Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Cytochrome c (reduced) [mitochondrial inner membrane]
Stable Identifier
R-HSA-352609
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Ferrous cytochrome c, Cytochrome c-Fe2+
Icon
Locations in the PathwayBrowser for interactor UniProt:Q3SYB3 FX4L6
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c (reduced) [mitochondrial inner membrane] (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
Superoxide reduces cytochrome c (Homo sapiens)
Cytochrome c (reduced) [mitochondrial inner membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c (reduced) [mitochondrial inner membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Cytochrome c (reduced) [mitochondrial inner membrane] (Homo sapiens)
Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)
Cytochrome c (reduced) [mitochondrial inner membrane] (Homo sapiens)
HCCS inserts heme into cytochrome c (Homo sapiens)
Cytochrome c (reduced) [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P99999 CYCS
Gene Names
CYCS, CYC
Chain
initiator methionine:, chain:2-105
Reference Genes
BioGPS Gene:54205 CYCS
COSMIC (genes):CYCS CYCS
CTD Gene:54205 CYCS
dbSNP Gene:54205 CYCS
ENSEMBL:ENSG00000172115 CYCS
ENSEMBL_homo_sapiens_GENE:ENSG00000172115.9 CYCS
HGNC:19986 CYCS
KEGG Gene (Homo sapiens):54205 CYCS
Monarch:54205 CYCS
NCBI Gene:54205 CYCS
OMIM:123970 CYCS
UCSC:P99999 CYCS
Reference Transcript
RefSeq:NM_018947.5 CYCS
Other Identifiers
11722003_at
11722004_s_at
11753803_x_at
17055970
17124130
208905_PM_at
208905_at
229415_PM_at
229415_at
244546_PM_at
244546_at
2904075
3042002
3042003
3042004
3042005
3042006
3042007
3042008
3042009
3042010
3042011
3130960
3130961
3130962
35818_at
54205
70396_at
8138640
83749_at
A_24_P29665
A_24_P573978
A_32_P174083
GE61580
GO:0003824
GO:0005515
GO:0005634
GO:0005739
GO:0005743
GO:0005758
GO:0005829
GO:0006091
GO:0006122
GO:0006123
GO:0006915
GO:0008635
GO:0009055
GO:0012501
GO:0016491
GO:0020037
GO:0022900
GO:0023052
GO:0043226
GO:0043293
GO:0045333
GO:0046872
GO:0070469
GO:0097193
HMNXSV003054060
Hs.157301.0.A1_3p_at
Hs.205711.0.A1_3p_at
ILMN_1730416
M22877_at
PH_hs_0025571
TC07001207.hg
g13529022_3p_at
Participates
as an output of
Superoxide reduces cytochrome c (Homo sapiens)
Electron transfer from ubiquinol to cytochrome c of complex III (Homo sapiens)
HCCS inserts heme into cytochrome c (Homo sapiens)
as an input of
Electron transfer from reduced cytochrome c to molecular oxygen (Homo sapiens)
Other forms of this molecule
AcK-CYCS [mitochondrial intermembrane space]
Cytochrome c (oxidised) [mitochondrial inner membrane]
CYCS [cytosol]
CYCS [mitochondrial intermembrane space]
apo-CYCS [mitochondrial inner membrane]
Inferred To
Cycsl3 [mitochondrial inner membrane]
(Rattus norvegicus)
LOC100519295 [mitochondrial inner membrane]
(Sus scrofa)
Cycsl2 [mitochondrial inner membrane]
(Rattus norvegicus)
LOC100621347 [mitochondrial inner membrane]
(Sus scrofa)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Bos taurus)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Caenorhabditis elegans)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Canis familiaris)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Danio rerio)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Dictyostelium discoideum)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Drosophila melanogaster)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Gallus gallus)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Mus musculus)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Plasmodium falciparum)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Rattus norvegicus)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Schizosaccharomyces pombe)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Sus scrofa)
Cytochrome c (reduced) [mitochondrial inner membrane]
(Xenopus tropicalis)
Homologues of Cytochrome c (reduced) [mitochondrial inner membrane]
(Caenorhabditis elegans)
Homologues of Cytochrome c (reduced) [mitochondrial inner membrane]
(Gallus gallus)
Homologues of Cytochrome c (reduced) [mitochondrial inner membrane]
(Plasmodium falciparum)
Homologues of Cytochrome c (reduced) [mitochondrial inner membrane]
(Rattus norvegicus)
Homologues of Cytochrome c (reduced) [mitochondrial inner membrane]
(Saccharomyces cerevisiae)
Homologues of Cytochrome c (reduced) [mitochondrial inner membrane]
(Sus scrofa)
Homologues of Cytochrome c (reduced) [mitochondrial inner membrane]
(Xenopus tropicalis)
LOC100522842 [mitochondrial inner membrane]
(Sus scrofa)
Modified Residues
Name
heme-bis-L-cysteine (ferroheme c di-L-cysteine(2-) residue) at 15
Coordinate
15
Modification
ferroheme c di-L-cysteine(2-) residue
PsiMod Name
heme-bis-L-cysteine
PsiMod Definition
Cross-link 2.
