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TTN [cytosol]
Stable Identifier
R-HSA-350726
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Titin
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of platelet cytosolic components (Homo sapiens)
Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
M Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
M Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Calcium Binds Troponin-C (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
M Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
M Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
M Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
M Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
M Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
M Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
TTN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WZ42 TTN
Gene Names
TTN
Chain
chain:1-34350
Reference Genes
BioGPS Gene:7273 TTN
COSMIC (genes):TTN TTN
CTD Gene:7273 TTN
dbSNP Gene:7273 TTN
ENSEMBL:ENSG00000155657 TTN
HGNC:12403 TTN
Monarch:7273 TTN
NCBI Gene:7273 TTN
OMIM:188840 TTN
UCSC:Q8WZ42 TTN
Reference Transcript
RefSeq:NM_133379.4 TTN
RefSeq:NM_003319.4 TTN
RefSeq:NM_133432.3 TTN
RefSeq:NM_133378.4 TTN
RefSeq:NM_001256850.1 TTN
Other Identifiers
11715320_s_at
11715339_at
1557994_PM_at
1557994_at
16905600
208195_PM_at
208195_at
241791_PM_at
241791_at
244839_PM_at
244839_at
2589292
2589293
2589295
2589296
2589297
2589299
2589300
2589301
2589303
2589304
2589305
2589306
2589307
2589308
2589309
2589312
2589314
2589315
2589317
2589318
2589319
2589320
2589321
2589322
2589323
2589325
2589326
2589327
2589328
2589329
2589330
2589331
2589332
2589333
2589334
2589335
2589336
2589338
2589339
2589340
2589341
2589342
2589343
2589344
2589345
2589346
2589347
2589348
2589349
2589350
2589351
2589352
2589353
2589354
2589355
2589356
2589357
2589358
2589359
2589360
2589361
2589362
2589363
2589364
2589365
2589366
2589367
2589368
2589369
2589370
2589371
2589372
2589373
2589374
2589375
2589376
2589377
2589378
2589379
2589380
2589381
2589383
2589384
2589386
2589387
2589389
2589390
2589391
2589392
2589394
2589395
2589396
2589398
2589399
2589400
2589401
2589402
2589403
2589404
2589405
2589406
2589407
2589408
2589409
2589410
2589411
2589412
2589413
2589414
2589415
2589416
2589417
2589418
2589419
2589420
2589421
2589422
2589423
2589424
2589428
2589429
2589430
2589431
2589433
2589435
2589436
2589438
2589439
2589441
2589442
2589443
2589444
2589445
2589447
2589449
2589450
2589452
2589453
2589454
2589455
2589456
2589457
2589458
2589459
2589460
2589461
2589462
2589463
2589464
2589465
2589466
2589467
2589468
2589470
2589471
2589472
2589473
2589474
2589475
2589477
2589478
2589479
2589480
2589481
2589482
2589483
2589484
2589485
2589486
2589487
2589488
2589489
2589490
2589491
2589492
2589493
2589494
2589495
2589497
2589498
2589500
2589501
2589502
2589503
2589505
2589506
2589507
2589508
2589509
2589510
2589512
2589513
2589514
2589515
2589516
2589517
2589518
2589519
2589521
2589523
2589524
2589525
2589526
2589527
2589528
2589529
2589530
2589531
2589532
2589534
2589535
2589536
2589537
2589538
2589539
2589541
2589542
2589543
2589545
2589547
2589548
2589549
2589550
2589551
2589553
2589555
2589556
2589557
2589558
2589559
2589561
2589562
2589564
2589565
2589566
2589567
2589568
2589569
2589571
2589573
2589574
2589576
2589577
2589578
2589579
2589581
2589582
2589583
2589584
2589586
2589588
2589589
2589590
2589591
2589592
2589593
2589594
2589595
2589597
2589599
2589600
2589602
2589603
2589604
2589605
2589606
2589607
2589608
2589609
2589610
2589611
2589612
2589613
2589615
2589616
2589617
2589618
2589619
2589620
2589621
2589622
2589624
2589626
2589628
2589630
2589631
2589632
2589633
2589634
2589636
2589638
2589640
2589641
2589642
2589645
2589647
2589649
2589650
2589652
2589654
2589655
2589656
2589657
2589658
2589659
2589661
2589662
2589663
2589664
2589665
2589666
2589667
2589668
2589669
2589670
2589671
2589672
2589673
2589674
2589675
2589676
2589677
2589678
2589680
2589681
2589682
2589683
2589684
2589686
2589687
2589688
2589689
2589691
2589692
2589693
2589694
2589695
2589696
2589697
