Reactome | Metabolism of polyamines

Metabolism of polyamines

Stable Identifier

R-HSA-351202

DOI

10.3180/REACT_14820.1

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, peroxisomal matrix

ReviewStatus

5/5

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Three polyamines - putrescine, spermine, and spermidine - are derived from ornithine by decarboxylation and condensation reactions. Arginine is metabolised similarly to form a fourth polyamine, agmatine. Polyamine levels are tightly regulated at the level of the enzyme ornithine decarboxylase (ODC) (Hillary and Pegg 2003; Moinard et al. 2005; Urdiales et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
15784477	Polyamines: metabolism and implications in human diseases Moinard, C, Cynober, L, de Bandt, JP	Clin Nutr	2005
12686127	Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide Hillary, RA, Pegg, AE	Biochim Biophys Acta	2003
11564948	Polyamine metabolism revisited Urdiales, JL, Medina, MA, Sánchez-Jiménez, F	Eur J Gastroenterol Hepatol	2001