Metabolism of polyamines

Stable Identifier
R-HSA-351202
DOI
Type
Pathway
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure:
Literature References
PubMed ID Title Journal Year
11564948 Polyamine metabolism revisited

Medina, MA, Urdiales, JL, Sánchez-Jiménez, F

Eur J Gastroenterol Hepatol 2001
12686127 Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide

Hillary, RA, Pegg, AE

Biochim Biophys Acta 2003
15784477 Polyamines: metabolism and implications in human diseases

de Bandt, JP, Cynober, L, Moinard, C

Clin Nutr 2005
Participants
Participates
Event Information
Orthologous Events
Authored
Reviewed
Created
Cite Us!