Reactome | SIN3A [nucleoplasm]

SIN3A [nucleoplasm]

Stable Identifier

R-HSA-351657

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SIN3A_HUMAN, Paired amphipathic helix protein Sin3a

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Locations in the PathwayBrowser for interactor UniProt:Q9UBL3

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External Reference Information

External Reference

UniProt:Q96ST3 SIN3A

Gene Names

SIN3A

Chain

chain:1-1273

Reference Genes

BioGPS Gene:25942 SIN3A

COSMIC (genes):SIN3A SIN3A

CTD Gene:25942 SIN3A

dbSNP Gene:25942 SIN3A

ENSEMBL:ENSG00000169375 SIN3A

HGNC:19353 SIN3A

KEGG Gene (Homo sapiens):25942 SIN3A

Monarch:25942 SIN3A

NCBI Gene:25942 SIN3A

OMIM:607776 SIN3A

UCSC:Q96ST3 SIN3A

Reference Transcript

Other Identifiers

0000540020

11730293_a_at

11730294_a_at

11735494_a_at

16811791

17121228

225135_at

238005_s_at

238006_at

25942

3633311

3633397

3633398

3633399

3633400

3633401

3633402

3633404

3633405

3633406

3633407

3633408

3633411

3633413

3633415

3633417

3633418

3633419

3633422

3633425

3633426

3633427

3633429

3633430

3633431

3633432

3633433

3633434

3633435

3633436

3633437

3633438

3633445

3633446

3633448

3633450

3633451

3633452

3633459

3638857

43176_at

49525_i_at

49527_r_at

7990487

82996_at

A_23_P367676

A_24_P304760

GE56490

GO:0000118

GO:0000122

GO:0000228

GO:0000278

GO:0000776

GO:0000785

GO:0000902

GO:0001102

GO:0001103

GO:0001701

GO:0002218

GO:0002230

GO:0002244

GO:0002376

GO:0003674

GO:0003677

GO:0003682

GO:0003714

GO:0003723

GO:0004407

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0006260

GO:0006355

GO:0006464

GO:0006476

GO:0006629

GO:0006950

GO:0007049

GO:0007568

GO:0008134

GO:0008150

GO:0008219

GO:0009058

GO:0009790

GO:0010243

GO:0010817

GO:0010971

GO:0016575

GO:0016580

GO:0016810

GO:0017053

GO:0019216

GO:0021895

GO:0030154

GO:0030516

GO:0031937

GO:0032991

GO:0034613

GO:0034641

GO:0040007

GO:0042592

GO:0042754

GO:0043066

GO:0043226

GO:0043619

GO:0044877

GO:0045652

GO:0045666

GO:0045892

GO:0045944

GO:0048511

GO:0048856

GO:0051276

GO:0051595

GO:0071333

GO:0140416

GO:1900181

GO:1901675

GO:1903351

GO:2000678

Hs.22583.0.S1_3p_at

Hs.87327.1.S1_3p_at

ILMN_1805996

PH_hs_0001974

TC15001666.hg

Participant Of

input

hasComponent

hasMember

Other forms of this molecule

SUMO1-SIN3A [nucleoplasm]

Inferred To

Sin3a [nucleoplasm] (Mus musculus)

Sin3a [nucleoplasm] (Rattus norvegicus)

SIN3 [nucleoplasm] (Saccharomyces cerevisiae)

sin3aa [nucleoplasm] (Danio rerio)

SIN3A [nucleoplasm] (Bos taurus)

SIN3A [nucleoplasm] (Canis familiaris)

SIN3A [nucleoplasm] (Dictyostelium discoideum)

SIN3A [nucleoplasm] (Gallus gallus)

SIN3A [nucleoplasm] (Sus scrofa)

pst1 [nucleoplasm] (Schizosaccharomyces pombe)

sin3a [nucleoplasm] (Xenopus tropicalis)

sin-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_006720529.1, XP_006720528.1, XP_006720530.1, NP_001138829.1, NP_001138830.1, NP_056292.1

OpenTargets

ENSG00000169375

GeneCards

Q96ST3

HPA

ENSG00000169375-SIN3A

Ensembl

ENSP00000353622, ENSP00000378403, ENSP00000378402, ENSG00000169375, ENST00000394949, ENST00000360439, ENST00000394947

PRO

Q96ST3

Orphanet

24902

PDB

1PO4

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.899	9
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) SUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.839	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.675	4
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.643	3
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.641	3
UniProt:P51610 HCFC1	2	K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821) HCFC1 [nucleoplasm] (R-HSA-1592209)	0.605	6
UniProt:Q9UQ80 PA2G4	2	PA2G4 [azurophil granule lumen] (R-HSA-6799205) PA2G4 [extracellular region] (R-HSA-6806200)	0.602	4
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.589	2
UniProt:Q9H160 ING2	2	ING2 [nucleoplasm] (R-HSA-3215167) SUMO1-K195-ING2 [nucleoplasm] (R-HSA-4086075)	0.564	2
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.527	2
UniProt:Q8IV20 LACC1			0.527	3
UniProt:P23246 SFPQ	3	p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138) SFPQ [cytosol] (R-HSA-9635505)	0.524	2
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.499	3
UniProt:P51608 MECP2			0.499	2
UniProt:Q1EHW4 SAP25			0.462	2
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.462	2

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