Reactome | AP1B1 [cytoplasmic vesicle membrane]

AP1B1 [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-351181

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

AP-1 beta subunit

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q10567 AP1B1

Gene Names

AP1B1, ADTB1, BAM22, CLAPB2

Chain

chain:1-949

Reference Genes

COSMIC (genes):AP1B1 AP1B1

dbSNP Gene:162 AP1B1

ENSEMBL:ENSG00000100280 AP1B1

Participates

as a component of

AP-1 Complex [cytoplasmic vesicle membrane] (Homo sapiens)

Other forms of this molecule

AP1B1 [Golgi membrane]

AP1B1 [lysosomal membrane]

AP1B1 [trans-Golgi network membrane]

AP1B1 [cytosol]

Inferred To

AP1B1 [cytoplasmic vesicle membrane] (Bos taurus)

AP1B1 [cytoplasmic vesicle membrane] (Canis familiaris)

AP1B1 [cytoplasmic vesicle membrane] (Gallus gallus)

AP1B1 [cytoplasmic vesicle membrane] (Sus scrofa)

Ap1b1 [cytoplasmic vesicle membrane] (Mus musculus)

Ap1b1 [cytoplasmic vesicle membrane] (Rattus norvegicus)

APL2 [cytoplasmic vesicle membrane] (Saccharomyces cerevisiae)

apb-1 [cytoplasmic vesicle membrane] (Caenorhabditis elegans)

AP-1-2beta [cytoplasmic vesicle membrane] (Drosophila melanogaster)

ap1b1 [cytoplasmic vesicle membrane] (Dictyostelium discoideum)

ap1b1 [cytoplasmic vesicle membrane] (Xenopus tropicalis)

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.649	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	13
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.527	4
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.527	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4