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DAAM1 [cytosol]
Stable Identifier
R-HSA-351052
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Daam1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
DAAM1 recruits GTP-bound RHOA (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
ppDVL:DAAM1:RHOA:GTP [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
ppDVL binds DAAM1 (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB binds effectors at the plasma membrane (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC binds effectors at the plasma membrane (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
RHOC:GTP:RHOC effectors [plasma membrane] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
DAAM1 recruits GTP-bound RHOA (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
ppDVL:DAAM1:RHOA:GTP [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
DAAM1 recruits PFN1 (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
ppDVL:DAAM1:PFN1 [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
ppDVL binds DAAM1 (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
DAAM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4D1 DAAM1
Gene Names
DAAM1, KIAA0666
Chain
chain:1-1078
Reference Genes
BioGPS Gene:23002 DAAM1
COSMIC (genes):DAAM1 DAAM1
CTD Gene:23002 DAAM1
dbSNP Gene:23002 DAAM1
ENSEMBL:ENSG00000100592 DAAM1
HGNC:18142 DAAM1
KEGG:hsa:23002 DAAM1
Monarch:23002 DAAM1
NCBI Gene:23002 DAAM1
OMIM:606626 DAAM1
UCSC:Q9Y4D1 DAAM1
Reference Transcript
RefSeq:NM_001270520.2 DAAM1
RefSeq:XM_005267430.3 DAAM1
RefSeq:XM_054375646.1 DAAM1
RefSeq:XM_005267431.2 DAAM1
RefSeq:XM_054375648.1 DAAM1
RefSeq:NM_014992.2 DAAM1
RefSeq:XM_054375647.1 DAAM1
RefSeq:XM_047431135.1 DAAM1
Participates
as a component of
Fz1:Dvl2:Daam1:RhoA:GTP [plasma membrane] (Homo sapiens)
Fz1:Dvl2:Daam1 [plasma membrane] (Homo sapiens)
ppDVL:DAAM1 [cytosol] (Homo sapiens)
as an input of
Dvl2 binds to Daam1 (Homo sapiens)
ppDVL binds DAAM1 (Homo sapiens)
as a member of
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
RHOC effectors [cytosol] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
as a candidate of
CDC42 effectors [cytosol] (Homo sapiens)
Inferred To
forD [cytosol]
(Dictyostelium discoideum)
forF [cytosol]
(Dictyostelium discoideum)
Homologues of DAAM1 [cytosol]
(Dictyostelium discoideum)
Daam1 [cytosol]
(Mus musculus)
Daam1 [cytosol]
(Rattus norvegicus)
forE [cytosol]
(Dictyostelium discoideum)
forH [cytosol]
(Dictyostelium discoideum)
forA [cytosol]
(Dictyostelium discoideum)
daam1b [cytosol]
(Danio rerio)
daam-1 [cytosol]
(Caenorhabditis elegans)
daam1 [cytosol]
(Xenopus tropicalis)
DAAM [cytosol]
(Drosophila melanogaster)
forB [cytosol]
(Dictyostelium discoideum)
DAAM1 [cytosol]
(Bos taurus)
DAAM1 [cytosol]
(Canis familiaris)
DAAM1 [cytosol]
(Gallus gallus)
DAAM1 [cytosol]
(Plasmodium falciparum)
DAAM1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_005267488.1
,
XP_054231623.1
,
XP_054231622.1
,
NP_055807.1
,
XP_005267487.1
,
XP_047287091.1
,
XP_054231621.1
,
NP_001257449.1
OpenTargets
ENSG00000100592
ENSEMBL
ENSP00000378557
,
ENSG00000100592
,
ENST00000395125
,
ENSP00000354162
,
ENST00000360909
HPA
ENSG00000100592-DAAM1
GeneCards
DAAM1
PRO
Q9Y4D1
Pharos - Targets
Q9Y4D1
GlyGen
Q9Y4D1
PDB
2J1D
,
2Z6E
HMDB Protein
HMDBP08342
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61586 RHOA
6
RHOA [plasma membrane]
(R-HSA-194510)
RHOA [cell junction]
(R-HSA-2134503)
RHOA [cytosol]
(R-HSA-194866)
RHOA [secretory granule membrane]
(R-HSA-6804980)
RHOA [ficolin-1-rich granule membrane]
(R-HSA-6804971)
RHOA [endoplasmic reticulum membrane]
(R-HSA-5672082)
0.87
11
UniProt:O00212 RHOD
5
RHOD [mitochondrial outer membrane]
(R-HSA-9693212)
RHOD [cytosol]
(R-HSA-194848)
RHOD [plasma membrane]
(R-HSA-194889)
RHOD [Golgi membrane]
(R-HSA-9693236)
RHOD [endosome membrane]
(R-HSA-5666090)
0.688
4
UniProt:P08134 RHOC
3
RHOC [plasma membrane]
(R-HSA-194870)
RHOC [cytosol]
(R-HSA-194853)
RHOC [endoplasmic reticulum membrane]
(R-HSA-9714362)
0.688
4
UniProt:Q9Y4D1 DAAM1
1
DAAM1 [cytosol]
(R-HSA-351052)
0.609
2
UniProt:P00523 SRC
9
SRC [cytosol]
(R-GGA-191648)
phospho-SRC [plasma membrane]
(R-GGA-1810408)
SRC [plasma membrane]
(R-GGA-65043)
phospho-SRC [plasma membrane]
(R-GGA-377598)
phospho-SRC [cytosol]
(R-GGA-377592)
Src [cytosol]
(R-GGA-3928468)
SRC [plasma membrane]
(R-GGA-8876922)
SRC [cytosol]
(R-GGA-9628701)
phospho-SRC [cytosol]
(R-GGA-8964276)
0.556
3
UniProt:Q9H425 CA198
0.527
3
UniProt:Q8NCC5 SPX3
0.527
2
UniProt:Q8N461 FBXL16
1
FBXL16 [cytosol]
(R-HSA-8862609)
0.527
3
UniProt:Q5T0N5 FNBP1L
1
FNBP1L [cytosol]
(R-HSA-8867730)
0.524
2
UniProt:Q15642-2 TRIP10
0.524
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
9
UniProt:O14640 DVL1
4
DVL1 [cytosol]
(R-HSA-201687)
ub-DVL1 [cytosol]
(R-HSA-4641157)
pp-DVL1 [cytosol]
(R-HSA-3772396)
p-S-DVL1 [cytosol]
(R-HSA-201700)
0.463
2
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