Spermidine => N-acetylated spermidine

Stable Identifier
R-HSA-351208
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines. Defects in SAT1 may be the cause of keratosis follicularis spinulosa decalvans (KFSD).

Literature References
PubMed ID Title Journal Year
1985966 Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase

Casero RA, Jr, Celano, P, Ervin, SJ, Applegren, NB, Wiest, L, Pegg, AE

J Biol Chem 1991
8360194 Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells

Fogel-Petrovic, M, Shappell, NW, Bergeron, RJ, Porter, CW

J Biol Chem 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
diamine N-acetyltransferase activity of SAT1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed