Interconversion of polyamines

Stable Identifier
R-HSA-351200
Type
Pathway
Species
Homo sapiens
Compartment
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The reactions catalyzed by aminopropyl-transferases annotated above are generally irreversible. But spermine and spermidine can be recycled respectively into spermidine and putrescine. These events require the formation of N-acetylated intermediates, N1-acetylspermine and N1-acetylspermidine catalyzed by a cytosolic acetyl-CoA:spermidine/spermine N1-acetyl-tranferase (SSAT) enzyme.
Subsequently, polyamine-oxidase (PAO), a FAD enzyme present in the peroxysomes, yields a polyamine with release of an aldehyde (3-acetamindopropanal) and H2O2.
In addition, SMOX, a FAD-dependent, polyamine oxidase (PAOh1/SMO) that can efficiently use spermine as a substrate and is involved in interconversion reactions.

Literature References
PubMed ID Title Journal Year
15221502 Catabolism of polyamines

Seiler, N

Amino Acids 2004
11564948 Polyamine metabolism revisited

Urdiales, JL, Medina, MA, Sánchez-Jiménez, F

Eur J Gastroenterol Hepatol 2001
12686127 Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide

Hillary, RA, Pegg, AE

Biochim Biophys Acta 2003
15784477 Polyamines: metabolism and implications in human diseases

Moinard, C, Cynober, L, de Bandt, JP

Clin Nutr 2005
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Orthologous Events
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