Reactome | Metabolism of polyamines

Metabolism of polyamines

Stable Identifier

R-HSA-351202

DOI

10.3180/REACT_14820.1

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, peroxisomal matrix

ReviewStatus

5/5

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Polyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that arginine can be metabolised according to the same pathway leading to agmatine formation. Polyamines are essential for the growth, the maintenance and the function of normal cells. The complexity of their metabolism and the fact that polyamines homeostasis is tightly regulated support the idea that polyamines are essential to cell survival. Multiple abnormalities in the control of polyamines metabolism might be implicated in several pathological processes (Moinard et al., 2005). Legend for the following figure:

Literature References

PubMed ID	Title	Journal	Year
11564948	Polyamine metabolism revisited Medina, MA, Urdiales, JL, Sánchez-Jiménez, F	Eur J Gastroenterol Hepatol	2001
12686127	Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide Hillary, RA, Pegg, AE	Biochim Biophys Acta	2003
15784477	Polyamines: metabolism and implications in human diseases de Bandt, JP, Cynober, L, Moinard, C	Clin Nutr	2005