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PLEK [cytosol]
Stable Identifier
R-HSA-350715
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Pleckstrin
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of platelet cytosolic components (Homo sapiens)
Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
PLEK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08567 PLEK
Gene Names
PLEK, P47
Chain
chain:1-350
Reference Genes
BioGPS Gene:5341 PLEK
COSMIC (genes):PLEK PLEK
CTD Gene:5341 PLEK
dbSNP Gene:5341 PLEK
ENSEMBL:ENSG00000115956 PLEK
HGNC:9070 PLEK
Monarch:5341 PLEK
NCBI Gene:5341 PLEK
OMIM:173570 PLEK
UCSC:P08567 PLEK
Reference Transcript
RefSeq:NM_002664.2 PLEK
Other Identifiers
11742859_a_at
11754474_a_at
16880942
203470_PM_s_at
203470_s_at
203471_PM_s_at
203471_s_at
2486817
2486819
2486820
2486823
2486829
2486831
2486832
2486833
2486836
2486837
2486838
2486839
2486840
37328_at
5341
7896724
8042391
A_14_P129362
GE59697
GO:0002244
GO:0002576
GO:0005080
GO:0005515
GO:0005576
GO:0005737
GO:0005829
GO:0005886
GO:0006629
GO:0006904
GO:0007010
GO:0007155
GO:0007229
GO:0010572
GO:0010920
GO:0010925
GO:0016020
GO:0016192
GO:0030030
GO:0030036
GO:0030154
GO:0030836
GO:0030845
GO:0030866
GO:0031529
GO:0032233
GO:0032587
GO:0033625
GO:0035556
GO:0042803
GO:0043325
GO:0045744
GO:0046488
GO:0050849
GO:0060305
GO:0070493
GO:0070527
GO:0070528
GO:0070560
HMNXSV003046590
Hs.77436.0.A1_3p_a_at
ILMN_1795762
PH_hs_0004463
TC02000398.hg
X07743_at
g4505878_3p_a_at
Participates
as a member of
Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
Other forms of this molecule
PLEK [extracellular region]
Inferred To
CG18566 [cytosol]
(Drosophila melanogaster)
Homologues of PLEK [cytosol]
(Dictyostelium discoideum)
plek [cytosol]
(Danio rerio)
plek [cytosol]
(Xenopus tropicalis)
Plek [cytosol]
(Mus musculus)
Plek [cytosol]
(Rattus norvegicus)
PLEK [cytosol]
(Bos taurus)
PLEK [cytosol]
(Canis familiaris)
PLEK [cytosol]
(Dictyostelium discoideum)
PLEK [cytosol]
(Gallus gallus)
PLEK [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000234313
,
ENSP00000234313
OpenTargets
ENSG00000115956
HPA
ENSG00000115956-PLEK
PRO
P08567
Pharos - Targets
P08567
PDB
2I5F
,
1XX0
,
1ZM0
,
1X05
,
2CSO
,
1W4M
,
2I5C
,
1PLS
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51659 HSD17B4
4
HSD17B4(1-736) [peroxisomal matrix]
(R-HSA-192322)
HSD17B4 [cytosol]
(R-HSA-9033102)
HSD17B4(1-311) [peroxisomal matrix]
(R-HSA-9033503)
HSD17B4(312-736) [peroxisomal matrix]
(R-HSA-9033495)
0.462
2
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.462
2
UniProt:P26038 MSN
4
MSN [cytosol]
(R-HSA-437350)
MSN(2-448)-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711966)
MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711971)
p-T558-MSN [cytosol]
(R-HSA-9663005)
0.462
3
UniProt:P07996 THBS1
5
THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173263)
glc-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5172997)
O-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173278)
THBS1 [platelet alpha granule lumen]
(R-HSA-114701)
THBS1 [extracellular region]
(R-HSA-66518)
0.462
3
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