Reactome | SNW1 [nucleoplasm]

SNW1 [nucleoplasm]

Stable Identifier

R-HSA-351663

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SKIP, SNW domain-containing protein, SNW1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q13422 IKZF1

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - Downregulation of SMAD2/3:SMAD4 transcriptional activity (Homo sapiens)
        
        ATP1B4 binds SNW1 (Homo sapiens)
        
        SNW1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13573 SNW1

Gene Names

SNW1, SKIIP, SKIP

Chain

initiator methionine:, chain:2-536

Reference Genes

BioGPS Gene:22938 SNW1

COSMIC (genes):SNW1 SNW1

CTD Gene:22938 SNW1

dbSNP Gene:22938 SNW1

ENSEMBL:ENSG00000100603 SNW1

ENSEMBL_homo_sapiens_GENE:ENSG00000100603.14 SNW1

HGNC:16696 SNW1

KEGG Gene (Homo sapiens):22938 SNW1

Monarch:22938 SNW1

NCBI Gene:22938 SNW1

OMIM:603055 SNW1

UCSC:Q13573 SNW1

Reference Transcript

RefSeq:NM_012245.2 SNW1

Other Identifiers

11716088_s_at

11716089_x_at

11746296_a_at

11749747_s_at

11749748_x_at

16795226

201575_PM_at

201575_at

215424_PM_s_at

215424_s_at

22938

2343553

3573260

3573262

3573263

3573264

3573266

3573267

3573268

3573270

3573277

3573278

3573279

3573280

3573281

3573282

3573283

3573284

3573285

3573286

3573287

37715_at

7980463

A_23_P37347

GE54391

GO:0000122

GO:0000398

GO:0003713

GO:0003714

GO:0003723

GO:0005112

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0006351

GO:0006355

GO:0006357

GO:0006397

GO:0008024

GO:0008380

GO:0012501

GO:0016071

GO:0016363

GO:0016604

GO:0016607

GO:0016922

GO:0019899

GO:0023052

GO:0030154

GO:0030511

GO:0042771

GO:0042809

GO:0042974

GO:0043226

GO:0043923

GO:0045892

GO:0045944

GO:0046332

GO:0048026

GO:0048384

GO:0048385

GO:0048856

GO:0050681

GO:0050769

GO:0070562

GO:0070564

GO:0071007

GO:0071013

GO:0071300

GO:0140110

HMNXSV003031025

Hs.79008.1.S1_3p_a_at

ILMN_1688413

PH_hs_0026047

PH_hs_0033525

TC14001350.hg

U51432_at

g6912675_3p_at

Participates

as a component of

as an input of

Inferred To

snw1 [nucleoplasm] (Danio rerio)

snw1 [nucleoplasm] (Xenopus tropicalis)

Snw1 [nucleoplasm] (Mus musculus)

Snw1 [nucleoplasm] (Rattus norvegicus)

prp45 [nucleoplasm] (Schizosaccharomyces pombe)

snwA [nucleoplasm] (Dictyostelium discoideum)

Bx42 [nucleoplasm] (Drosophila melanogaster)

SNW1 [nucleoplasm] (Bos taurus)

SNW1 [nucleoplasm] (Caenorhabditis elegans)

SNW1 [nucleoplasm] (Canis familiaris)

SNW1 [nucleoplasm] (Gallus gallus)

SNW1 [nucleoplasm] (Plasmodium falciparum)

SNW1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_036377.1

OpenTargets

ENSG00000100603

HPA

ENSG00000100603-SNW1

GeneCards

Q13573

Ensembl

ENSP00000261531, ENST00000261531, ENSG00000100603

PRO

Q13573

Pharos - Targets

Q13573

PDB

5MQF, 6ICZ, 6ID1, 6ZYM, 7ABI, 6ID0, 7W59, 5YZG, 7W5B, 6QDV, 7DVQ, 6FF7, 5XJC, 7QTT, 7AAV, 7A5P, 7ABF, 8CH6, 5Z58, 6FF4, 7ABG, 7W5A, 8C6J