2589699
2589700
2589701
2589703
2589705
2589707
2589708
2589709
2589710
2589712
2589713
2589714
2589715
2589717
2589718
2589719
2589720
2589721
2589722
2589723
2589724
2589725
2589726
2589727
2589729
2589732
2589733
2589734
2589735
2589736
2589737
2589739
2589740
2589741
2589742
2589743
2589744
2589745
2589746
2589747
2589748
2589750
2589752
2589753
2589754
2589755
2589756
2589757
2589758
2589759
2589760
2589763
2589764
2589765
2589766
2589767
2589768
2589769
2589770
2589771
2589772
2589773
2589774
2589775
2589776
2589777
2589778
2589782
2589783
2589784
2589785
2589786
2589787
2589788
2589789
2589790
2589791
2589792
2589793
2589794
2589795
2589796
2589797
2589799
2589800
2589801
2589802
2589803
2589804
2589805
2589806
2589807
2589808
2589810
2589811
2589812
2589813
2589814
2589815
2589816
2589817
2589818
2589819
2589820
2589821
2589822
2589823
2589824
2589825
2589829
2589831
2589834
2589835
2589836
2589837
2589838
2589840
2589841
2589843
2589844
2589845
2589847
2589849
2589857
2589858
2589859
2589860
40795_at
59544_r_at
7273
78937_at
8057056
A_23_P68219
A_23_P85269
A_33_P3329428
A_33_P3329433
GE60129
GE85677
GE87150
GO:0000228
GO:0000794
GO:0002020
GO:0003012
GO:0003300
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0005198
GO:0005509
GO:0005515
GO:0005516
GO:0005524
GO:0005576
GO:0005634
GO:0005694
GO:0005737
GO:0005829
GO:0005865
GO:0006468
GO:0006936
GO:0006941
GO:0007010
GO:0007076
GO:0008092
GO:0008307
GO:0010628
GO:0010737
GO:0016740
GO:0019887
GO:0019899
GO:0019901
GO:0030016
GO:0030018
GO:0030240
GO:0030241
GO:0031430
GO:0031433
GO:0031674
GO:0035995
GO:0042802
GO:0042803
GO:0042805
GO:0043226
GO:0045214
GO:0046872
GO:0048769
GO:0048856
GO:0050714
GO:0051015
GO:0051371
GO:0051592
GO:0055003
GO:0055008
GO:0055013
GO:0060048
GO:0065003
GO:0070062
GO:0097493
GO:0098772
GO:0106310
GO:0140096
HMNXSV003007721
HMNXSV003011847
Hs.192907.0.A1_3p_at
Hs.283382.0.A1_3p_at
Hs2.421311.1.S1_3p_at
ILMN_1652056
ILMN_1653665
ILMN_1667504
ILMN_1769416
ILMN_2415634
PH_hs_0033344
TC02004724.hg
TC02004725.hg
TC02005047.hg
X90568_at
g4507720_3p_at
Participates
as a component of
M Disk Complex [cytosol] (Homo sapiens)
Z Disk Complex [cytosol] (Homo sapiens)
as a member of
Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
Other forms of this molecule
TTN [extracellular region]
Inferred To
MnM [cytosol]
(Drosophila melanogaster)
Homologues of TTN [cytosol]
(Caenorhabditis elegans)
Homologues of TTN [cytosol]
(Drosophila melanogaster)
igdb-2 [cytosol]
(Caenorhabditis elegans)
TTN [cytosol]
(Caenorhabditis elegans)
TTN [cytosol]
(Drosophila melanogaster)
igdb-1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of TTN [cytosol]
(Bos taurus)
Ghost homologue of TTN [cytosol]
(Canis familiaris)
Ghost homologue of TTN [cytosol]
(Gallus gallus)
Ghost homologue of TTN [cytosol]
(Mus musculus)
Ghost homologue of TTN [cytosol]
(Rattus norvegicus)
PALLD [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
2265
OpenTargets
ENSG00000155657
ENSEMBL
ENSP00000352154
,
ENST00000360870
,
ENSP00000343764
,
ENSP00000354117
,
ENSP00000434586
,
ENST00000591111
,
ENST00000342992
,
ENSP00000465570
,
ENST00000460472
,
ENST00000359218
HPA
ENSG00000155657-TTN
PRO
Q8WZ42
Pharos - Targets
Q8WZ42
Orphanet
TTN
GlyGen
Q8WZ42
HMDB Protein
HMDBP08825
PDB
2A38
,
2F8V
,
8G4L
,
5JDD
,
1BPV
,
2BK8
,
5JDE
,
4UOW
,
1WAA
,
8BVO
,
1TKI
,
2ILL
,
8BNQ
,
2WP3
,
8OSD
,
8OQ9
,
1TIU
,
3B43
,
6FWX
,
3KNB
,
6HCI
,
4JNW
,
6DL4
,
8OMW
,
6I0Y
,
4O00
,
8OIY
,
3PUC
,
1NCT
,
8OVU
,
1TNN
,
2J8O
,
1G1C
,
2WWK
,
8P35
,
4C4K
,
5JDJ
,
3QP3
,
7AHS
,
2RQ8
,
2Y9R
,
8BW6
,
5JOE
,
4QEG
,
2NZI
,
7NIP
,
8OTY
,
1TIT
,
5BS0
,
3LCY
,
3Q5O
,
8OT5
,
1YA5
,
8BXR
,
6YGN
,
8ORL
,
2WWM
,
1NCU
,
2J8H
,
1TNM
,
6SDB
,
3LPW
,
8OS3
,
6H4L
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.59
2
UniProt:Q969Q1 TRIM63
1
TRIM63 [cytosol]
(R-HSA-976020)
0.553
3
UniProt:P52735 VAV2
2
VAV2 [cytosol]
(R-HSA-195012)
p-Y172-VAV2 [cytosol]
(R-HSA-442307)
0.553
2
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.454
2
UniProt:O75923 DYSF
1
DYSF [cytoplasmic vesicle membrane]
(R-HSA-5263626)
0.454
17
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