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Regulation of thyroid hormone activity
Stable Identifier
R-HSA-350864
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Thyroxine biosynthesis (Homo sapiens)
Regulation of thyroid hormone activity (Homo sapiens)
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The iodothyronine deiodinases (DIO) are dimeric, membrane-bound enzymes that regulate the activity of thyroid hormone by removal of specific iodines from the precursor T4. There are three types of DIOs in humans; types I, II and III (D1, D2 and D3 respectively) which are proteins of about 250 residues that contain a selenocysteine at their active site. Signaling by thyroid hormone can change in individual tissues by this activation or inactivation process, even when serum concentrations of the hormone remain normal. Generally, cell types express just one type of DIO at any one time. The exception is the pituitary gland which expresses all three.
Literature References
PubMed ID
Title
Journal
Year
17016550
Deiodinases: implications of the local control of thyroid hormone action
Bianco, AC
,
Kim, BW
J Clin Invest
2006
Participants
Events
Thyroxine is deiodinated to triiodothyronine
(Homo sapiens)
Thyroxine is deiodinated to reverse triiodothyronine (RT3)
(Homo sapiens)
Participates
as an event of
Thyroxine biosynthesis (Homo sapiens)
Event Information
Go Biological Process
thyroid hormone metabolic process (0042403)
Orthologous Events
Regulation of thyroid hormone activity (Bos taurus)
Regulation of thyroid hormone activity (Canis familiaris)
Regulation of thyroid hormone activity (Dictyostelium discoideum)
Regulation of thyroid hormone activity (Gallus gallus)
Regulation of thyroid hormone activity (Mus musculus)
Regulation of thyroid hormone activity (Rattus norvegicus)
Regulation of thyroid hormone activity (Sus scrofa)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2008-05-28)
Created
Jassal, B (2008-05-21)
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