Reactome | dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

Stable Identifier

R-HSA-351210

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine

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The protein encoded by this gene belongs to the spermidine/spermine synthases family. This gene encodes an ubiquitous enzyme of polyamine metabolism. Defects in SMS are the cause of Snyder-Robinson syndrome (SRS).

Literature References

PubMed ID	Title	Journal	Year
7546290	Molecular cloning of a cDNA encoding human spermine synthase Keinänen, T, Korhonen, VP, Halmekytö, M, Alhonen, L, Myöhänen, S, Eloranta, T, Wahlfors, J, Kauppinen, L, Jänne, J, Hyvönen, T	DNA Cell Biol	1995