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SIN3A [nucleoplasm]
Stable Identifier
R-HSA-351657
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SIN3A_HUMAN, Paired amphipathic helix protein Sin3a
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
Fatty acid ligands activate PPARA (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PPARA:RXRA:Corepressors [nucleoplasm] (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in apoptosis (Homo sapiens)
HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Homo sapiens)
HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MITF-M-dependent BCL2 expression (Homo sapiens)
HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (Homo sapiens)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Homo sapiens)
HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 binds the CCND1 gene (Homo sapiens)
HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Disorders of Developmental Biology (Homo sapiens)
Disorders of Nervous System Development (Homo sapiens)
Pervasive developmental disorders (Homo sapiens)
Loss of function of MECP2 in Rett syndrome (Homo sapiens)
Loss of MECP2 binding ability to 5mC-DNA (Homo sapiens)
MECP2 T158A:SIN3A complex does not bind BDNF gene promoter (Homo sapiens)
MECP2 T158A:SIN3A:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
NoRC negatively regulates rRNA expression (Homo sapiens)
NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
SIN3 HDAC corepressor complex [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
SIN3 HDAC corepressor complex [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
SIN3 HDAC corepressor complex [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3 HDAC corepressor complex [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO1 and SIN3A:HDAC complex bind GCK gene promoter (Homo sapiens)
FOXO1:SIN3A:HDAC1.HDAC2 dimers:GCK gene [nucleoplasm] (Homo sapiens)
FOXO1:SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC2 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC2 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
GCK gene expression is inhibited by FOXO1, SIN3A and HDACs (Homo sapiens)
FOXO1:SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC2 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
FOXO1:SIN3A:HDAC1.HDAC2 dimers:GCK gene [nucleoplasm] (Homo sapiens)
FOXO1:SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC2 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates neuronal receptors and channels (Homo sapiens)
GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2:GRIA2 gene [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A complex binds GRIA2 gene promoter (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2:GRIA2 gene [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A complex binds OPRM1 gene promoter (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC1:OPRM1 gene [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
OPRM1 gene expression is repressed by MECP2 (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC1:OPRM1 gene [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2 regulates transcription of neuronal ligands (Homo sapiens)
BDNF gene transcription (Homo sapiens)
MECP2:SIN3A:HDAC1:BDNF gene [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A complex binds the promoter of the BDNF gene (Homo sapiens)
MECP2:SIN3A:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:BDNF gene [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Regulation of MECP2 expression and activity (Homo sapiens)
MECP2 binds the SIN3A co-repressor complex (Homo sapiens)
MECP2:SIN3A:HDAC1,HDAC2 [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MECP2:SIN3A:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A:HDAC2 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1,HDAC2 dimers [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:HDAC2 homodimer [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
