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CASP8(217-374) [mitochondrial outer membrane]
Stable Identifier
R-HSA-351869
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
CASP8, p18 subunit of Caspase 8
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase mediated cleavage of BAP31 (Homo sapiens)
active caspase-8 [mitochondrial outer membrane] (Homo sapiens)
Caspase-8 dimer [mitochondrial outer membrane] (Homo sapiens)
CASP8(217-374) [mitochondrial outer membrane] (Homo sapiens)
Translocation of active caspase-8 to the mitochondrial membrane (Homo sapiens)
active caspase-8 [mitochondrial outer membrane] (Homo sapiens)
Caspase-8 dimer [mitochondrial outer membrane] (Homo sapiens)
CASP8(217-374) [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14790 CASP8
Gene Names
CASP8, MCH5
Chain
propeptide:1-216, chain:217-374, propeptide:375-384, chain:385-479
Reference Genes
BioGPS Gene:841 CASP8
COSMIC (genes):CASP8 CASP8
CTD Gene:841 CASP8
dbSNP Gene:841 CASP8
ENSEMBL:ENSG00000064012 CASP8
ENSEMBL_homo_sapiens_GENE:ENSG00000064012.24 CASP8
HGNC:1509 CASP8
KEGG Gene (Homo sapiens):841 CASP8
Monarch:841 CASP8
NCBI Gene:841 CASP8
OMIM:601763 CASP8
UCSC:Q14790 CASP8
Reference Transcript
RefSeq:XM_005246890.3 CASP8
RefSeq:NM_033356.3 CASP8
RefSeq:XM_005246891.4 CASP8
RefSeq:NM_033358.3 CASP8
RefSeq:XM_005246892.1 CASP8
RefSeq:NM_001080124.1 CASP8
RefSeq:XM_005246886.1 CASP8
RefSeq:XM_006712789.1 CASP8
RefSeq:XM_005246887.1 CASP8
RefSeq:NM_001080125.1 CASP8
RefSeq:XM_006712790.3 CASP8
RefSeq:XM_005246888.1 CASP8
RefSeq:NM_001228.4 CASP8
RefSeq:XM_006712793.2 CASP8
RefSeq:XM_005246889.1 CASP8
RefSeq:NM_033355.3 CASP8
Other Identifiers
11728978_x_at
11741554_x_at
11742324_a_at
11749790_a_at
11754153_x_at
11756062_x_at
1553306_at
207686_PM_s_at
207686_s_at
213373_PM_s_at
213373_s_at
2522729
2522730
2522731
2522732
2522733
2522743
2522744
2522745
2522746
2522747
2522750
2522751
2522752
2522753
2522755
2522756
2522758
2522759
2522764
2522766
2522768
2522769
2522770
2522771
3104672
31491_s_at
33774_at
33775_s_at
8047419
841
A_14_P116206
A_14_P138041
A_23_P209389
A_24_P148499
A_24_P157087
GE60202
GO:0001525
GO:0001817
GO:0002376
GO:0003824
GO:0004197
GO:0005123
GO:0005164
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005856
GO:0005886
GO:0006508
GO:0006915
GO:0007507
GO:0008233
GO:0008234
GO:0008625
GO:0010803
GO:0012501
GO:0016485
GO:0016787
GO:0022414
GO:0023052
GO:0030027
GO:0030101
GO:0030154
GO:0030163
GO:0030225
GO:0030335
GO:0031264
GO:0031265
GO:0031625
GO:0032025
GO:0032355
GO:0032496
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042110
GO:0042113
GO:0042802
GO:0042981
GO:0043065
GO:0043123
GO:0043124
GO:0043226
GO:0043525
GO:0044297
GO:0044877
GO:0045088
GO:0045471
GO:0045651
GO:0045862
GO:0048856
GO:0048870
GO:0051603
GO:0051604
GO:0051716
GO:0060546
GO:0060715
GO:0070269
GO:0071260
GO:0071407
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097202
GO:0097264
GO:0097342
GO:0098542
GO:0140096
HMNXSV003024001
HMNXSV003029851
Hs.19949.2.S2_3p_a_at
Hs2.381231.5.S1_3p_at
ILMN_1673757
ILMN_1787749
ILMN_1809313
ILMN_2377733
PH_hs_0023198
TC02003767.hg
X98172_at
X98176_at
X98178_s_at
g4502582_3p_a_at
Participates
as a component of
Caspase-8 dimer [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
CASP8(1-374) [cytosol]
CASP8(385-479) [mitochondrial outer membrane]
CASP8(385-479) [cytosol]
CASP8(375-384) [cytosol]
CASP8(217-374) [cytosol]
CASP8(1-216) [cytosol]
CASP8(1-479) [cytosol]
Inferred To
casp10 [mitochondrial outer membrane]
(Danio rerio)
CASP8 [mitochondrial outer membrane]
(Bos taurus)
CASP8 [mitochondrial outer membrane]
(Canis familiaris)
CASP8 [mitochondrial outer membrane]
(Sus scrofa)
CASP8(217-374) [mitochondrial outer membrane]
(Gallus gallus)
Casp8 [mitochondrial outer membrane]
(Mus musculus)
Casp8 [mitochondrial outer membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001073593.1
,
XP_006712856.1
,
NP_203519.1
,
XP_006712853.1
,
XP_005246943.1
,
XP_006712852.1
,
XP_005246949.1
,
NP_001219.2
,
NP_001073594.1
,
