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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
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Developer's Zone
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Pathway Diagrams
Icon Info
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Curator Guide
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FAQ
Linking to Us
Citing us
Tools
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Analyse gene list
Analyse gene expression
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VCL [cytosol]
Stable Identifier
R-HSA-350753
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Vinculin
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Release of platelet cytosolic components (Homo sapiens)
Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
VCL [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18206 VCL
Gene Names
VCL
Chain
chain:1-1134
Reference Genes
COSMIC (genes):VCL VCL
dbSNP Gene:7414 VCL
ENSEMBL:ENSG00000035403 VCL
Participates
as a component of
integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
Vinculin bound to PIP2 [plasma membrane] (Homo sapiens)
as a member of
Platelet releasate cytosolic proteins [cytosol] (Homo sapiens)
as an input of
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Homo sapiens)
Other forms of this molecule
VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol]
VCL(1-811)-ALK(1058-1620) fusion [cytosol]
VCL(95 kDa) [cytosol]
VCL [ficolin-1-rich granule lumen]
VCL [secretory granule lumen]
VCL [extracellular region]
VCL [specific granule lumen]
Inferred To
Vinc [cytosol]
(Drosophila melanogaster)
fip-2 [cytosol]
(Dictyostelium discoideum)
deb-1 [cytosol]
(Caenorhabditis elegans)
Vcl [cytosol]
(Mus musculus)
Vcl [cytosol]
(Rattus norvegicus)
vcla [cytosol]
(Danio rerio)
VCL [cytosol]
(Bos taurus)
VCL [cytosol]
(Canis familiaris)
VCL [cytosol]
(Gallus gallus)
VCL [cytosol]
(Sus scrofa)
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18010 IPAA
0.758
7
UniProt:Q6XVZ2 Q6XVZ2
0.719
4
UniProt:B0BXR4 B0BXR4
0.65
6
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
9
UniProt:Q62417-2 SORBS1
0.591
3
UniProt:Q969V4 TEKT1
0.556
3
UniProt:Q9NYB9 ABI2
2
p-4S-ABI2 [cytosol]
(R-HSA-2029003)
ABI2 [cytosol]
(R-HSA-1671647)
0.553
3
UniProt:Q15654 TRIP6
0.553
2
UniProt:P35221 CTNNA1
2
CTNNA1 [plasma membrane]
(R-HSA-191735)
CTNNA1 [cytosol]
(R-HSA-191697)
0.527
2
UniProt:Q9Y490 TLN1
4
TLN1 [extracellular region]
(R-HSA-350693)
TLN1(434-2541) [cytosol]
(R-HSA-9855156)
TLN1(1-433) [cytosol]
(R-HSA-9855031)
TLN1 [cytosol]
(R-HSA-350713)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P62979 RPS27A
20
RPS27A(1-76) [endocytic vesicle membrane]
(R-HSA-939208)
RPS27A(77-156) [nucleoplasm]
(R-HSA-6798734)
Ub-33-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783024)
Ub-63-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783200)
Ub-6-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783040)
Ub-11-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783085)
Ub-48-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783075)
Ub-29-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-6783146)
Ub-63-RPS27A(1-76) [cytosol]
(R-HSA-939248)
RPS27A(1-76) [lysosomal lumen]
(R-HSA-9660001)
RPS27A(1-76) [cytosol]
(R-HSA-939205)
p-S65-RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-9834951)
Ub-48-RPS27A(1-76) [cytosol]
(R-HSA-939202)
RPS27A(1-76) [mitochondrial outer membrane]
(R-HSA-9834993)
RPS27A(1-76) [late endosome lumen]
(R-HSA-9660022)
Ub-6-RPS27A(1-76) [nucleoplasm]
(R-HSA-6782608)
Ub-63-RPS27A(1-76) [nucleoplasm]
(R-HSA-6782503)
Ub-48-RPS27A(1-76) [nucleoplasm]
(R-HSA-5683037)
RPS27A(1-76) [nucleoplasm]
(R-HSA-939849)
Ub-11-RPS27A(1-76) [cytosol]
(R-HSA-3095933)
0.527
2
UniProt:Q7Z4L5 TTC21B
2
TTC21B [ciliary tip]
(R-HSA-5625349)
TTC21B [cilium]
(R-HSA-5610430)
0.508
2
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