Interactors (157)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y3C6 PPIL1	1	PPIL1 [nucleoplasm] (R-HSA-8867892)	0.926	17
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.831	8
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.781	7
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.774	8
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.742	5
UniProt:P26368 U2AF2	2	5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011) U2AF2 [nucleoplasm] (R-HSA-71987)	0.727	6
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:Q15029 EFTUD2	1	EFTUD2 [nucleoplasm] (R-HSA-71883)	0.706	5
UniProt:Q86U42 PABPN1	2	PABPN1 [cytosol] (R-HSA-9822424) PABPN1 [nucleoplasm] (R-HSA-72008)	0.696	5
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.69	5
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.669	3
UniProt:Q9Y618 NCOR2	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.667	4
UniProt:P11473 VDR	2	polySUMO2-VDR [nucleoplasm] (R-HSA-4546376) VDR [nucleoplasm] (R-HSA-375512)	0.667	5
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.666	4
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.666	4
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.666	5
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.659	4
UniProt:Q9NQT4 EXOSC5	2	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550)	0.659	4
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.648	4
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725)	0.646	3
UniProt:Q9NYF8 BCLF1			0.643	4
UniProt:Q9UMS4 PRPF19	1	PRPF19 [nucleoplasm] (R-HSA-5420907)	0.643	4
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.643	5
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.643	3
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.643	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.639	7
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.632	4
UniProt:Q96NB3 ZNF830	1	ZNF830 [nucleoplasm] (R-HSA-6781962)	0.632	3
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.632	3
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.623	4
UniProt:Q9NVJ2 ARL8B			0.618	5
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.615	3
UniProt:P49140 SKI			0.602	4
UniProt:Q14008 CKAP5	1	CKAP5 [cytosol] (R-HSA-377729)	0.564	2
UniProt:Q6NT76 HMBX1			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q5BJF6-2 ODF2			0.556	3
UniProt:Q8IVT2 MISP			0.556	3
UniProt:Q86Z20 CC125			0.556	3
UniProt:O94985-2 CLSTN1			0.556	3
IntAct:EBI-22315148 CCSB ORF ID			0.556	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:P36544 CHRNA7	1	CHRNA7 [plasma membrane] (R-HSA-507830)	0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:Q96A72 MAGOHB	1	MAGOHB [nucleoplasm] (R-HSA-8867888)	0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:P41219 PERI			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q06547 GABPB1			0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:O94929-2 ABLIM3			0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q9BTE3-2 MCMBP			0.556	3
UniProt:Q69YQ0 CYTSA			0.556	3
UniProt:Q15276 RABEP1	1	RABEP1 [early endosome membrane] (R-HSA-2029004)	0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q8NHY3 GA2L2			0.556	3
UniProt:Q53EZ4 CEP55			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
IntAct:EBI-22554958 CCSB ORF ID			0.556	8
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:P30519 HMOX2	3	HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:Q8IYF3 TEX11			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P01112 HRAS	20	HRAS Q61R [plasma membrane] (R-HSA-6802458) HRAS Q61L [plasma membrane] (R-HSA-6802452) HRAS Q61K [plasma membrane] (R-HSA-6802442) HRAS G13R [plasma membrane] (R-HSA-6802368) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS [plasma membrane] (R-HSA-62717) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788)	0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
UniProt:Q4V328 GRAP1			0.556	3
UniProt:P21333-2 FLNA			0.556	3
UniProt:P62937-2 P629372			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:Q9NUJ3 T11L1			0.556	3
UniProt:P31153 MAT2A	1	MAT2A [cytosol] (R-HSA-174363)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.556	3
UniProt:Q5JTV8 TOR1AIP1	1	TOR1AIP1 [cytosol] (R-HSA-9715083)	0.556	3
