26S proteosome degrades ODC holoenzyme complex

Stable Identifier
R-HSA-353125
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The rapid turnover of ODC is brought about by the 26S proteasome. Proteolytic processing of ODC is highly unusual in that ubiquitination is not required for this degradation. Instead, a non-covalent association with antizyme directs ODC to the proteasome. Antizyme increases the degradation of ODC by enhancing its interaction with the proteasome (Pegg, 2006).

Literature References
PubMed ID Title Journal Year
12660156 Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

Zhang, M, Pickart, CM, Coffino, P

EMBO J 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed