Translocation of RIAM to plasma membrane

Stable Identifier
R-HSA-354060
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon the production of activated Rap1A at the plasma membrane, RIAM interacts with Rap1A-GTP with its N-ter RA domain, and with its C-ter PH domain it interacts with PIP2.

Literature References
PubMed ID Title Journal Year
17624957 Platelet integrins and immunoreceptors

Kasirer-Friede, A, Kahn, ML, Shattil, SJ

Immunol Rev 2007
16757337 Rap1 regulation of RIAM and cell adhesion

Lafuente, E, Boussiotis, VA

Methods Enzymol 2006
15469846 RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

Lafuente, EM, van Puijenbroek, AA, Krause, M, Carman, CV, Freeman, GJ, Berezovskaya, A, Constantine, E, Springer, TA, Gertler, FB, Boussiotis, VA

Dev Cell 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created