Reactome | MST4 [cytosol]

MST4 [cytosol]

Stable Identifier

R-HSA-351918

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MASK

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9P289 STK26

Gene Names

STK26, MASK, MST4

Chain

initiator methionine:, chain:2-416

Reference Genes

BioGPS Gene:51765 STK26

COSMIC (genes):STK26 STK26

CTD Gene:51765 STK26

dbSNP Gene:51765 STK26

ENSEMBL:ENSG00000134602 STK26

HGNC:18174 STK26

KEGG:hsa:51765 STK26

Monarch:51765 STK26

NCBI Gene:51765 STK26

OMIM:300547 STK26

UCSC:Q9P289 STK26

Reference Transcript

Participates

as an input of

Caspase-mediated cleavage of MASK (Homo sapiens)

Other forms of this molecule

MST4(1-305) [cytosol]

MST4(306-416) [cytosol]

Inferred To

MST4 [cytosol] (Danio rerio)

MST4 [cytosol] (Dictyostelium discoideum)

MST4 [cytosol] (Gallus gallus)

MST4 [cytosol] (Mus musculus)

MST4 [cytosol] (Rattus norvegicus)

MST4 [cytosol] (Saccharomyces cerevisiae)

MST4 [cytosol] (Schizosaccharomyces pombe)

MST4 [cytosol] (Sus scrofa)

MST4 [cytosol] (Xenopus tropicalis)

Homologues of MST4 [cytosol] (Dictyostelium discoideum)

Homologues of MST4 [cytosol] (Schizosaccharomyces pombe)

STK26 [cytosol] (Bos taurus)

STK26 [cytosol] (Canis familiaris)

Cross References

Guide to Pharmacology - Targets

2287

OpenTargets

ENSG00000134602

ENSEMBL

ENST00000394334, ENSP00000419702, ENSP00000377868, ENSG00000134602, ENSP00000377867, ENST00000394335, ENST00000496850

ZINC - FDA approved

STK26_HUMAN

ZINC - Substances

STK26_HUMAN

ZINC - Biogenic

STK26_HUMAN

ZINC target

Q9P289

PRO

Q9P289

GlyGen

Q9P289

PDB

4FZF, 5XY9, 5YF4, 4GEH, 4FZD, 7B36, 3W8I, 4FZA, 3GGF

ZINC - Investigational

STK26_HUMAN

HPA

ENSG00000134602-STK26

GeneCards

STK26

Pharos - Targets

Q9P289

ZINC - Predictions - Purchasable

STK26_HUMAN

HMDB Protein

HMDBP08763

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BUL8 PDC10			0.924	11
UniProt:Q13033 STRN3			0.877	10
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.864	7
UniProt:Q9Y3A3 PHOCN			0.812	6
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.81	7
UniProt:Q9P2B4 CT2NL			0.794	6
UniProt:O00506 STK25			0.788	6
UniProt:Q14BN4 SLMAP			0.788	5
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.788	5
UniProt:Q8WZ74 CTTB2			0.758	5
UniProt:Q9ULQ0 STRP2			0.725	4
UniProt:Q9Y6E0 STK24	4	STK24 [cytosol] (R-HSA-351829) STK24(1-313) [cytosol] (R-HSA-351892) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [nucleoplasm] (R-HSA-351944)	0.725	6
UniProt:Q9NRL3 STRN4			0.725	4
UniProt:Q5VSL9 STRP1			0.708	4
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.643	3
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.643	4
UniProt:Q9P289 STK26	3	MST4 [cytosol] (R-HSA-351918) MST4(1-305) [cytosol] (R-HSA-351855) MST4(306-416) [cytosol] (R-HSA-351903)	0.593	4
UniProt:Q9Y376 CAB39	4	CAB39 [cytosol] (R-HSA-380969) CAB39 [ficolin-1-rich granule lumen] (R-HSA-6801287) CAB39 [extracellular region] (R-HSA-6806462) CAB39 [secretory granule lumen] (R-HSA-6801288)	0.544	6
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.527	2
UniProt:Q9Y228 T3JAM			0.527	3
UniProt:Q7L7X3 TAOK1	1	TAOK1 [cytosol] (R-HSA-376248)	0.527	2
UniProt:Q9NVK5 FGFR1OP2	2	FGFR1OP(1-132)-FGFR1(429-822) fusion [cytosol] (R-HSA-1606443) FGFR1OP(1-132)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838998)	0.527	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.519	6

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