Reactome | TLN1 [cytosol]

TLN1 [cytosol]

Stable Identifier

R-HSA-350713

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Talin-1

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Locations in the PathwayBrowser for interactor UniProt:P18206 VCL

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - Calpain2 (m-Calpain) cleaves TLN1 (Talin-1) (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)
- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of Talin-1 (Homo sapiens)
        
        TLN1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y490 TLN1

Gene Names

TLN1, KIAA1027, TLN

Chain

chain:1-2541

Reference Genes

BioGPS Gene:7094 TLN1

COSMIC (genes):TLN1 TLN1

CTD Gene:7094 TLN1

dbSNP Gene:7094 TLN1

ENSEMBL:ENSG00000137076 TLN1

ENSEMBL_homo_sapiens_GENE:ENSG00000137076.22 TLN1

HGNC:11845 TLN1

KEGG Gene (Homo sapiens):7094 TLN1

Monarch:7094 TLN1

NCBI Gene:7094 TLN1

OMIM:186745 TLN1

UCSC:Q9Y490 TLN1

Reference Transcript

RefSeq:NM_006289.3 TLN1

Other Identifiers

11743123_a_at

11743124_s_at

17093762

203254_PM_s_at

203254_s_at

3204745

3204746

3204747

3204748

3204749

3204750

3204751

3204752

3204754

3204755

3204756

3204757

3204758

3204759

3204760

3204763

3204764

3204765

3204766

3204767

3204768

3204769

3204770

3204771

3204772

3204773

3204774

3204775

3204776

3204777

3204780

3204781

3204782

3204783

3204784

3204785

3204786

3204787

3204788

3204789

3204790

3204791

3204792

3204793

3204794

3204796

3204797

3204798

3204799

3204801

3204803

3204806

3204808

3204810

3204812

3204813

3204814

3204815

3204817

3204819

3204821

32166_at

45517_s_at

63588_at

7094

73587_at

8161056

A_23_P9166

A_24_P196851

GE53702

GO:0001726

GO:0001786

GO:0003779

GO:0005178

GO:0005198

GO:0005200

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005912

GO:0005925

GO:0007010

GO:0007043

GO:0007044

GO:0007155

GO:0007229

GO:0008092

GO:0008289

GO:0009986

GO:0016020

GO:0017166

GO:0023052

GO:0030274

GO:0030866

GO:0032587

GO:0033622

GO:0034330

GO:0035091

GO:0042060

GO:0042995

GO:0043226

GO:0045296

GO:0051015

GO:0051893

GO:0065003

GO:0070062

GO:0070161

GO:0070527

GO:0098609

HMNXSV003012266

ILMN_1696643

PH_hs_0018189

TC09001059.hg

g5454129_3p_s_at

Participates

as a component of

as an input of

as a member of

Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)

as an output of

Other forms of this molecule

TLN1 [extracellular region]

TLN1(434-2541) [cytosol]

TLN1(1-433) [cytosol]

Inferred To

Tln1 [cytosol] (Mus musculus)

Tln1 [cytosol] (Rattus norvegicus)

rhea [cytosol] (Drosophila melanogaster)

talB [cytosol] (Dictyostelium discoideum)

tln-1 [cytosol] (Caenorhabditis elegans)

tln1 [cytosol] (Xenopus tropicalis)

TLN1 [cytosol] (Bos taurus)

TLN1 [cytosol] (Canis familiaris)

TLN1 [cytosol] (Gallus gallus)

TLN1 [cytosol] (Sus scrofa)

Ghost homologue of TLN1 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_006280.3

OpenTargets

ENSG00000137076

HPA

ENSG00000137076-TLN1

GeneCards

Q9Y490

Ensembl

ENSG00000137076, ENSP00000316029, ENST00000314888

PRO

Q9Y490

Pharos - Targets

Q9Y490

PDB

2MWN, 6R9T, 1SYQ, 4DJ9

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05106 ITGB3	3	p-T779-ITGB3 [plasma membrane] (R-HSA-432107) ITGB3(27-?) [platelet alpha granule membrane] (R-HSA-114512) ITGB3 [plasma membrane] (R-HSA-57600)	0.715	5
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.623	2
UniProt:O60331 PIP5K1C	1	PIP5K1C [cytosol] (R-HSA-392427)	0.611	8
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.597	5
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.59	2
UniProt:Q2M1Z3 ARHGAP31	1	ARHGAP31 [cytosol] (R-HSA-195204)	0.59	2
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.544	2
UniProt:Q5T7N3 KANK4			0.527	3
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.527	2
UniProt:P53004 BLVRA	1	BLVRA [cytosol] (R-HSA-189390)	0.527	2
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P18206 VCL	8	VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713472) VCL(1-811)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713480) VCL(95 kDa) [cytosol] (R-HSA-9861471) VCL [specific granule lumen] (R-HSA-6799711) VCL [secretory granule lumen] (R-HSA-6801010) VCL [extracellular region] (R-HSA-350736) VCL [ficolin-1-rich granule lumen] (R-HSA-6800985) VCL [cytosol] (R-HSA-350753)	0.527	2

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