Reactome | SAP30 [nucleoplasm]

SAP30 [nucleoplasm]

Stable Identifier

R-HSA-351693

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SAP30_HUMAN, Histone deacetylase complex subunit SAP30, 30 kDa Sin3-associated polypeptide

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        SAP30 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        SAP30 [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        SAP30 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        SAP30 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        SAP30 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        Sin3A complex [nucleoplasm] (Homo sapiens)
        
        Sin3a core complex [nucleoplasm] (Homo sapiens)
        
        SAP30 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75446 SAP30

Gene Names

SAP30

Chain

chain:1-220

Reference Genes

BioGPS Gene:8819 SAP30

COSMIC (genes):SAP30 SAP30

CTD Gene:8819 SAP30

dbSNP Gene:8819 SAP30

ENSEMBL:ENSG00000164105 SAP30

ENSEMBL:ENSG00000164105.4 SAP30

HGNC:10532 SAP30

KEGG Gene (Homo sapiens):8819 SAP30

Monarch:8819 SAP30

NCBI Gene:8819 SAP30

OMIM:603378 SAP30

UCSC:O75446 SAP30

Reference Transcript

RefSeq:NM_003864.3 SAP30

Other Identifiers

11727476_s_at

11727477_at

11758983_at

16972425

204899_PM_s_at

204899_s_at

204900_PM_x_at

204900_x_at

2700767

2700768

2700769

2752016

2752017

2752018

2752019

2752020

2752021

2752022

2752024

2752025

2752028

2752029

40992_s_at

40993_r_at

8098342

8819

A_23_P121602

GE79920

GO:0000118

GO:0000122

GO:0000228

GO:0003677

GO:0003712

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006351

GO:0006355

GO:0016580

GO:0023052

GO:0030154

GO:0030336

GO:0030512

GO:0035914

GO:0043226

GO:0046872

GO:0048856

GO:0048870

GO:0052472

GO:0140110

GO:1902455

GO:1902459

HMNXSV003054534

Hs.20985.0.S1_3p_a_at

ILMN_1700896

PH_hs_0026887

TC04000856.hg

g4506782_3p_a_at

Participates

as a component of

Inferred To

SAP30 [nucleoplasm] (Bos taurus)

SAP30 [nucleoplasm] (Canis familiaris)

SAP30 [nucleoplasm] (Danio rerio)

SAP30 [nucleoplasm] (Dictyostelium discoideum)

SAP30 [nucleoplasm] (Gallus gallus)

SAP30 [nucleoplasm] (Saccharomyces cerevisiae)

SAP30 [nucleoplasm] (Sus scrofa)

sap30 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of SAP30 [nucleoplasm] (Schizosaccharomyces pombe)

Sap30 [nucleoplasm] (Drosophila melanogaster)

Sap30 [nucleoplasm] (Mus musculus)

Sap30 [nucleoplasm] (Rattus norvegicus)

sap30l [nucleoplasm] (Danio rerio)

Homologues of SAP30 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_003855.1

OpenTargets

ENSG00000164105

GeneCards

O75446

HPA

ENSG00000164105-SAP30

Ensembl

ENSP00000296504, ENST00000296504, ENSG00000164105

PRO

O75446

Pharos - Targets

O75446

PDB

2KDP

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	5
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	3
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.527	2
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.527	2
UniProt:Q9H160 ING2	2	monoSUMO1-K195-ING2 [nucleoplasm] (R-HSA-4086075) ING2 [nucleoplasm] (R-HSA-3215167)	0.527	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.527	2