p53, SIN3A and MYB form a complex (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
p53:MYB:SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
Fatty acid ligands activate PPARA (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PPARA:RXRA:Corepressors [nucleoplasm] (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PPARA binds fibrates (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PPARA:RXRA:Corepressors [nucleoplasm] (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PPARA:RXRA binds Corepressors of PPARA (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PPARA:RXRA:Corepressors [nucleoplasm] (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 nuclear events downstream of ALK signaling (Homo sapiens)
AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm] (Homo sapiens)
AcK685-p-Y705,S727 STAT3 dimer:SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:AcK685,p-Y705,p-S727 STAT3 dimer:PRDM1 gene [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
IL2RG gene expression downstream of ALK signaling (Homo sapiens)
AcK685-p-Y705,S727 STAT3 dimer:SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm] (Homo sapiens)
AcK685-p-Y705,S727 STAT3 dimer:SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
PRDM1 gene expression downstream of ALK signaling (Homo sapiens)
AcK685-p-Y705,S727 STAT3 dimer:SIN3A [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:AcK685,p-Y705,p-S727 STAT3 dimer:PRDM1 gene [nucleoplasm] (Homo sapiens)
SIN3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96ST3 SIN3A
Gene Names
SIN3A
Chain
chain:1-1273
Reference Genes
BioGPS Gene:25942 SIN3A
COSMIC (genes):SIN3A SIN3A
CTD Gene:25942 SIN3A
dbSNP Gene:25942 SIN3A
ENSEMBL:ENSG00000169375 SIN3A
ENSEMBL_homo_sapiens_GENE:ENSG00000169375.17 SIN3A
HGNC:19353 SIN3A
KEGG Gene (Homo sapiens):25942 SIN3A
Monarch:25942 SIN3A
NCBI Gene:25942 SIN3A
OMIM:607776 SIN3A
UCSC:Q96ST3 SIN3A
Reference Transcript
RefSeq:XM_006720465.3 SIN3A
RefSeq:XM_006720466.3 SIN3A
RefSeq:XM_006720467.3 SIN3A
RefSeq:NM_001145357.1 SIN3A
RefSeq:NM_001145358.1 SIN3A
RefSeq:NM_015477.2 SIN3A
Other Identifiers
11730293_a_at
11730294_a_at
11735494_a_at
16811791
17121228
225135_PM_at
225135_at
238005_PM_s_at
238005_s_at
238006_PM_at
238006_at
25942
3633311
3633397
3633398
3633399
3633400
3633401
3633402
3633404
3633405
3633406
3633407
3633408
3633411
3633413
3633415
3633417
3633418
3633419
3633422
3633425
3633426
3633427
3633429
3633430
3633431
3633432
3633433
3633434
3633435
3633436
3633437
3633438
3633445
3633446
3633448
3633450
3633451
3633452
3633459
3638857
43176_at
49525_i_at
49527_r_at
7990487
82996_at
A_23_P367676
A_24_P304760
GE56490
GO:0000118
GO:0000122
GO:0000228
GO:0000278
GO:0000776
GO:0000785
GO:0001701
GO:0002218
GO:0002230
GO:0002244
GO:0002376
GO:0003677
GO:0003682
GO:0003714
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0006260
GO:0006325
GO:0006351
GO:0006355
GO:0008104
GO:0010243
GO:0010817
GO:0010971
GO:0012501
GO:0017053
GO:0021895
GO:0023052
GO:0030154
GO:0030336
GO:0030512
GO:0030516
GO:0031507
GO:0032991
GO:0042754
GO:0043066
GO:0043226
GO:0044877
GO:0045666
GO:0045892
GO:0048511
GO:0048856
GO:0048870
GO:0051595
GO:0060337
GO:0061629
GO:0070822
GO:0071333
GO:0072736
GO:0098542
GO:0098772
GO:0140110
GO:0140416
GO:1900181
GO:1902455
GO:1902459
GO:1903351
HMNXSV003008289
Hs.22583.0.S1_3p_at
Hs.87327.1.S1_3p_at
ILMN_1805996
PH_hs_0001974
TC15001666.hg
Participates
as an input of
TOPORS SUMOylates SIN3A with SUMO1 (Homo sapiens)
p53 and Sin3a bind c-Myb (Homo sapiens)
p53, SIN3A and MYB form a complex (Homo sapiens)
AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter (Homo sapiens)
AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter (Homo sapiens)
HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter (Homo sapiens)
HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter (Homo sapiens)
as a component of
Myb:SIN3A:p53 [nucleoplasm] (Homo sapiens)
p53:MYB:SIN3A [nucleoplasm] (Homo sapiens)
SIN3A:AcK685,p-Y705,p-S727 STAT3 dimer:PRDM1 gene [nucleoplasm] (Homo sapiens)
AcK685-p-Y705,S727 STAT3 dimer:SIN3A [nucleoplasm] (Homo sapiens)
HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] (Homo sapiens)
HINT1:HDAC1:SIN3A:TCF/LEF:CTNNB1:CCND1 gene [nucleoplasm] (Homo sapiens)
SIN3A:HDAC2 homodimer [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1 homodimer [nucleoplasm] (Homo sapiens)
SIN3A:HDAC1:HDAC2 [nucleoplasm] (Homo sapiens)
as a member of
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
Corepressors of PPARalpha [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-SIN3A [nucleoplasm]
Inferred To
Sin3a [nucleoplasm]
(Mus musculus)
Sin3a [nucleoplasm]
(Rattus norvegicus)
Sin3A [nucleoplasm]
(Drosophila melanogaster)
SIN3 [nucleoplasm]
(Saccharomyces cerevisiae)
sin3aa [nucleoplasm]
(Danio rerio)
SIN3A [nucleoplasm]
(Bos taurus)
SIN3A [nucleoplasm]
(Canis familiaris)
SIN3A [nucleoplasm]
(Dictyostelium discoideum)
SIN3A [nucleoplasm]
(Gallus gallus)
SIN3A [nucleoplasm]
(Sus scrofa)
pst1 [nucleoplasm]
(Schizosaccharomyces pombe)
sin3a [nucleoplasm]
(Xenopus tropicalis)
sin-3 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_006720529.1
,
NP_001138830.1
,
XP_006720528.1
,
NP_001138829.1
,
XP_006720530.1
,
NP_056292.1
OpenTargets
ENSG00000169375
GeneCards
Q96ST3
HPA
ENSG00000169375-SIN3A
Ensembl
ENSG00000169375
,
ENSP00000378403
,
ENSP00000378402
,
ENST00000565264
,
ENSP00000454296
,
ENSP00000515834
,
ENST00000360439
,
ENSP00000455204
,
ENST00000564778
,
ENST00000394949
,
ENST00000394947
,
ENST00000704312
,
ENSP00000353622
PRO
Q96ST3
Pharos - Targets
Q96ST3
Orphanet
24902
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.918
13
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.878
7
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.725
6
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.725
6
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.675
4
UniProt:Q9H160 ING2
2
monoSUMO1-K195-ING2 [nucleoplasm]
(R-HSA-4086075)
ING2 [nucleoplasm]
(R-HSA-3215167)
0.669
4
UniProt:O75446 SAP30
1
SAP30 [nucleoplasm]
(R-HSA-351693)
0.643
4
UniProt:Q8IV20 LACC1
0.643
5
UniProt:P12755 SKI
1
SKI [nucleoplasm]
(R-HSA-173473)
0.641
3
UniProt:P51610 HCFC1
2
HCFC1 [nucleoplasm]
(R-HSA-1592209)
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
0.605
6
UniProt:Q9UQ80 PA2G4
2
PA2G4 [extracellular region]
(R-HSA-6806200)
PA2G4 [azurophil granule lumen]
(R-HSA-6799205)
0.602
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.589
2
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.527
2
UniProt:Q9BUL5 PHF23
0.527
2
UniProt:P19784 CSNK2A2
2
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
CSNK2A2 [cytosol]
(R-HSA-201721)
0.527
2
UniProt:Q9UJV9 DDX41
4
DDX41 [nucleoplasm]
(R-HSA-9769601)
DDX41 [cytosol]
(R-HSA-3134807)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134942)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134941)
0.527
2
UniProt:P61244 MAX
1
MAX [nucleoplasm]
(R-HSA-3006627)
0.527
2
UniProt:Q8N344 MIER2
0.527
2
UniProt:O75182 SIN3B
1
SIN3B [nucleoplasm]
(R-HSA-3006450)
0.527
2
UniProt:Q9NP50 SHCAF
0.527
3
UniProt:Q9H7L9 SUDS3
2
K63polyUb-SUDS3 [nucleoplasm]
(R-HSA-6782790)
SUDS3 [nucleoplasm]
(R-HSA-351696)
0.527
2
UniProt:Q05195 MAD1
0.527
2
UniProt:Q6ZNC4 ZNF704
1
ZNF704 [nucleoplasm]
(R-HSA-2454141)
0.527
3
UniProt:P23246 SFPQ
3
SFPQ [cytosol]
(R-HSA-9635505)
p-Y-SFPQ [nucleoplasm]
(R-HSA-8849461)
SFPQ [nucleoplasm]
(R-HSA-3900138)
0.524
2
UniProt:P51608 MECP2
0.499
2
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.499
3
UniProt:Q1EHW4 SAP25
0.462
2
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.462
2
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