Agmatine biosynthesis

Stable Identifier
R-HSA-351143
Type
Pathway
Species
Homo sapiens
Compartment
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Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine. Agmatine binds to several target receptors in the brain and has been proposed as a novel neuromodulator (Reghunathan 2006). Agmatine has the potential to serve in the coordination of the early and repair phase pathways of arginine in inflammation (Satriano, 2003).

Literature References
PubMed ID Title Journal Year
15028568 Agmatine: at the crossroads of the arginine pathways

Satriano, J

Ann N Y Acad Sci 2003
15028567 Vertebrate agmatinases: what role do they play in agmatine catabolism?

Morris SM, Jr

Ann N Y Acad Sci 2003
15784477 Polyamines: metabolism and implications in human diseases

Moinard, C, Cynober, L, de Bandt, JP

Clin Nutr 2005
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Orthologous Events
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