Caspase-mediated cleavage of claspin

Stable Identifier
R-HSA-351936
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Claspin is cleaved by caspase-7 during the initiation of apoptosis following DNA damage (Clarke et al., 2005). Claspin is cleaved at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contain different functional domains. Only the large N-terminal fragment retains Chk1 binding activity. The smaller C-terminal fragment associates with DNA and inhibits the DNA-dependent phosphorylation of Chk1 associated with its activation indicating that cleavage of Claspin by caspase-7 inactivates the Chk1 signaling pathway (Clarke et al., 2005).

Literature References
PubMed ID Title Journal Year
16123041 Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway

Clarke, CA, Clarke, PR, Bennett, LN

J Biol Chem 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-7 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created