Caspase-mediated cleavage of occludin

Stable Identifier
R-HSA-351876
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Following iinduction of apoptosis in epithelial cells, tight junction are disrupted. Tight junction proteins, including the the transmembrane protein occludin and the cytoplasmic adaptor proteins ZO-1 and ZO-2 are fragmented by caspase cleavage (Bojarski et al., 2004). Inhibition of caspase-3 prevents cleavage of occludin, implicating caspase-3 as the responsible endopeptidase (Bojarski et al. 2004).
Literature References
PubMed ID Title Journal Year
15054114 The specific fates of tight junction proteins in apoptotic epithelial cells

Fromm, M, Mankertz, J, Weiske, J, Florian, P, Tauber, R, Schulzke, JD, Schröder, W, Bojarski, C, Huber, O, Schöneberg, T

J Cell Sci 2004
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Orthologous Events
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