Name
heme-bis-L-cysteine (ferroheme c di-L-cysteine(2-) residue) at 18
Coordinate
18
Modification
ferroheme c di-L-cysteine(2-) residue
PsiMod Name
heme-bis-L-cysteine
PsiMod Definition
Cross-link 2.
Cross References
RefSeq
NP_061820.1
OpenTargets
ENSG00000172115
HPA
ENSG00000172115-CYCS
GeneCards
P99999
Ensembl
ENSP00000386270
,
ENSG00000172115
,
ENST00000409409
,
ENSP00000307786
,
ENST00000305786
,
ENST00000409764
,
ENSP00000387279
PRO
P99999
Pharos - Targets
P99999
Orphanet
17975
HMDB Protein
HMDBP01762
PDB
6ECJ
,
5EXQ
,
6DUJ
,
5TY3
,
2N3Y
,
3NWV
,
5O10
,
2N9J
,
1J3S
,
3ZOO
,
3ZCF
,
6XNK
,
2N9I
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.718
6
UniProt:O14727 APAF1
4
APAF1 [secretory granule lumen]
(R-HSA-6801271)
APAF1 [extracellular region]
(R-HSA-6806465)
APAF1 [ficolin-1-rich granule lumen]
(R-HSA-6801301)
APAF1 [cytosol]
(R-HSA-50099)
0.688
6
UniProt:P02750 LRG1
4
LRG1 [specific granule lumen]
(R-HSA-6799640)
LRG1 [ficolin-1-rich granule lumen]
(R-HSA-6800888)
LRG1 [extracellular region]
(R-HSA-6799675)
LRG1 [tertiary granule lumen]
(R-HSA-6800891)
0.623
4
UniProt:Q9FKS5 CYC1B
0.558
2
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.556
3
UniProt:Q8N5Z5 KCD17
0.556
3
UniProt:Q8IYG6 LRC56
0.556
3
UniProt:Q3SXR2 CC036
0.556
3
UniProt:Q9BUL5 PHF23
0.556
3
UniProt:Q3SYB3 FX4L6
0.556
3
UniProt:Q6ZMI0-5 PPP1R21
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:A0A0A0MR05 A0A0A0MR05
0.556
3
UniProt:Q6XD76 ASCL4
0.556
3
IntAct:EBI-25835866 CCSB
0.556
3
UniProt:Q9UKG9-2 Q9UKG92
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O00303 EIF3F
1
EIF3F [cytosol]
(R-HSA-72540)
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q9NTN9-3 SEMA4G
0.556
3
UniProt:Q1L5Z9 LONF2
0.556
3
UniProt:O43829 ZBT14
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:Q92797-2 Q927972
0.556
3
UniProt:Q96BR5 COA7
0.556
3
UniProt:Q66K80 RUAS1
0.556
3
UniProt:Q9NSI6-4 BRWD1
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:P06429 VE7
0.553
2
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.536
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text