Reactome | TBL1XR1 [nucleoplasm]

TBL1XR1 [nucleoplasm]

Stable Identifier

R-HSA-351643

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TBL1R_HUMAN, F-box-like/WD repeat-containing protein, TBL1R

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Notch-HLH transcription pathway (Homo sapiens)
      - Formation of CSL NCOR corepressor complex (Homo sapiens)
        
        RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
        
        TBL1 [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 [nucleoplasm] (Homo sapiens)
        
        TBL1 [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 [nucleoplasm] (Homo sapiens)
    - Transcriptional Regulation by MECP2 (Homo sapiens)
      - Regulation of MECP2 expression and activity (Homo sapiens)
        
        MECP2 binds the NCoR/SMRT complex (Homo sapiens)
        
        MECP2:NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCOR1 complex [nucleoplasm] (Homo sapiens)
        
        TBL1X tetramer, TBL1XR1 tetramer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 tetramer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 dimer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 [nucleoplasm] (Homo sapiens)
        
        NCOR2 complex [nucleoplasm] (Homo sapiens)
        
        TBL1X tetramer, TBL1XR1 tetramer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 tetramer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 dimer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 [nucleoplasm] (Homo sapiens)
        
        NCoR/SMRT complex [nucleoplasm] (Homo sapiens)
        
        NCOR1 complex [nucleoplasm] (Homo sapiens)
        
        TBL1X tetramer, TBL1XR1 tetramer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 tetramer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 dimer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 [nucleoplasm] (Homo sapiens)
        
        NCOR2 complex [nucleoplasm] (Homo sapiens)
        
        TBL1X tetramer, TBL1XR1 tetramer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 tetramer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 dimer [nucleoplasm] (Homo sapiens)
        
        TBL1XR1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BZK7 TBL1XR1

Gene Names

TBL1XR1, IRA1, TBLR1

Chain

initiator methionine:1, chain:2-514

Reference Genes

BioGPS Gene:79718 TBL1XR1

COSMIC (genes):TBL1XR1 TBL1XR1

CTD Gene:79718 TBL1XR1

dbSNP Gene:79718 TBL1XR1

ENSEMBL:ENSG00000177565 TBL1XR1

HGNC:29529 TBL1XR1

KEGG Gene (Homo sapiens):79718 TBL1XR1

Monarch:79718 TBL1XR1

NCBI Gene:79718 TBL1XR1

OMIM:608628 TBL1XR1

UCSC:Q9BZK7 TBL1XR1

Reference Transcript

Other Identifiers

0001940204

11716781_s_at

11716782_a_at

11716783_a_at

11749744_a_at

16961704

221428_s_at

222633_at

222634_s_at

223013_at

235890_at

2706314

2706315

2706316

2706317

2706318

2706319

2706320

2706321

2706322

2706323

2706324

2706325

2706326

2706327

2706330

2706334

2706335

2706337

2706338

2706341

2706342

2706343

2706344

2706345

2706346

2706347

2706351

2706352

2706359

2706399

2706400

2706401

2973323

2973324

45115_at

46257_at

51654_at

79718

8092201

87125_at

88304_at

91118_at

A_23_P212552

A_23_P212554

A_23_P57989

A_24_P114604

A_24_P128880

A_33_P3348614

GE82896

GE86826

GE87627

GO:0000118

GO:0000122

GO:0000976

GO:0001835

GO:0002021

GO:0003674

GO:0003677

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005856

GO:0006325

GO:0006357

GO:0006464

GO:0006629

GO:0007165

GO:0007267

GO:0008013

GO:0008150

GO:0009056

GO:0009058

GO:0009790

GO:0010468

GO:0016042

GO:0016575

GO:0017053

GO:0019216

GO:0030154

GO:0032991

GO:0034641

GO:0035264

GO:0040007

GO:0042393

GO:0043161

GO:0043226

GO:0045892

GO:0045893

GO:0045944

GO:0047485

GO:0048856

GO:0050872

GO:0051276

GO:0060612

GO:0060613

GO:0072686

GO:0090207

GO:0090263

Hs.31903.0.A1_3p_at

ILMN_1798657

PH_hs_0002711

PH_hs_0025713

PH_hs_0033440

TC03002022.hg

g12006054_3p_at

g12006103_3p_at

g12642595_3p_a_at

g13569880_3p_s_at

Participant Of

hasComponent

hasMember

TBL1 [nucleoplasm]

input

PPARA:RXRA heterodimer recruits corepressors

Inferred To

ebi [nucleoplasm] (Drosophila melanogaster)

tbl1xr1a [nucleoplasm] (Danio rerio)

SIF2 [nucleoplasm] (Saccharomyces cerevisiae)

TBL1XR1 [nucleoplasm] (Bos taurus)

TBL1XR1 [nucleoplasm] (Canis familiaris)

TBL1XR1 [nucleoplasm] (Gallus gallus)

TBL1XR1 [nucleoplasm] (Sus scrofa)

Tbl1xr1 [nucleoplasm] (Mus musculus)

Tbl1xr1 [nucleoplasm] (Rattus norvegicus)

tbl1xr1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

XP_011511443.1, NP_078941.2, XP_011511444.1, NP_001308123.1, XP_011511445.1, XP_016862674.1, NP_001308124.1, XP_005247832.1, NP_001308122.1, XP_006713809.1

OpenTargets

ENSG00000177565

GeneCards

Q9BZK7

HPA

ENSG00000177565-TBL1XR1

Ensembl

ENSG00000177565, ENST00000457928, ENSP00000413251, ENST00000430069, ENSP00000405574

PRO

Q9BZK7

Orphanet

22998

PDB

4LG9

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.696	6
UniProt:P36404 ARL2	2	ARL2 [cytosol] (R-HSA-5216230) ARL2 [mitochondrial matrix] (R-HSA-5250216)	0.666	4
UniProt:P00441 SOD1	5	2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [extracellular region] (R-HSA-350705) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:O15379 HDAC3	2	Unfolded HDAC3 [cytosol] (R-HSA-6813777) HDAC3 [nucleoplasm] (R-HSA-442464)	0.527	3
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.527	2
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.462	2

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