Reactome | Agmatine biosynthesis

Agmatine biosynthesis

Stable Identifier

R-HSA-351143

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine. Agmatine binds to several target receptors in the brain and has been proposed as a novel neuromodulator (Reghunathan 2006). Agmatine has the potential to serve in the coordination of the early and repair phase pathways of arginine in inflammation (Satriano, 2003).

Literature References

PubMed ID	Title	Journal	Year
15028567	Vertebrate agmatinases: what role do they play in agmatine catabolism? Morris SM, Jr	Ann N Y Acad Sci	2003
15028568	Agmatine: at the crossroads of the arginine pathways Satriano, J	Ann N Y Acad Sci	2003
15784477	Polyamines: metabolism and implications in human diseases de Bandt, JP, Cynober, L, Moinard, C	Clin Nutr	2005