XP_005246946.1
,
XP_005246947.1
,
XP_005246944.1
,
XP_005246948.1
,
NP_203520.1
,
NP_203522.1
,
XP_005246945.1
Guide to Pharmacology - Targets
1624
OpenTargets
ENSG00000064012
ZINC - Substances
CASP8_HUMAN
ZINC target
Q14790
PRO
Q14790
PDB
1QTN
,
2Y1L
,
7LVJ
,
5JQE
,
4ZBW
,
2FUN
,
3H11
,
5H33
,
6PX9
,
4PS1
,
2C2Z
,
3KJN
,
5H31
,
1I4E
,
7DEE
,
4PRZ
,
5L08
,
6AGW
,
3KJQ
,
4JJ7
,
1F9E
,
2K7Z
,
7LVM
,
1QDU
ZINC - Investigational
CASP8_HUMAN
GeneCards
Q14790
HPA
ENSG00000064012-CASP8
Ensembl
ENSP00000388306
,
ENST00000440732
,
ENSP00000512370
,
ENST00000413726
,
ENST00000447616
,
ENST00000392263
,
ENSP00000512382
,
ENSP00000351273
,
ENST00000432109
,
ENST00000696087
,
ENSG00000064012
,
ENSP00000397528
,
ENST00000444430
,
ENST00000673742
,
ENSP00000264275
,
ENSP00000412523
,
ENST00000358485
,
ENSP00000501268
,
ENSP00000394434
,
ENSP00000512369
,
ENST00000323492
,
ENSP00000325722
,
ENST00000264275
,
ENSP00000376087
,
ENSP00000396869
,
ENST00000392258
,
ENST00000696068
,
ENST00000696067
,
ENSP00000376091
Pharos - Targets
Q14790
ZINC - Predictions - Purchasable
CASP8_HUMAN
Orphanet
16839
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.98
47
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.959
30
UniProt:P25445 FAS
1
FAS [plasma membrane]
(R-HSA-66248)
0.92
16
UniProt:P50591 TNFSF10
1
TNFSF10 [extracellular region]
(R-HSA-66186)
0.919
20
UniProt:O00220 TNFRSF10A
1
TNFRSF10A [plasma membrane]
(R-HSA-5633393)
0.817
11
UniProt:O14763 TNFRSF10B
1
TNFRSF10B [plasma membrane]
(R-HSA-65505)
0.749
7
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.744
5
UniProt:O15519 CFLAR
1
CFLAR(1-376) [cytosol]
(R-HSA-51925)
0.744
10
UniProt:Q92851 CASP10
4
CASP10(220-415) [cytosol]
(R-HSA-933458)
CASP10(1-219) [cytosol]
(R-HSA-933454)
CASP10(416-521) [cytosol]
(R-HSA-933455)
CASP10(1-521) [cytosol]
(R-HSA-933453)
0.734
6
UniProt:Q15628 TRADD
1
TRADD [cytosol]
(R-HSA-66376)
0.725
6
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.704
4
UniProt:Q9UKL3 CASP8AP2
2
monoSUMO1-K1813-CASP8AP2 [nucleoplasm]
(R-HSA-3927850)
CASP8AP2 [nucleoplasm]
(R-HSA-3927945)
0.704
5
UniProt:P25445-1 FAS
0.669
3
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.602
6
UniProt:P51572 BCAP31
6
BCAP31 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985503)
BCAP31 [endoplasmic reticulum membrane]
(R-HSA-9714333)
BCAP31(2-245) [endoplasmic reticulum membrane]
(R-HSA-201587)
BCAP31(165-237) [endoplasmic reticulum membrane]
(R-HSA-351909)
BCAP31(2-164) [endoplasmic reticulum membrane]
(R-HSA-351826)
BCAP31(238-246) [cytosol]
(R-HSA-351912)
0.589
3
UniProt:O15519-1 CFLAR
5
M1polyUb-K351,K353-CFLAR(1-480) [cytosol]
(R-HSA-9794015)
CFLAR(377-480) [cytosol]
(R-HSA-3465483)
K63polyUb-CFLAR(1-480) [cytosol]
(R-HSA-9818805)
CFLAR(1-376) [cytosol]
(R-HSA-3465408)
CFLAR(1-480) [cytosol]
(R-HSA-3371356)
0.564
2
UniProt:Q9Y572 RIPK3
8
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
0.564
2
UniProt:Q96AX1 VPS33A
1
VPS33A [endosome membrane]
(R-HSA-2197804)
0.556
3
UniProt:P13051-2 UNG
0.556
3
UniProt:Q06787-7 FMR1
0.556
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.556
3
UniProt:Q9BY76 ANGPTL4
3
ANGPTL4 [extracellular region]
(R-HSA-381271)
ANGPTL4 [extracellular region]
(R-HSA-6784897)
ANGPTL4(164-406) [extracellular region]
(R-HSA-9762251)
0.547
2
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.527
2
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.527
3
UniProt:O60936 NOL3
0.524
3
UniProt:P29350 PTPN6
5
PTPN6 [specific granule lumen]
(R-HSA-6799641)
PTPN6 [extracellular region]
(R-HSA-6806315)
PTPN6 [tertiary granule lumen]
(R-HSA-6800952)
PTPN6 [nucleoplasm]
(R-HSA-9008911)
PTPN6 [cytosol]
(R-HSA-197938)
0.524
3
UniProt:Q969K3 RNF34
2
RNF34 [nucleoplasm]
(R-HSA-6804442)
RNF34 [cytosol]
(R-HSA-975998)
0.508
3
UniProt:Q9Y3D6 FIS1
2
FIS1 [peroxisomal membrane]
(R-HSA-9033123)
FIS1 [cytosol]
(R-HSA-9033099)
0.499
2
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.499
3
UniProt:Q9UDY8 MALT1
1
MALT1 [cytosol]
(R-HSA-202461)
0.499
10
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