Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine

Stable Identifier
R-HSA-351215
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.

Literature References
PubMed ID Title Journal Year
2069720 Human spermidine synthase gene: structure and chromosomal localization

Myöhänen, S, Kauppinen, L, Wahlfors, J, Alhonen, L, Jänne, J

DNA Cell Biol 1991
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
spermidine synthase activity of SRM [cytosol]
Physical Entity
SRM [cytosol]
Activity
spermidine synthase activity (0004766)
Orthologous Events
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Bos taurus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Caenorhabditis elegans)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Canis familiaris)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Danio rerio)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Dictyostelium discoideum)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Drosophila melanogaster)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Gallus gallus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Mus musculus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Plasmodium falciparum)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Rattus norvegicus)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Saccharomyces cerevisiae)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Schizosaccharomyces pombe)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Sus scrofa)
Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine (Xenopus tropicalis)
Cross References
Target Pathogen
Rhea
Authored
Gopinathrao, G  (2008-05-21)
Reviewed
D'Eustachio, P  (2008-06-12)
Cite Us!