Iodide is organified

Stable Identifier
R-HSA-350901
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Iodide is organified
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The first step in the biogenesis of thyroid hormones is the oxidation of iodide (I-) by H2O2/peroxidase after being taken up by the thyroid gland. This event is known as organification.
Literature References
PubMed ID Title Journal Year
1722671 Formation of molecular iodine during oxidation of iodide by the peroxidase/H2O2 system. Implications for antithyroid therapy

Buxeraud, J, Raby, M, Thomes, JC, Raby, C, Lagorce, JF, Catanzano, G

Biochem Pharmacol 1991
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peroxidase activity of TPO [plasma membrane]

Physical Entity
TPO [plasma membrane] (Homo sapiens)
Activity
peroxidase activity (GO:0004601)
Orthologous Events
Iodide is organified (Bos taurus)
Iodide is organified (Caenorhabditis elegans)
Iodide is organified (Canis familiaris)
Iodide is organified (Dictyostelium discoideum)
Iodide is organified (Drosophila melanogaster)
Iodide is organified (Gallus gallus)
Iodide is organified (Mus musculus)
Iodide is organified (Rattus norvegicus)
Iodide is organified (Sus scrofa)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-05-21)
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