UniProt:Q5SUL5 1A01			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q8TD16-2 BICD2			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:P22695 UQCRC2	1	UQCRC2 [mitochondrial inner membrane] (R-HSA-164280)	0.556	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.556	3
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:P07550 ADRB2	5	pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143) ADRB2 [endosome membrane] (R-HSA-6783036) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) pS-ADRB2 [plasma membrane] (R-HSA-8852158) ADRB2 [plasma membrane] (R-HSA-390647)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:P99999 CYCS	6	AcK-CYCS [mitochondrial intermembrane space] (R-HSA-5688308) Cytochrome c (oxidised) [mitochondrial inner membrane] (R-HSA-352607) CYCS [cytosol] (R-HSA-53259) CYCS [mitochondrial intermembrane space] (R-HSA-114244) apo-CYCS [mitochondrial inner membrane] (R-HSA-352608) Cytochrome c (reduced) [mitochondrial inner membrane] (R-HSA-352609)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.547	3
UniProt:P17863 SKI			0.543	4
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.527	2
UniProt:Q86VM9 ZCH18			0.527	2
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.527	2
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.527	2
UniProt:Q9BQ65 USB1			0.527	2
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.527	2
UniProt:O75934 BCAS2	1	BCAS2 [nucleoplasm] (R-HSA-5420902)	0.527	3
UniProt:Q96DI7 SNRNP40	1	SNRNP40 [nucleoplasm] (R-HSA-71877)	0.527	2
UniProt:Q96AT1 K1143			0.527	2
UniProt:P43243 MATR3			0.527	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	2
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.527	2
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.527	2
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.527	4
UniProt:Q9H4B7 TUBB1	6	TUBB1 folding intermediate [cytosol] (R-HSA-392793) TUBB1 unfolded [cytosol] (R-HSA-392782) Polyglycyl-TUBB1 [cytosol] (R-HSA-8867450) Polyglutamyl-TUBB1 [cytosol] (R-HSA-8867413) TUBB1 [axonemal microtubule] (R-HSA-5610437) TUBB1 [cytosol] (R-HSA-191703)	0.527	2
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.527	3
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	2
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	4
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.527	2
UniProt:P62304 SNRPE	2	SNRPE [nucleoplasm] (R-HSA-71905) SNRPE [cytosol] (R-HSA-191782)	0.527	4
UniProt:P23246 SFPQ	3	SFPQ [cytosol] (R-HSA-9635505) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.527	2
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.527	2
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.527	2
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.527	2
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.527	2
UniProt:P62318 SNRPD3	3	SNRPD3 [nucleoplasm] (R-HSA-71903) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) 2xMe-SNRPD3 [cytosol] (R-HSA-191781)	0.527	2
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.527	2
UniProt:P43246 MSH2	3	MSH2 R406* [nucleoplasm] (R-HSA-5575594) MSH2 [nucleoplasm] (R-HSA-5357525) MSH2 GLN601TER [nucleoplasm] (R-HSA-5577243)	0.527	2
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.527	2
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.524	3
UniProt:P43355 MAGA1			0.508	3
UniProt:Q96BM9 ARL8A	3	ARL8A [ficolin-1-rich granule membrane] (R-HSA-6801066) ARL8A [plasma membrane] (R-HSA-6801539) ARL8A [azurophil granule membrane] (R-HSA-6801069)	0.508	2
UniProt:O00409 FOXN3			0.508	3
UniProt:Q8WYA6 CTNNBL1	1	CTNNBL1 [nucleoplasm] (R-HSA-5420895)	0.508	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.508	3
UniProt:P48281	2	polySUMO2-VDR [nucleoplasm] (R-MMU-4546376) VDR [nucleoplasm] (R-MMU-375512)	0.508	2
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.508	2
UniProt:Q60974 Ncor1	3	Ncor1 [cytosol] (R-MMU-1253324) Ncor1 [nucleoplasm] (R-MMU-442459) Ncor1 [nucleoplasm] (R-MMU-442501)	0.508	3
UniProt:A0A0D6GID3 A0A0D6GID3			0.499	2
UniProt:Q96T37 RBM15			0.483	2
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.483	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2
UniProt:Q15233 NONO			0.483	2
UniProt:Q4G0J3 LARP7			0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [cytosol] (R-HSA-9727902) HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.483	2
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.483	2