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DSG2(?-1118) [plasma membrane]
Stable Identifier
R-HSA-351839
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Desmoglein 2 (70 Kd fragment)
Locations in the PathwayBrowser for interactor UniProt:P11279
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Apoptotic cleavage of cell adhesion proteins (Homo sapiens)
Caspase-mediated cleavage of Desmoglein 2 (Homo sapiens)
DSG2(?-1118) [plasma membrane] (Homo sapiens)
General
The caspase 3-mediated proteolytic processing of full-length Dsg2, the most widespread desmosomal cadherin, results in disappearance of Dsg2 from the cell surface and appearance of a 70-kDa fragment in the cytosol. Loss of Dsg2 from the cell surface may contribute to the progressive loss of intercellular adhesion strength during apoptosis (Cirillo et al., 2008)
External Reference Information
External Reference
UniProt:Q14126 DSG2
Gene Names
DSG2, CDHF5
Chain
signal peptide:1-23, propeptide:24-49, chain:50-1118
Reference Genes
BioGPS Gene:1829 DSG2
COSMIC (genes):DSG2 DSG2
CTD Gene:1829 DSG2
dbSNP Gene:1829 DSG2
ENSEMBL:ENSG00000046604 DSG2
ENSEMBL_homo_sapiens_GENE:ENSG00000046604.14 DSG2
HGNC:3049 DSG2
KEGG Gene (Homo sapiens):1829 DSG2
Monarch:1829 DSG2
NCBI Gene:1829 DSG2
OMIM:125671 DSG2
UCSC:Q14126 DSG2
Reference Transcript
RefSeq:NM_001943.4 DSG2
Other Identifiers
11725523_at
11725524_s_at
11725525_at
1553105_PM_s_at
1553105_s_at
16851768
1829
217901_PM_at
217901_at
244545_PM_at
244545_at
33468_at
3783531
3783532
3783539
3783540
3783541
3783542
3783543
3783545
3783547
3783548
3783549
3783550
3783551
3783552
3783553
3783554
3783555
3783556
3783557
3783558
3783559
3783560
3783561
3783562
3783564
52016_at
75487_at
79641_at
8020779
A_14_P200506
A_23_P141730
GE60381
GO:0001533
GO:0002934
GO:0003012
GO:0003013
GO:0003165
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0005911
GO:0007155
GO:0007156
GO:0009986
GO:0014704
GO:0016020
GO:0016324
GO:0016328
GO:0022414
GO:0030054
GO:0030057
GO:0032570
GO:0034330
GO:0043226
GO:0043231
GO:0046872
GO:0048856
GO:0050839
GO:0060135
GO:0070062
GO:0070161
GO:0086073
GO:0086083
GO:0086091
GO:0098609
GO:0098631
GO:0098911
HMNXSV003043308
Hs.2631.0.A2_3p_at
Hs.310525.0.S1_3p_at
Hs2.359784.1.S1_3p_s_at
ILMN_1704196
PH_hs_0024907
TC18000128.hg
Z26317_at
Participates
as an output of
Caspase-mediated cleavage of Desmoglein 2 (Homo sapiens)
Other forms of this molecule
DSG2 [cornified envelope]
DSG2 [plasma membrane]
Inferred To
DSG2(?-1118) [plasma membrane]
(Gallus gallus)
DSG2 [plasma membrane]
(Bos taurus)
DSG2 [plasma membrane]
(Canis familiaris)
DSG2 [plasma membrane]
(Sus scrofa)
dsg2.1 [plasma membrane]
(Danio rerio)
cdh-4 [plasma membrane]
(Caenorhabditis elegans)
Dsg2 [plasma membrane]
(Mus musculus)
Dsg2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001934.2
OpenTargets
ENSG00000046604
GeneCards
Q14126
HPA
ENSG00000046604-DSG2
Ensembl
ENSP00000261590
,
ENSG00000046604
,
ENST00000261590
PRO
Q14126
Pharos - Targets
Q14126
Orphanet
15894
HMDB Protein
HMDBP07659
PDB
6QNU
,
6QNT
,
7A7D
,
7AGG
,
5ERD
,
7AGF
,
6SIT
,
5J5J
,
2YQG
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6J9G0 STYK1
0.483
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
11
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