL5, 2XJL, 2WYT, 2WZ0, 3CQQ, 3KH4, 5YTU, 3GQF, 4A7Q, 6FOI, 6A9O, 6B79, 2LU5, 1N19, 2GBU, 3GTV, 3LTV, 4BCZ, 1PU0, 5O40, 6FFK, 5K02, 2C9U, 2NNX, 2R27, 1OZU, 4BCY, 3ECU, 2VR8, 2ZKY, 4OH2, 1UXL, 4NIP, 2ZKW, 3K91, 3GZO, 1BA9, 4MCN, 1L3N, 2VR6, 4NIN, 3GZQ, 2AF2, 4FF9, 5J0G, 3H2Q, 2NAM, 1SPD, 6FLH, 4A7U, 6FP6, 2WYZ, 2WZ5, 5YUL, 1SOS, 1HL4, 6DTK, 4XCR, 3KH3, 6FOL, 2XJK, 2GBV, 5J07, 4A7S, 1DSW, 1N18, 5YTO, 3RE0, 2GBT, 4A7G, 3CQP, 5DLI, 3ECW, 5IIW, 4BD4, 1PTZ, 5O3Y, 1OZT, 5WOR, 4B3E, 2C9V, 3ECV, 1FUN, 3QQD, 1OEZ, 2VR7, 2C9S, 2WKO, 1MFM, 3GZP, 1UXM, 1RK7, 3T5W, 4NIO, 2ZKX, 4SOD, 3H2P, 2V0A, 2MP3, 1P1V, 4MCM, 5U9M, 5J0F

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00441 SOD1	5	SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.974	19
UniProt:P20029 Hspa5	6	78 kDa glucose-regulated protein precursor [endoplasmic reticulum lumen] (R-MMU-351326) 78 kDa glucose-regulated protein precursor [extracellular region] (R-MMU-351324) HSPA5 [cytosol] (R-MMU-5252115) HSPA5 [nucleoplasm] (R-MMU-5252042) HSPA5 [endoplasmic reticulum membrane] (R-MMU-351315) HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane] (R-MMU-985498)	0.688	7
UniProt:P26339	2	CHGA(19-94) [extracellular region] (R-MMU-6808524) CHGA(370-390) [extracellular region] (R-MMU-6808568)	0.625	5
UniProt:P30044 PRDX5			0.612	10
UniProt:P16014	2	CHGB [endoplasmic reticulum lumen] (R-MMU-8956734) phospho-p-CHGB [endoplasmic reticulum lumen] (R-MMU-8956928)	0.602	6
UniProt:O14618 CCS	2	CCS [cytosol] (R-HSA-3299714) CCS [mitochondrial intermembrane space] (R-HSA-3777060)	0.564	2
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.564	3
UniProt:P07686 HEXB	10	HEXB(315-556) [lysosomal lumen] (R-HSA-1605605) HEXB(122-311) [lysosomal lumen] (R-HSA-1605777) HEXB(122-311) [azurophil granule lumen] (R-HSA-6799125) HEXB(315-556) [azurophil granule lumen] (R-HSA-6799134) HEXB(122-311) [extracellular region] (R-HSA-6806190) HEXB(315-556) [extracellular region] (R-HSA-6806188) HEXB I322Kfs5 [lysosomal lumen] (R-HSA-3700889) HEXB M26Cfs5 [lysosomal lumen] (R-HSA-3700843) HEXB R284* [lysosomal lumen] (R-HSA-3700930) HEXB S62L [lysosomal lumen] (R-HSA-3700901)	0.527	2
UniProt:Q99497 PARK7	7	PARK7 [nucleoplasm] (R-HSA-3900141) SUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) Misfolded PARK7 [cytosol] (R-HSA-9641100) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.527	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.499	3
UniProt:Q8TCX1 DYNC2LI1	2	DYNC2LI1 [cilium] (R-HSA-5624862) DYNC2LI1 [ciliary tip] (R-HSA-5625333)	0.499	3