Reactome | MST4 [cytosol]

MST4 [cytosol]

Stable Identifier

R-HSA-351918

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MASK

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9P289 STK26

Gene Names

STK26, MASK, MST4

Chain

initiator methionine:1, chain:2-416

Reference Genes

BioGPS Gene:51765 STK26

COSMIC (genes):STK26 STK26

CTD Gene:51765 STK26

dbSNP Gene:51765 STK26

ENSEMBL:ENSG00000134602 STK26

HGNC:18174 STK26

KEGG Gene (Homo sapiens):51765 STK26

Monarch:51765 STK26

NCBI Gene:51765 STK26

OMIM:300547 STK26

UCSC:Q9P289 STK26

Reference Transcript

Other Identifiers

0005390050

11720115_a_at

11720116_a_at

11741309_x_at

11747272_a_at

17106997

218499_PM_at

218499_at

224407_PM_s_at

224407_s_at

3991113

3991114

3991115

3991116

3991117

3991126

3991129

3991131

3991132

3991133

3991135

3991136

3991138

3991139

3991141

3991142

3991143

3991145

3991146

43456_at

51765

54316_at

8169949

A_14_P113118

A_23_P32414

GE53978

GO:0000166

GO:0000287

GO:0003674

GO:0004672

GO:0004674

GO:0004712

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005794

GO:0005798

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006915

GO:0006950

GO:0008150

GO:0008219

GO:0009267

GO:0012506

GO:0016020

GO:0016301

GO:0016310

GO:0016324

GO:0016740

GO:0022607

GO:0030033

GO:0030336

GO:0031410

GO:0040011

GO:0042542

GO:0042802

GO:0042803

GO:0042981

GO:0043167

GO:0043226

GO:0046777

GO:0046872

GO:0048471

GO:0048870

GO:0070062

GO:0071944

GO:0106310

GO:1903205

HMNXSV003027586

ILMN_1676159

ILMN_2328776

PH_hs_0002081

TC0X000628.hg

g13549066_3p_s_at

g7706568_3p_at

Participates

as an input of

Caspase-mediated cleavage of MASK (Homo sapiens)

Other forms of this molecule

MST4(306-416) [cytosol]

MST4(1-305) [cytosol]

Inferred To

gck-1 [cytosol] (Caenorhabditis elegans)

KIC1 [cytosol] (Saccharomyces cerevisiae)

MST4 [cytosol] (Dictyostelium discoideum)

Stk26 [cytosol] (Mus musculus)

Stk26 [cytosol] (Rattus norvegicus)

nak1 [cytosol] (Schizosaccharomyces pombe)

svkA [cytosol] (Dictyostelium discoideum)

stk26 [cytosol] (Danio rerio)

stk26 [cytosol] (Xenopus tropicalis)

Homologues of MST4 [cytosol] (Dictyostelium discoideum)

Homologues of MST4 [cytosol] (Schizosaccharomyces pombe)

GckIII [cytosol] (Drosophila melanogaster)

ppk11 [cytosol] (Schizosaccharomyces pombe)

sid1 [cytosol] (Schizosaccharomyces pombe)

STK26 [cytosol] (Bos taurus)

STK26 [cytosol] (Canis familiaris)

STK26 [cytosol] (Gallus gallus)

STK26 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001035917.1, NP_057626.2, NP_001035918.1

ZINC - World Drugs

STK26_HUMAN

Guide to Pharmacology - Targets

2287

OpenTargets

ENSG00000134602

ZINC - FDA approved

STK26_HUMAN

ZINC - Substances

STK26_HUMAN

ZINC - Biogenic

STK26_HUMAN

ZINC target

Q9P289

PRO

Q9P289

PDB

5XY9, 3W8I, 4GEH, 4FZF, 5YF4, 4FZA, 4FZD, 7B36, 3GGF

GeneCards

Q9P289

HPA

ENSG00000134602-STK26

Ensembl

ENSP00000377868, ENSP00000377867, ENST00000496850, ENST00000394334, ENSG00000134602, ENST00000394335, ENSP00000419702

Pharos - Targets

Q9P289

ZINC - Predictions - Purchasable

STK26_HUMAN

HMDB Protein

HMDBP08763

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BUL8 PDC10			0.86	8
UniProt:Q13033 STRN3			0.794	7
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.773	5
UniProt:Q9Y3A3 PHOCN			0.758	5
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.755	6
UniProt:Q9P2B4 CT2NL			0.737	5
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.725	4
UniProt:Q14BN4 SLMAP			0.725	4
UniProt:Q8WZ74 CTTB2			0.69	4
UniProt:Q9NRL3 STRN4			0.643	3
UniProt:O00506 STK25			0.643	4
UniProt:Q9Y6E0 STK24	4	STK24(1-313) [nucleoplasm] (R-HSA-351944) STK24(314-443) [cytosol] (R-HSA-351898) STK24(1-313) [cytosol] (R-HSA-351892) STK24 [cytosol] (R-HSA-351829)	0.643	4
UniProt:Q5VSL9 STRP1			0.623	3
UniProt:Q9P289 STK26	3	MST4(306-416) [cytosol] (R-HSA-351903) MST4(1-305) [cytosol] (R-HSA-351855) MST4 [cytosol] (R-HSA-351918)	0.593	4
UniProt:Q9Y376 CAB39	4	CAB39 [secretory granule lumen] (R-HSA-6801288) CAB39 [extracellular region] (R-HSA-6806462) CAB39 [ficolin-1-rich granule lumen] (R-HSA-6801287) CAB39 [cytosol] (R-HSA-380969)	0.544	6
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939)	0.527	2
UniProt:Q9BRV8 SIKE1	1	SIKE1 [cytosol] (R-HSA-916828)	0.527	2
UniProt:Q7L7X3 TAOK1	1	TAOK1 [cytosol] (R-HSA-376248)	0.527	2
UniProt:Q9ULQ0 STRP2			0.527	2

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