Reactome | SLC7A5 [plasma membrane]

SLC7A5 [plasma membrane]

Stable Identifier

R-HSA-352224

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Large neutral amino acids transporter small subunit 1, LAT1, L-type amino acid transporter 1

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Cell surface interactions at the vascular wall (Homo sapiens)
  - Basigin interactions (Homo sapiens)
    - Basigin binds CD98 complex (Homo sapiens)
      - Basigin:CD98hc complex [plasma membrane] (Homo sapiens)
        
        CD98hc complex [plasma membrane] (Homo sapiens)
        
        SLC7A5:SLC3A2 [plasma membrane] (Homo sapiens)
        
        SLC7A5 [plasma membrane] (Homo sapiens)
      - CD98hc complex [plasma membrane] (Homo sapiens)
        
        SLC7A5:SLC3A2 [plasma membrane] (Homo sapiens)
        
        SLC7A5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01650 SLC7A5

Gene Names

SLC7A5, CD98LC, LAT1, MPE16

Chain

chain:1-507

Reference Genes

BioGPS Gene:8140 SLC7A5

COSMIC (genes):SLC7A5 SLC7A5

CTD Gene:8140 SLC7A5

dbSNP Gene:8140 SLC7A5

ENSEMBL:ENSG00000103257 SLC7A5

ENSEMBL_homo_sapiens_GENE:ENSG00000103257.9 SLC7A5

HGNC:11063 SLC7A5

KEGG Gene (Homo sapiens):8140 SLC7A5

Monarch:8140 SLC7A5

NCBI Gene:8140 SLC7A5

OMIM:600182 SLC7A5

UCSC:Q01650 SLC7A5

Reference Transcript

RefSeq:NM_003486.6 SLC7A5

Other Identifiers

11739060_s_at

11739061_at

16829085

201195_PM_s_at

201195_s_at

32186_at

3687070

3703886

3703887

3703888

3703889

3703890

3703891

3703892

3703893

3703894

3703897

3703900

3703901

3703902

3703903

3703904

3703906

3703916

3703917

3703933

3703934

8003298

8140

A_24_P335620

GE81288

GO:0002376

GO:0002720

GO:0003013

GO:0003333

GO:0005215

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005886

GO:0006865

GO:0006914

GO:0009925

GO:0010507

GO:0010629

GO:0012501

GO:0014850

GO:0015171

GO:0015173

GO:0015175

GO:0015179

GO:0015190

GO:0015196

GO:0015297

GO:0015349

GO:0015804

GO:0015807

GO:0015818

GO:0015820

GO:0015821

GO:0015823

GO:0015824

GO:0015827

GO:0015828

GO:0015829

GO:0016020

GO:0016323

GO:0016324

GO:0022857

GO:0030154

GO:0031528

GO:0032328

GO:0032729

GO:0032740

GO:0032753

GO:0042149

GO:0042605

GO:0042908

GO:0043226

GO:0043231

GO:0048856

GO:0055085

GO:0055093

GO:0060252

GO:0070062

GO:0070327

GO:0071222

GO:0071230

GO:0089718

GO:0097421

GO:0098591

GO:0098713

GO:0150104

GO:1902024

GO:1903577

GO:1903801

GO:1904556

GO:1905460

GO:1905534

GO:1990184

HMNXSV003020116

HMNXSV003028174

HMNXSV003042651

Hs2.325520.2.A1_3p_s_at

ILMN_1720373

M80244_at

PH_hs_0010871

TC16001335.hg

g5926731_3p_a_at

Participates

as a component of

SLC7A5:SLC3A2 [plasma membrane] (Homo sapiens)

Inferred To

Slc7a5 [plasma membrane] (Mus musculus)

Slc7a5 [plasma membrane] (Rattus norvegicus)

slc7a5 [plasma membrane] (Xenopus tropicalis)

Dmel\CG1607 [plasma membrane] (Drosophila melanogaster)

gb [plasma membrane] (Drosophila melanogaster)

SLC7A5 [plasma membrane] (Bos taurus)

SLC7A5 [plasma membrane] (Canis familiaris)

SLC7A5 [plasma membrane] (Sus scrofa)

Homologues of SLC7A5 [plasma membrane] (Drosophila melanogaster)

mnd [plasma membrane] (Drosophila melanogaster)

JhI-21 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_003477.4

Guide to Pharmacology - Targets

896

OpenTargets

ENSG00000103257

ZINC target

Q01650

PRO

Q01650

PDB

7DSK, 7DSQ, 6IRT, 7DSL, 6IRS, 6JMQ, 7DSN

GeneCards

Q01650

HPA

ENSG00000103257-SLC7A5

Ensembl

ENSG00000103257, ENST00000261622, ENSP00000261622

Pharos - Targets

Q01650

Orphanet

24923

ZINC - Predictions - Purchasable

LAT1_HUMAN

HMDB Protein

HMDBP03158