Reactome | CASP7(24-198) [nucleoplasm]

CASP7(24-198) [nucleoplasm]

Stable Identifier

R-HSA-351927

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Caspase-7 (large subunit)

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P55210 CASP7

Gene Names

CASP7, MCH3

Chain

initiator methionine:, propeptide:2-23, chain:24-198, propeptide:199-206, chain:207-303

Reference Genes

COSMIC (genes):CASP7 CASP7

ENSEMBL:ENSG00000165806 CASP7

HGNC:1508 CASP7

UCSC:P55210 CASP7

Other Identifiers

11719647_a_at

11719648_a_at

11728226_a_at

11750198_a_at

16709386

207181_PM_s_at

207181_s_at

3264950

3264951

3264952

3264953

3264954

3264956

3264957

3264959

3264965

3264976

3264977

3264978

3264979

3264980

3264981

3264982

3264984

3264986

3264987

3264988

3264989

3264991

38281_at

7930577

840

A_14_P117796

A_23_P12572

GE59348

GO:0003723

GO:0003824

GO:0004190

GO:0004197

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0006915

GO:0007507

GO:0008233

GO:0008234

GO:0009411

GO:0012501

GO:0016485

GO:0016787

GO:0030154

GO:0030163

GO:0042742

GO:0043226

GO:0043525

GO:0044346

GO:0048856

GO:0051146

GO:0051402

GO:0051604

GO:0070227

GO:0071222

GO:0071887

GO:0072734

GO:0097153

GO:0097194

GO:0097200

GO:0098542

GO:0140096

GO:1905686

HMNXSV003037170

ILMN_1730332

ILMN_2362974

ILMN_2373763

PH_hs_0000966

TC10000825.hg

U67319_at

g4502580_3p_a_at

Participates

as a component of

CASP7(24-198):CASP7(207-303) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

CASP7(207-303) [nucleoplasm]

CASP7(2-303) [cytosol]

CASP7(24-198) [cytosol]

CASP7(207-303) [cytosol]

Inferred To

Casp7 [nucleoplasm] (Mus musculus)

Casp7 [nucleoplasm] (Rattus norvegicus)

CASP7 [nucleoplasm] (Bos taurus)

CASP7 [nucleoplasm] (Canis familiaris)

CASP7 [nucleoplasm] (Gallus gallus)

CASP7 [nucleoplasm] (Sus scrofa)

casp7 [nucleoplasm] (Danio rerio)

casp7 [nucleoplasm] (Xenopus tropicalis)

Cross References

ZINC - Investigational

CASP7_HUMAN

Guide to Pharmacology - Targets

1623

ENSEMBL

ENSP00000358337, ENST00000614447, ENST00000621607, ENSP00000358324, ENSP00000480584, ENST00000369318, ENST00000621345, ENSP00000478285, ENST00000345633, ENSP00000298701, ENST00000369315, ENST00000452490, ENSP00000478999, ENST00000369331, ENSP00000398107, ENSP00000358321

OpenTargets

ENSG00000165806

HPA

ENSG00000165806-CASP7

ZINC - Substances

CASP7_HUMAN

ZINC target

P55210

PRO

P55210

Pharos - Targets

P55210

ZINC - Predictions - Purchasable

CASP7_HUMAN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.836	6
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.718	6
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.641	3
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.619	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	12
UniProt:P17405 SMPD1	1	SMPD1 [lysosomal lumen] (R-HSA-1605710)	0.537	6
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.508	2

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