26S proteosome degrades ODC holoenzyme complex

Stable Identifier
R-HSA-353125
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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26S proteosome degrades ODC holoenzyme complex
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The rapid turnover of ODC is brought about by the 26S proteasome. Proteolytic processing of ODC is highly unusual in that ubiquitination is not required for this degradation. Instead, a non-covalent association with antizyme directs ODC to the proteasome. Antizyme increases the degradation of ODC by enhancing its interaction with the proteasome (Pegg, 2006).
Literature References
PubMed ID Title Journal Year
12660156 Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

Coffino, P, Zhang, M, Pickart, CM

EMBO J 2003
Participants
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Output
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as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
26S proteosome degrades ODC holoenzyme complex (Bos taurus)
26S proteosome degrades ODC holoenzyme complex (Caenorhabditis elegans)
26S proteosome degrades ODC holoenzyme complex (Canis familiaris)
26S proteosome degrades ODC holoenzyme complex (Danio rerio)
26S proteosome degrades ODC holoenzyme complex (Drosophila melanogaster)
26S proteosome degrades ODC holoenzyme complex (Mus musculus)
26S proteosome degrades ODC holoenzyme complex (Rattus norvegicus)
26S proteosome degrades ODC holoenzyme complex (Schizosaccharomyces pombe)
26S proteosome degrades ODC holoenzyme complex (Sus scrofa)
Authored
Gopinathrao, G  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-06-12)
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