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CFL1 [extracellular region]
Stable Identifier
R-HSA-350747
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Cofilin-1, COF1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of (inferred) platelet cytosolic components (Homo sapiens)
Platelet releasate (inferred) cytosolic proteins [extracellular region] (Homo sapiens)
CFL1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23528 CFL1
Gene Names
CFL1, Cofilin-1, CFL
Chain
initiator methionine:, chain:2-166
Reference Genes
BioGPS Gene:1072 CFL1
COSMIC (genes):CFL1 CFL1
CTD Gene:1072 CFL1
dbSNP Gene:1072 CFL1
ENSEMBL:ENSG00000172757 CFL1
ENSEMBL_homo_sapiens_GENE:ENSG00000172757.13 CFL1
HGNC:1874 CFL1
KEGG Gene (Homo sapiens):1072 CFL1
Monarch:1072 CFL1
NCBI Gene:1072 CFL1
OMIM:601442 CFL1
Reference Transcript
RefSeq:NM_005507.2 CFL1
Other Identifiers
1072
11753645_a_at
11753646_x_at
11754158_a_at
11757818_x_at
11763259_x_at
1555730_PM_a_at
1555730_a_at
16654211
16654213
16654215
16654217
16654233
16654235
16654237
16654239
16654241
16654243
18671394
18671395
18671397
18671403
18671404
18671405
200021_PM_at
200021_at
33659_at
3377891
3377892
3377893
3377894
3377895
3377897
3377899
3377902
75185_f_at
7892701
7894264
7895149
7895299
7895945
7896038
7949496
GE79937
GO:0000278
GO:0000281
GO:0000910
GO:0003779
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0007010
GO:0007266
GO:0008092
GO:0009615
GO:0012501
GO:0015629
GO:0016020
GO:0016363
GO:0022604
GO:0023052
GO:0030027
GO:0030036
GO:0030042
GO:0030043
GO:0030154
GO:0030424
GO:0030426
GO:0031258
GO:0031982
GO:0032587
GO:0034330
GO:0040019
GO:0042995
GO:0043066
GO:0043226
GO:0044794
GO:0048856
GO:0051014
GO:0051015
GO:0051293
GO:0061001
GO:0070062
HMNXSV003014976
Hs2.180370.2.S1_3p_s_at
ILMN_1705617
TC11001945.hg
X95404_at
g5031634_3p_at
g5031634_3p_x_at
Participates
as a member of
Platelet releasate (inferred) cytosolic proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
CFL1 [cytosol]
p-S3-CFL1 [cytosol]
Cross References
RefSeq
NP_005498.1
OpenTargets
ENSG00000172757
GeneCards
P23528
HPA
ENSG00000172757-CFL1
Ensembl
ENSP00000309629
,
ENSG00000172757
,
ENST00000525451
,
ENST00000308162
,
ENSP00000432660
PRO
P23528
Pharos - Targets
P23528
PDB
6UC4
,
5HVK
,
1Q8G
,
4BEX
,
6UBY
,
1Q8X
,
6VAO
,
5L6W
,
3J0S
,
6UC0
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB [nucleoplasm]
(R-HSA-3321990)
ACTB [cytosol]
(R-HSA-201861)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [plasma membrane]
(R-HSA-196016)
0.933
11
UniProt:P63261 ACTG1
3
ACTG1 [cytosol]
(R-HSA-201858)
ACTG1 [lysosomal membrane]
(R-HSA-196169)
ACTG1 [plasma membrane]
(R-HSA-196044)
0.831
10
UniProt:P53667 LIMK1
3
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
LIMK1 [cytosol]
(R-HSA-397785)
0.722
3
UniProt:P54253 ATX1
0.703
11
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.668
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.656
3
UniProt:P40123 CAP2
1
CAP2 [cytosol]
(R-HSA-428863)
0.643
4
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.577
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.577
3
UniProt:Q13393 PLD1
4
PLD1 [endoplasmic reticulum membrane]
(R-HSA-1498795)
PLD1 [plasma membrane]
(R-HSA-2028998)
PLD1 [tertiary granule membrane]
(R-HSA-6800955)
PLD1 [specific granule membrane]
(R-HSA-6799531)
0.571
4
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
10
UniProt:P68032 ACTC1
1
ACTC1 [cytosol]
(R-HSA-390536)
0.564
2
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.556
3
UniProt:Q549N0 Q549N0
0.556
3
UniProt:Q1KLZ0 Q1KLZ0
0.556
3
UniProt:Q15303 ERBB4
0.553
2
UniProt:Q9Y281 COF2
0.547
3
UniProt:O14939 PLD2
2
PLD2 [plasma membrane]
(R-HSA-2029075)
PLD2 [endoplasmic reticulum membrane]
(R-HSA-1498791)
0.544
2
UniProt:P57058 HUNK
0.524
2
UniProt:P0DOE7 M
5
p-S95,T205-M [cytosol]
(R-RSY-9831678)
p-S95,T205-M [nucleoplasm]
(R-RSY-9831706)
M [nucleoplasm]
(R-RSY-9831711)
Nascent M [cytosol]
(R-RSY-9828672)
p-S95,T205-M [viral tegument]
(R-RSY-9836531)
0.524
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
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